References

ketendo

Клиническая и экспериментальная тиреоидология

Clinical and experimental thyroidology

1995-54722310-3787

Endocrinology Research Centre

10.14341/ket20117322-29

ketendo-4256

Research Article

Статьи

Articles

Рак околощитовидных желез

Parathyroid carcinoma

Kim

I V

старший научный сотрудник ФГБУ Эндокринологический научный центр

Kusnezov

N S

профессор, доктор мед. наук, заведующий хирургическим отделением ФГБУ Эндокринологический научный центр

Kusnezov

S N

врач хирургического отделения ФГБУ Эндокринологический научный центр

2011

15092011

ТОМ 7, №3 (2011)

2229

2011

Kim I.V., Kusnezov N.S., Kusnezov S.N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.cet-endojournals.ru/jour/article/view/4256

Рак околощитовидных желез (РОЩЖ) – редкоезлокачественное заболевание. У больных РОЩЖ, как правило, отмечается тяжелое течение гиперпаратиреоза с высокими показателями кальция и паратгормона (ПТГ) в крови. Кроме того, у большинства пациентов диагностируются выраженные костные и почечные осложнения гиперпаратиреоза, а у некоторых определяются симптомы местного и отдаленного распространения заболевания. На сегодняшний день нет какого-либо патогномоничного гистопатологического маркера в диагностике РОЩЖ. Окончательный диагноз РОЩЖ основывается на наличии локальной инвазии опухоли или наличии метастазов в лимфатические узлы и отдаленные органы. Малое количество наблюдений, а также трудности диагностики тормозят активное изучение данной патологии. На сегодняшний день в вопросах диагностики и лечения РОЩЖ используется коллективный мировой опыт врачей, занимающихся этой проблемой. Однако многие аспекты этого тяжелого заболевания до сих пор остаются не изученными.

References1

Shane E., Bilezikian J. Parathyroid carcinoma: a review of 62 patients // Endocr. Rev. 1982. N3. P. 218–226.

Shane E., Bilezikian J. Parathyroid carcinoma. In: Williams C.J., Green M.R., Raghaven D., eds. Textbook of uncommon cancer. New York, Wiley & Sons, 1987. P. 763–771.

Cohn K., Silverman M., Corrado J., Sedgewick C. Parathyroid carcinoma: The Lahey Clinic experience // Surgery. 1985 V. 98. P. 1095–1110.

Hakaim A.G., Esselstyn C.B., Jr. Parathyroid carcinoma: 50-year experience at The Cleveland Clinic Foundation. Cleve Clin. J. Med. V. 60. 1993 Р. 331–335.

Sandelin K., Thompson N.W., Bondeson L. Metastatic parathyroid carcinoma: dilemmas in management // Surgery. 1991 V. 110. P. 978–986.

Holmes E., Morton D., Ketcham A. Parathyroid carcinoma: a collective review // Ann. Surg. 1969. V. 169. P. 631–640.

Schantz A., Castleman B. Parathyroid carcinoma: a study of 70 cases // Cancer. 1973. V. 31. P. 600–605.

Wang C., Gaz R. Natural history of parathyroid carcinoma: diagnosis, treatment, and results // Am. J. Surg. 1985. V. 149. P. 522–527.

РАК ОКОЛОЩИТОВИДНЫХ ЖЕЛЕЗ И.В. Ким, Н.С. Кузнецов, С.Н. Кузнецов

Wynne A., Heerden Jv, Carney J., Fitzpatrick L. Parathyroid carcinoma: clinical and pathological features in 43 patients. Medicine. 1992. V. 71. P. 197–205.

Cryns V.L., Rubio M.P., Thor A.D. et al. p53 abnormalities in human parathyroid carcinoma // J. Clin. Endocrinol. Metab. 1994. V. 78. P. 1320–1324.

Shane E. Clinical review 122: Parathyroid carcinoma // J. Clin. Endocrinol. Metab. 2001. V. 86. P. 485–493.

