ketendoКлиническая и экспериментальная тиреоидологияClinical and experimental thyroidology1995-54722310-3787Endocrinology Research Centre10.14341/ket12827ketendo-12827Research ArticleНаучный обзорReviewТиреогастральный синдром: современный взгляд на проблемуThyrogastric syndrome: a modern view of the problemhttps://orcid.org/0000-0002-8520-8702ТрошинаЕ. А.TroshinaE. A.

Трошина Екатерина Анатольевна, д.м.н., профессор, член-корр. 

Москва

Ekaterina A. Troshina, MD, PhD, Professor

Moscow

troshina@inbox.ruhttps://orcid.org/0009-0007-0651-3615БоташеваМ. Х.BotashevaM. H.

Боташева Медина Харуновна

117292, Москва, ул. Дм. Ульянова, д. 11

 

Medina H. Botasheva, MD

11 Dm. Ulyanova street, 117292, Moscow

Botasheva.Medina@mail.ruhttps://orcid.org/0000-0001-8077-9381МазуринаН. В.MazurinaN. V.

Мазурина Наталия Валентиновна, д.м.н. 

Москва

Natalya V. Mazurina, MD, PhD

Moscow

natalyamazurina@mail.ruhttps://orcid.org/0009-0007-4456-7745ЛейтесЮ. Г.LeitesYu. G.

Лейтес Юрий Германович

Москва

Yury G. Leites, MD

Moscow

jleytes@mail.ruГалеевА. С.GaleevA. S.

Галеев Азат Сергеевич

Москва

Azat S. Galeev, MD

Moscow

ellegaleev@yandex.ruНациональный медицинский исследовательский центр эндокринологии имени академика И.И. ДедоваРоссияEndocrinology Research CentreRussian Federation2025040920252112329Copyright © Трошина Е.А., Боташева М.Х., Мазурина Н.В., Лейтес Ю.Г., Галеев А.С., 20252025Трошина Е.А., Боташева М.Х., Мазурина Н.В., Лейтес Ю.Г., Галеев А.С.Troshina E.A., Botasheva M.H., Mazurina N.V., Leites Y.G., Galeev A.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cet-endojournals.ru/jour/article/view/12827

Термин «тиреогастральный синдром» впервые был предложен в начале 1960-х гг. для отражения патогенетической взаимосвязи аутоиммунного тиреоидита и хронического аутоиммунного гастрита. Позднее данная ассоциация рассматривалась в рамках аутоиммунного полигландулярного синдрома 3В типа, где аутоиммунный тиреоидит является обязательным компонентом. Согласно накопленным данным, среди пациентов с верифицированным аутоиммунным тиреоидитом распространенность аутоиммунного гастрита составляет около 13%. Патогенез обоих этих заболеваний определяется взаимодействием генетических, эмбриологических, иммунологических и экологических факторов. Важно отметить, что подобные параллели позволяют лучше понять механизмы аутоиммунных заболеваний и их взаимосвязь. Хронический аутоиммунный гастрит характеризуется частичным или полным исчезновением париетальных клеток желудка, что приводит к нарушению выработки соляной кислоты и внутреннего фактора Кастла. Следствиями этого повреждения могут быть железодефицитная анемия, пернициозная анемия, прогрессирование поражения слизистой оболочки до тяжелой атрофии желудка. Данный обзор посвящен ассоциации двух вышеупомянутых аутоиммунных заболеваний.

The term thyrogastric syndrome was first proposed in the early 1960s to reflect the pathogenetic relationship between autoimmune thyroiditis and chronic autoimmune gastritis. Later, this association was considered in the framework of autoimmune polyglandular syndrome type 3B, where autoimmune thyroiditis is a mandatory component. According to accumulated data, the prevalence of autoimmune gastritis among patients with verified autoimmune thyroiditis is about 13%. The pathogenesis of both of these diseases is determined by the interaction of genetic, embryological, immunological, and environmental factors. It is important to note that such parallels allow for a better understanding of the mechanisms of autoimmune diseases and their relationship. Chronic autoimmune gastritis is characterized by the partial or complete disappearance of the parietal cells of the stomach, which leads to impaired production of hydrochloric acid and internal factor Castl. The consequences of this damage can be iron deficiency anemia, pernicious anemia, and the progression of mucosal damage to severe gastric atrophy. This review focuses on the association of the two aforementioned autoimmune diseases.

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The authors declare that there are no conflicts of interest present.