ketendoКлиническая и экспериментальная тиреоидологияClinical and experimental thyroidology1995-54722310-3787Endocrinology Research Centre10.14341/ket12805ketendo-12805Research ArticleНАУЧНЫЕ ОБЗОРЫREVIEWSСемейство кальцитонина и этиологическое происхождение С-клеток. Обзор литературыC-cells etiology and calcitonin/cgrp family of peptides. Literature reviewhttps://orcid.org/0000-0001-5592-4794ШевэА.ChevaisA.

Шевэ Анастасия, к.м.н., врач-эндокринолог

117292, Москва, ул. Дм. Ульянова, д. 11

Anastassia Chevais, MD, PhD

11 Dm. Ulyanova street, 117292, Moscow

anastassia93@gmail.comhttps://orcid.org/0000-0003-2122-2297БондаренкоЕ. В.BondarenkoE. V.

Бондаренко Екатерина Владимировна, к.м.н., врач-патоморфолог

Москва

Ekaterina V. Bondarenko, MD, PhD

Moscow

bondarenko.ekatwrina@gmail.comhttps://orcid.org/0000-0002-3220-2438СлащукК. Ю.SlashchukK. Yu.

Слащук Константин Юрьевич, к.м.н., врач-эндокринолог, врач-онколог

Москва

Konstantin Yu. Slashchuk, MD, PhD

Moscow

slashuk911@gmail.comhttps://orcid.org/0000-0002-3951-4338ЭбзееваА. К.EbzeevaA. K.

Эбзеева Аминат Канаматовна, врач-эндокринолог

Москва

Aminat K. Ebzeeva, MD

Moscow

ebzeeva3007@gmail.comhttps://orcid.org/0009-0002-1713-0314ВихиреваК. Д.VikhirevaK. D.

Вихирева Ксения Денисовна, студент

Москва

Ksenya D. Vikhireva, student

Moscow

kseniya.vikhireva@gmail.comhttps://orcid.org/0000-0001-7098-4584БельцевичД. Г.BeltsevichD. G.

Бельцевич Дмитрий Германович, д.м.н., профессор РАН

Москва

Dmitry G. Beltsevich, MD, PhD

Moscow

belts67@gmail.comНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian FederationПервый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation202413122024203413Copyright © Шевэ А., Бондаренко Е.В., Слащук К.Ю., Эбзеева А.К., Вихирева К.Д., Бельцевич Д.Г., 20252025Шевэ А., Бондаренко Е.В., Слащук К.Ю., Эбзеева А.К., Вихирева К.Д., Бельцевич Д.Г.Chevais A., Bondarenko E.V., Slashchuk K.Y., Ebzeeva A.K., Vikhireva K.D., Beltsevich D.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cet-endojournals.ru/jour/article/view/12805

Медуллярный рак щитовидной железы (МРЩЖ) — редкая форма онкологического поражения, происходящая из парафолликулярных, или С-клеток. В настоящее время активно ведутся поиски предикторов течения МРЩЖ и маркеров, способных прогнозировать ответ на лечение. Ключ к пониманию поведения этой опухоли лежит на пересечении эмбриологии и генетики. Несмотря на то, что генетические аспекты развития МРЩЖ детально изучены, вопрос о происхождении С-клеток остается актуальным. На сегодняшний день преобладает теория их эктодермального происхождения, однако в последние годы получены данные об экспрессии у С-клеток факторов, характерных для клеток энтодермального происхождения. Эти данные углубляют понимание их биологической роли и дают основания для дальнейших исследований. С-клетки производят различные белковые пептидные гормоны, включая кальцитонин, а также несколько других. В данной работе акцент сделан на изучении пептидных гормонов семейства кальцитонина (кальцитонин ген-ассоциированный пептид, амилин, адреномедуллин и интермедин), которые играют важную роль во множестве физиологических процессов организма. Некоторые из этих белков и их рецепторов обнаруживаются в злокачественных опухолях и связаны с менее благоприятным прогнозом. В обзорной статье обобщены сведения о происхождении С-клеток и предшественников кальцитонина, а также других структурно схожих с ним пептидов, в контексте МРЩЖ.

Medullary thyroid cancer (MTC) is a rare form of cancer derived from parafollicular or C cells. Currently, there is an active search for predictors of the course of MTC and markers that can predict the treatment response. Understanding the biological characteristics of the tumor requires insights from both embryology and genetics. While the genetic aspects of MTC are relatively well-studied, the embryonic origin of C-cells remains a subject of ongoing investigation. The prevailing hypothesis suggests an ectodermal origin, yet recent studies have identified the expression of markers in C-cells that are typical of cells with endodermal lineage. These data deepen the understanding of their biological role and provide reasons for further research. C-cells produce several essential hormones, including calcitonin, and possess a unique ability to synthesize and secrete other peptide hormones. This article focuses on members of the calcitonin family of hormones — calcitonin gene-related peptide, amylin, adrenomedullin, and intermedin — which regulate critical physiological processes. Some of these hormones and their receptors have been identified in malignant tumors and are associated with poorer prognosis. This review analyzes current findings on the origins of C-cells and calcitonin precursors, along with structurally similar peptides, highlighting their importance in the context of clinical oncology.

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The authors declare that there are no conflicts of interest present.