Obara T., Okamoto T., Ito Y. et al. Surgical and medical management of patients with pulmonary metastasis from parathyroid carcinoma // Surgery. 1993. V. 114. P. 1040–1048.

Fujimoto Y., Obara T. How to recognize and treat parathyroid carcinoma // Surg. Clin. North Am. 1987. V. 67. P. 343–357.

Obara T., Fujimoto Y. 1991 Diagnosis and treatment of patients with parathyroid carcinoma: an update and review // Wld. J. Surg. V. 15. P. 738–744.

Obara T., Okamoto T., Kanbe M., Iihara M. Functioning parathyroid carcinoma: clinicopathologic features and rational treatment // Semin. Surg. Oncol. 1997. V. 13. P. 134–141.

Favia G., Lumachi F., Polistina F., D'Amico D.F. Parathyroid carcinoma: sixteen new cases and suggestions for correct management // Wld. J. Surg. 1998. V. 22. P. 1225–1230.

Lee P.K., Jarosek S.L., Virnig B.A. et al. Trends in the incidence and treatment of parathyroid cancer in the United States. Cancer. 2007. V. 109. P. 1736–1741.

Busaidy N.L., Jimenez C., Habra M.A. et al. Parathyroid carcinoma: A 22-year experience. Head Neck. 2004. V. 26. P. 716–726.

Kleinpeter K.P., Lovato J.F., Clark P.B. et al. Is parathyroid carcinoma indeed a lethal disease? // Ann. Surg. Oncol. 2005. N12. P. 260–266.

Hamill J., Maoate K., Beasley S.W. et al. Familial parathyroid carcinoma in a child // J. Paediatr. Child. Health. 2002. V. 38. P. 314–317.

Righi A., Dimosthenous K., Mize J. Mediastinal parathyroid carcinoma with tumor implants in a child: A unique occurrence // Int. J. Surg. Pathol. 2008. V. 16. P. 458–460.

Mashburn M.A., Chonkich G.D., Chase D.R., Petti Jr. G.H. Parathyroid carcinoma: two new cases-diagnosis, therapy, and treatment // Laryngoscope. 1987. V. 97. P. 215–218.

Christmas T.J., Chapple C.R., Noble J.G. et al. Hyperparathyroidism after neck irradiation // Br. J. Surg. 1988. V. 75. P. 873–874.

Ireland J., Fleming S., Levison D. et al. Parathyroid carcinoma associated with chronic renal failure and previous radiotherapy to the neck // J. Clin. Pathol. 1985. V. 38. P. 1114–1118.

Berland Y., Olmer M., Lebreuil G., Grisoli J. Parathyroid carcinoma, adenoma and hyperplasia in a case of chronic renal insufficiency on dialysis. // Clin. Nephrol. 1982. V. 18. P. 154–158.

Haghighi P., Astarita R., Wepsic T., Wolf P. Concurrent primary parathyroid hyperplasia and parathyroid carcinoma // Arch. Pathol. Lab. Med. 1983. V. 107. P. 349–350.

Desch C., Arsensis G., May A., Amatruda J. Parathyroid hyperplasia and carcinoma within one gland // Am. J. Med. 1984. V. 77. P. 131–134.

Murayama T., Kawabe K., Tagami M. A case of parathyroid carcinoma concurred with hyperperplasia: an electron microscopic study // J. Urol. 1977. V. 118. P. 126–127.

Guazzi A., Gabrielli M., Guadagni G. Cytologic features of a functioning parathyroid carcinoma: a case report // Acta Cytol. 1982. V. 26. P. 709–713.

Parham G., Orr J. Hyperparathyroidism secondary to parathyroid carcinoma in pregnancy: a case report // J. Reprod. Med. 1987. V. 32. P. 123–125.

Aldinger K.A., Hickey R.C., Ibanez M.L., Samaan N.A. Parathyroid carcinoma: a clinical study of seven cases of functioning and two cases of nonfunctioning parathyroid cancer // Cancer. 1982. V. 49. P. 388–397.

