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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ketendo</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая и экспериментальная тиреоидология</journal-title><trans-title-group xml:lang="en"><trans-title>Clinical and experimental thyroidology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5472</issn><issn pub-type="epub">2310-3787</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/ket10379</article-id><article-id custom-type="elpub" pub-id-type="custom">ketendo-10379</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>De Gustibus</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>De Gustibus</subject></subj-group></article-categories><title-group><article-title>Йодирование соли вдвое снизило риск тиреотоксикоза в Дании</article-title><trans-title-group xml:lang="en"><trans-title>Salt iodization decreased the risk of thyrotoxicosis in Denmark by the halve</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Циммерман</surname><given-names>Майкл Брюс</given-names></name><name name-style="western" xml:lang="en"><surname>Zimmermann</surname><given-names>Michael B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>профессор; председатель</p></bio><bio xml:lang="en"><p>MD, Professor</p><p> </p></bio><email xlink:type="simple">michael.zimmermann@hest.ethz.ch</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p&gt;Швейцарский федеральный технологический институт (ETH); Глобальная сеть по йоду (ГСЙ)&lt;/p&gt;</institution><country>Швейцария</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Swiss Federal Institute of Technology (ETH); Iodine Global Network (IGN)&lt;/p&gt;</institution><country>Switzerland</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>03</day><month>10</month><year>2019</year></pub-date><volume>15</volume><issue>2</issue><fpage>38</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Циммерман М., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Циммерман М.</copyright-holder><copyright-holder xml:lang="en">Zimmermann M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.cet-endojournals.ru/jour/article/view/10379">https://www.cet-endojournals.ru/jour/article/view/10379</self-uri><abstract><p>Статус йодной обеспеченности является ключевым фактором, определяющим частоту нарушений щитовидной железы у взрослых лиц. В обсуждаемом исследовании приводятся данные об изменении частоты возникновения нозологических подтипов явного тиреотоксикоза и гипотиреоза у взрослых лиц в период увеличения потребления йода после введения обязательного йодирования соли в Дании. Авторы тщательно изучили истории болезни всех новых пациентов с явным тиреотоксикозом и гипотиреозом, зарегистрированных в 2014–2016 гг. в открытой когорте населения Северной Ютландии (n = 309 434), где исторически наблюдается умеренный дефицит йода, и сопоставили с показателями заболеваемости в 1997–1998 гг., до начала обязательного йодирования соли в 2001 г. За этот период времени потребление йода с питанием практически удвоилось. При этом уровень заболеваемости подтвержденным явным тиреотоксикозом существенно снизился: с исходного показателя 97,5 случая на 100 000 человек в год в 1997–2000 гг. до 48,8 случая на 100 000 человек в год в 2014–2016 гг. Этот результат был обусловлен значительным снижением заболеваемости многоузловым токсическим зобом, токсической аденомой и болезнью Грейвса во всех возрастных группах как у женщин, так и у мужчин. При этом общая заболеваемость первичным явным гипотиреозом не изменилась.</p></abstract><trans-abstract xml:lang="en"><p>The status of iodine nutrition is a key factor in determining the prevalence of thyroid disorders in adults. The study under discussion provides data on the change in the incidence of nosological subtypes of overt thyrotoxicosis and hypothyroidism in adults during an increase in iodine intake after the introduction of mandatory salt iodization in Denmark. The authors carefully studied the case histories of all new patients with thyrotoxicosis and hypothyroidism registered in 2014–2016 in an open cohort of the population of Northern Jutland (n = 309,434), in which a moderate iodine deficiency has historically been observed and compared with incidence rates in 1997–1998 years before introduction of mandatory salt iodization began 2001. Over this period of time, iodine intake almost doubled. At the same time, the incidence rate of confirmed overt thyrotoxicosis significantly decreased: from the initial rate of 97.5 cases per 100,000 people per year in 1997–2000 to 48.8 cases per 100,000 people per year in 2014–2016. This result was due to a significant decrease in the incidence of multinodular toxic goiter, toxic adenoma and Graves’ disease in all age groups in both women and men. Moreover, the overall incidence of primary overt hypothyroidism has not changed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>йод</kwd><kwd>йодный дефицит</kwd><kwd>йодированная соль</kwd><kwd>тиреотоксикоз</kwd><kwd>гипотиреоз</kwd><kwd>Дания</kwd></kwd-group><kwd-group xml:lang="en"><kwd>iodine</kwd><kwd>iodine deficiency</kwd><kwd>iodized salt</kwd><kwd>thyrotoxicosis</kwd><kwd>hypothyroidism</kwd><kwd>Denmark</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmermann MB, Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol. 2015;3(4):286-295. doi: https://doi.org/10.1016/S2213-8587(14)70225-6.</mixed-citation><mixed-citation xml:lang="en">Zimmermann MB, Boelaert K. Iodine deficiency and thyroid disorders. 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