ketendoКлиническая и экспериментальная тиреоидологияClinical and experimental thyroidology1995-54722310-3787Endocrinology Research Centre10.14341/ket12745ketendo-12745Research ArticleКлинический случайCase ReportРазвитие SARS-CoV-2-атипичного тиреоидита у пациента с тяжелым течением COVID-19Development of SARS-CoV-2 atypical thyroiditis in a patient with severe COVID-19https://orcid.org/0000-0003-2283-8958КолпаковаЕ. А.KolpakovaE. A.

Колпакова Евгения Александровна

117292, ул. Дмитрия Ульянова, д. 11

Evgenia A. Kolpakova, MD

Dmitry Ulyanova street 11, 117292, Moscow

colpakova.ev@mail.ruhttps://orcid.org/0000-0001-8838-8908ВознесенскаяА. А.VoznesenskayaА. А.

Анастасия Александровна Вознесенская

117292, ул. Дмитрия Ульянова, д. 11

Anastasia А. Voznesenskaya, MD

Dmitry Ulyanova street 11, 117292, Moscow

voznastya1997@yandex.ruhttps://orcid.org/0009-0002-1176-1641МетревелиЭ. А.MetreveliE. A.

Этери Автандиловна Метревели

117292, ул. Дмитрия Ульянова, д. 11

Eteri A. Metreveli

Dmitry Ulyanova street 11, 117292, Moscow

sovaa55@mail.ruhttps://orcid.org/0000-0002-1120-8240НиканкинаЛ. В.NikankinaL. V.

Никанкина Лариса Вячеславовна, к.м.н.

117292, ул. Дмитрия Ульянова, д. 11

Larisa V. Nikankina, PhD

Dmitry Ulyanova street 11, 117292, Moscow

larisa.nikankina@yandex.ruhttps://orcid.org/0000-0002-8520-8702ТрошинаЕ. А.TroshinaE. A.

Трошина Екатерина Анатольевна, д.м.н., профессор, член-корреспондент РАН

117292, ул. Дмитрия Ульянова, д. 11

Ekaterina A. Troshina, MD, PhD, professor, corresponding member of the Russian Academy of Sciences

Dmitry Ulyanova street 11, 117292, Moscow

troshina@inbox.ruНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology research centreRussian Federation2022110420231832328Copyright © Колпакова Е.А., Вознесенская А.А., Метревели Э.А., Никанкина Л.В., Трошина Е.А., 20232023Колпакова Е.А., Вознесенская А.А., Метревели Э.А., Никанкина Л.В., Трошина Е.А.Kolpakova E.A., Voznesenskaya А.А., Metreveli E.A., Nikankina L.V., Troshina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cet-endojournals.ru/jour/article/view/12745

Новая коронавирусная инфекция SARS-CoV-2 (COVID-19) вошла в историю как одна из самых смертоносных пандемий человечества. С момента первых сообщений о заражении SARS-CoV-2 появилось множество данных относительно особенностей патогенеза COVID-19 и влияния вируса на различные органы и ткани. Известно, что SARS-CoV-2 может вызывать как легочное, так и системное воспаление, обуславливающее полиорганную дисфункцию. Кроме того, с нчала пандемии продолжают появляться сообщения о взаимосвязи COVID-19 и нарушениями функции щитовидной железы (ЩЖ). В многочисленных исследованиях было продемонстрировано, что ЩЖ и вся ось «гипоталамус-гипофиз-ЩЖ» могут быть значимыми мишенями для патогенного воздействия SARS-CoV-2.Классическими нарушениями функции ЩЖ при инфекционных заболеваниях, описанными также и при COVID-19, считают подострый тиреоидит и вторичный гипотиреоз. Особый интерес вызывает развитие на фоне COVID-19 атипичного тиреоидита-SARS-CoV-2 – состояния, впервые зарегистрированного во время COVID-19, ассоциированного с грозными сердечно-сосудистыми осложнениями и высокой летальностью пациентов с COVID-19, не встречавшемся ранее при других вирусных инфекциях.В данной статье описывается клинический случай развития атипичного тиреоидита- SARS-CoV-2 у пациента с двусторонней вирусной пневмонией в остром периоде COVID-19.

The novel coronavirus infection SARS-CoV-2 (COVID-19) has gone down in history as one of the deadliest pandemics in history. Since the first reports of SARS-CoV-2 infection, a lot of data has appeared regarding the features of the COVID-19 pathogenesis and the effect of the virus on various organs and tissues. It is known that SARS-CoV-2 can cause both pulmonary and systemic inflammation, causing multiple organ dysfunction. In addition, since the beginning of the pandemic, reports of the relationship between COVID-19 and thyroid dysfunction have continued to emerge. Numerous studies have demonstrated that the thyroid gland and the entire hypothalamus-pituitary-thyroid axis can be significant targets for the pathogenic effects of SARS-CoV-2.The classic thyroid dysfunctions in infectious diseases, also described in COVID-19, are subacute thyroiditis and secondary hypothyroidism. Of particular interest is the development of atypical thyroiditis-SARS-CoV-2 against the background of COVID-19, a condition first recorded during COVID-19, associated with formidable cardiovascular complications and high mortality in patients with COVID-19, not previously encountered in other viral infections.This article describes a clinical case of SARS-CoV-2 atypical thyroiditis in a patient with bilateral viral pneumonia in the acute period of COVID-19.

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The authors declare that there are no conflicts of interest present.