Kramer W. Association of parathyroid hyperplasia with neoplasia // Am. J. Clin. Pathol. 1970. V. 53. P. 275–283.

Boyle N.H., Ogg C.S., Hartley R.B., Owen W.J. Parathyroid carcinoma secondary to prolonged hyperplasia in chronic renal failure and in coeliac disease // Eur. J. Surg. Oncol. 1999. V. 25. P. 100–103.

Miki H., Sumitomo M., Inoue H. et al. Parathyroid carcinoma in patients with chronic renal failure on maintenance hemodialysis // Surgery. 1996. V. 120. P. 897–901.

Tominaga Y., Numano M., Uchida K. et al. Lung metastasis from parathyroid carcinoma causing recurrent renal hyperparathyroidism in a hemodialysis patient: Report of a case // Surg. Today. 1995. V. 25. P. 984–986.

Frayha R.A., Nassar V.H., Dagher F., Salti I.S. Familial parathyroid carcinoma // Leban. Med. J. 1972. V. 25. P. 299–309.

Dinnen J., Greenwood R., Jone J. et al. Parathyroid carcinoma in familial hyperparathyroidism // J. Clin. Pathol. 1977. V. 30. P. 966–975.

Mallette L., Bilezikian J., Ketcham A., Aurbach G. Parathyroid carcinoma in familiar hyperparathyroidism // Am. J. Med. 1974. V. 57. P. 642–648.

Leborgne J., LeNeel J., Brizelin F., Malvy P. Cancer familiar des parathyroids // J. Chir. 1975. V. 109. P. 315–326.

Streeten E.A., Weinstein L.S., Norton J.A. et al. Studies in a kindred with parathyroid carcinoma // J. Clin. Endocrinol. Metab. 1992. V. 75. P. 362–366.

Kakinuma A., Morimoto I., Nakano Y. et al. Familial primary hyperparathyroidism complicated with Wilms' tumor. Intern Med. 1994. V. 33. P. 123–126.

Wassif W.S., Moniz C.F., Friedman E. et al. Familial isolated hyperparathyroidism: a distinct genetic entity with an increased risk of parathyroid cancer // J. Clin. Endocrinol. Metab. 1993. V. 77. P. 1485–1489.

Szabo J., Heath B., Hill V.M. et al. Hereditary hyperparathyroidism-jaw tumor syndrome: the endocrine tumor gene HRPT2 maps to chromosome 1q21-q31 // Am. J. Hum. Genet. 1995. V. 56. P. 944–950.

Cryns V.L., Thor A., Xu H.J. et al. Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma // N. Engl. J. Med. 1994. V. 330. P. 757–761.

Dotzenrath C., Teh B.T., Farnebo F. et al. Allelic loss of the retinoblastoma tumor suppressor gene: A marker for aggressive parathyroid tumors? // J. Clin. Endocrinol. Metab. 1996. V. 81. P. 3194–3196.

Pearce S.H., Trump D., Wooding C. et al. Loss of heterozygosity studies at the retinoblastoma and breast cancer susceptibility (BRCA2) loci in pituitary, parathyroid, pancreatic and carcinoid tumours // Clin. Endocrinol. (Oxf). 1996. V. 45. P. 195–200.

Subramaniam P., Wilkinson S., Shepherd J.J. Inactivation of retinoblastoma gene in malignant parathyroid growths: A candidate genetic trigger? Aust. N. Z. J. Surg. 1995. V. 65. P. 714–716.

Farnebo F., Auer G., Farnebo L.O. et al. Evaluation of retinoblastoma and Ki-67 immunostaining as diagnostic markers of benign and malignant parathyroid disease // Wld. J. Surg. 1999. V. 23. P. 68–74.

Shattuck T.M., Kim T.S., Costa J. et al. Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma // Clin. Endocrinol. (Oxf). 2003. V. 59. P. 180–189.

