ketendoКлиническая и экспериментальная тиреоидологияClinical and experimental thyroidology1995-54722310-3787Endocrinology Research Centre10.14341/ket12697ketendo-12697Research ArticleОбзорыReviewsРоль цинка в процессах синтеза и метаболизма гормонов щитовидной железыThe role of zinc in the synthesis and metabolism of thyroid hormoneshttps://orcid.org/0000-0002-8520-8702ТрошинаЕкатерина АнатольевнаSenyushkinaEvgeniya S.

Доктор медицинских наук, член-корр. РАН, профессор; eLibrary SPIN: 8821-8990.

117036, Москва, ул. Дм. Ульянова, д. 11

MD; eLibrary SPIN: 4250-5123.

11 Dm. Ulyanova street, 117036 Moscow

troshina@inbox.ruhttps://orcid.org/0000-0001-7960-8315СенюшкинаЕвгения СемёновнаTroshinaEkaterina А.

Научный сотрудник; eLibrary SPIN: 4250-5123.

117036, Москва, ул. Дм. Ульянова, д. 11

MD, PhD, Professor; eLibrary SPIN: 8821-8990

11 Dm. Ulyanova street, 117036 Moscow

EvgeniyaSenyushkina@yandex.ruНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian Federation2020160320211632530Copyright © Трошина Е.А., Сенюшкина Е.С., 20212021Трошина Е.А., Сенюшкина Е.С.Senyushkina E.S., Troshina E.А.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cet-endojournals.ru/jour/article/view/12697

Примерно одна треть населения мира испытывают дефицит одного или нескольких микронутриентов, причем чаще всего отмечается дефицит йода, железа, цинка, витамина А и фолиевой кислоты. Дефицит одного или нескольких необходимых витаминов и минералов обычно является следствием некачественного питания и/или недостаточного усвоения питательных микроэлементов в результате инфекционно-воспалительных заболеваний. Возможно, дефицит некоторых микроэлементов, в свою очередь, может усугубить дефицит йода и способствовать нарушению функции щитовидной железы. Существуют предположения о взаимосвязи содержания в организме человека йода, селена, железа, цинка c уровнем гормонов щитовидной железы. Цинк является жизненно необходимым микроэлементом для всех живых организмов, участвующим во многих биохимических процессах в клетках, включая дифференцировку и деление клетки, ее рост, клеточный транспорт, транскрипцию, синтез белка, синтез РНК и ДНК, репликацию ДНК. Очень важны его роль как антиоксиданта и участие в функционировании как врожденного (Т-, NK- и NKT-клетки), так и адаптивного иммунитета (противовоспалительные цитокины). В данном обзоре будет рассмотрена роль цинка в процессах синтеза и метаболизма гормонов щитовидной железы.

About one third of the world’s population is deficient in one or more micronutrients, with the most common deficiencies in iodine, iron, zinc, vitamin A and folate. Deficiency of one or more essential vitamins and minerals is usually the result of poor nutrition and / or insufficient absorption of micronutrients as a result of infectious and inflammatory diseases. It is possible that the deficiency of certain trace elements, in turn, can aggravate iodine deficiency and contribute to dysfunction of the thyroid gland. There are assumptions about the relationship between the content of iodine, selenium, iron, zinc in the human body and the level of thyroid hormones. Zinc is a vital trace element for all living organisms, participating in many biochemical processes in cells, including cell differentiation and division, its growth, cell transport, transcription, protein synthesis, RNA and DNA synthesis, and DNA replication. Its role as an antioxidant and participation in the functioning of both innate (T, NK and NKT cells) and adaptive immunity (anti-inflammatory cytokines) are very important. This review will consider the role of zinc in the synthesis and metabolism of thyroid hormones.

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The authors declare that there are no conflicts of interest present.