Haven C.J., van Puijenbroek M., Tan M.H. et al. Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroid carcinomas // Clin. Endocrinol. (Oxf). 2007. V. 67. P. 370–376.

Vasef M.A., Brynes R.K., Sturm M. et al. Expression of cyclin D1 in parathyroid carcinomas, adenomas, and hyperplasias: A paraffin immunohistochemical study // Mod. Pathol. 1999. N12. P. 412–416.

Woodard G.E., Lin L., Zhang J.H. et al. Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression. Oncogene. 2005. V. 24. P. 1272–1276.

Howell V.M., Haven C.J., Kahnoski K. et al. HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours // J. Med. Genet. 2003. V. 40. P. 657–663.

Carpten J.D., Robbins C.M., Villablanca A. et al. HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome. Nat. Genet. 2002. V. 32. P. 676–680.

Shattuck T.M., Välimäki S., Obara T. et al. Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma // N. Engl. J. Med. 2003. V. 349. P. 1722–1729.

Nakajima K. , Umino K., Azuma Y. et al. Stimulating parathyroid cell proliferation and PTH release with phosphate in organ cultures obtained from patients with primary and secondary hyperparathyroidism for a prolonged period // J. Bone Miner Metab. 2009. V. 27. P. 224–233.

Vel azquez-Fern andez D., Laurell C., Saqui-Salces M. et al. Differential RNA expression profile by cDNA microarray in sporadic primary hyperparathyroidism (pHPT): Primary parathyroid hyperplasia versus adenoma // Wld. J. Surg. 2006. V. 30. P. 705–713.

Forsberg L., Bjorck E., Hashemi J. et al. Distinction in gene expression profiles demonstrated in parathyroid adenomas by high-density oligoarray technology // Eur. J. Endocrinol. 2005. V. 152. P. 459–470.

Haven C.J., Howell V.M., Eilers P.H. et al. Gene expression of parathyroid tumors: Molecular subclassification and identification of the potential malignant phenotype // Cancer. Res. 2004. V. 64. P. 7405–7411.

Abdelgadir Adam M., Untch B.R., Olson J.A. Jr. Parathyroid carcinoma: current understanding and new insights into gene expression and intraoperative parathyroid hormone kinetics // Oncologist. 2010. V. 15(1). P. 61–72.

Kelly M.D., Sheridan B.F., Farnsworth A.E. et al. Parathyroid carcinoma in a mediastinal sixth parathyroid gland // Aust N. Z. J. Surg. 1994. V. 64. P. 446–449.

Kameyama K., Takami H. Double parathyroid carcinoma // Endocr. J. 2003. V. 50. P. 477–479.

Wang C.A., Gaz R.D. Natural history of parathyroid carcinoma. Diagnosis, treatment, and results // Am. J. Surg. 1985. V. 149. P. 522–527.

Sandelin K., Tullgren O., Farnebo L.O. Clinical course of metastatic parathyroid cancer // Wld. J. Surg. 1994. V. 18. P. 594–598.

Sandelin K., Thompson N.W., Bondeson L. Metastatic parathyroid carcinoma: Dilemmas in management // Surgery. 1991. V. 110. P. 978–986.

Cordeiro A.C., Montenegro F.L., Kulcsar M.A. et al. Parathyroid carcinoma // Am. J. Surg. 1998. V. 175. P. 52–55.

Hundahl S.A., Fleming I.D., Fremgen A.M., Menck H.R. Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985–1995: a National Cancer Data Base Report. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1999. V. 86. P. 538–544.

Levin K., Galante M., Clark O. Parathyroid carcinoma versus parathyroid adenoma in patients with profound hypercalcemia // Surgery. 1999. V. 101. P. 647–660.

Silverberg S.J., Shane E., de la Cruz L. et al. Skeletal disease in primary hyperparathyroidism // J. Bone. Miner. Res. 1989. N4. P. 283–291.

Silverberg S., Shane E., Jacobs T. et al. Nephrolithiasis and bone involvement in primary hyperparathyroidism // Am. J. Med. 1990. V. 89. Р. 327–334.

Hara H., Igarashi A., Yano Y. et al. Ultrasonographic features of parathyroid carcinoma // Endocr. J. 2001. V. 48. P. 213–217.

Singhal T., Jacobs M., Mantil J.C. Tc-99m pertechnetate/sestamibi subtraction scan in a case of parathyroid carcinoma // Clin. Nucl. Med. 2008. V. 33. P. 196–197.

Aigner R.M., Fueger G.F., Lax S. A case of parathyroid carcinoma visualized on Tc-99m-sestamibi scintigraphy. Nuklearmedizin. 1997. V. 36. P. 256–258.

Al-Sobhi S., Ashari L.H, Ingemansson S. Detection of metastatic parathyroid carcinoma with Tc-99m sestamibi imaging // Clin. Nucl. Med. 1999. V. 24. P. 21–23.

Clark P., Wooldridge T., Kleinpeter K. et al. Providing optimal preoperative localization for recurrent parathyroid carcinoma: A combined parathyroid scintigraphy and computed tomography approach // Clin. Nucl. Med. 2004. V. 29. P. 681–684.

Agarwal G., Dhingra S., Mishra S.K. et al. Implantation of parathyroid carcinoma along fine needle aspiration track. Langenbecks Arch. Surg. 2006. V. 391. P. 623–626.

Spinelli C., Bonadio A.G., Berti P. et al. Cutaneous spreading of parathyroid carcinoma after fine needle aspiration cytology. J. Endocrinol. Invest. 2000. V. 23. P. 255–257.

Koea J.B., Shaw J.H. Parathyroid cancer: Biology and management. Surg. Oncol. 1999. N8. P. 155–165.

Shortell C.K., Andrus C.H., Phillips C.E. Jr. et al. Carcinoma of the parathyroid gland: A 30-year experience. Surgery. 1991. V. 110. P. 704–708.

Clayman G.L., Gonzalez H.E., El-Naggar A. et al. Parathyroid carcinoma: Evaluation and interdisciplinary management // Cancer. 2004. V. 100. P. 900–905.

Vetto J.T., Brennan M.F., Woodruf J. et al. Parathyroid carcinoma: Diagnosis and clinical history // Surgery. 1993. V. 114. P. 882–892.

Sandelin K., Auer G., Bondeson L. et al. Prognostic factors in parathyroid cancer: A review of 95 cases // Wld. J. Surg. 1992. V. 16. P. 724–731.

Irvin GL 3rd, Solorzano C.C., Carneiro D.M. Quick intraoperative parathyroid hormone assay: Surgical adjunct to allow limited parathyroidectomy, improve success rate, and predict outcome // Wld. J. Surg. 2004. V. 28. P. 1287–1292.

Clary B.M., Garner S.C., Leight G.S. Jr. Intraoperative parathyroid hormone monitoring during parathyroidectomy for secondary hyperparathyroidism. Surgery. 1997;122:1034–1038; discussion 1038–1039.

Sol orzano C.C., Carneiro-Pla D.M. Lew J.I. et al. Intra-operative parathyroid hormone monitoring in patients with parathyroid cancer // Ann. Surg. Oncol. 2007. V. 14. P. 3216–3222.

Howell V.M., Gill A., Clarkson A. et al. Accuracy of combined protein gene product 9.5 and parafibromin markers for immunohistochemical diagnosis of parathyroid carcinoma // J. Clin. Endocrinol. Metab. 2009. V. 94. P. 434–441.

Gill A.J., Clarkson A., Gimm O. et al. Loss of nuclear expression of parafibromin distinguishes parathyroid carcinomas and hyperparathyroidism-jaw tumor (HPT-JT) syndrome-related adenomas from sporadic parathyroid adenomas and hyperplasias // Am. J. Surg. Pathol. 2006. V. 30. P. 1140–1149.

Silverberg S.J., Rubin M.R., Faiman C. et al. Cinacalcet hydrochloride reduces the serum calcium concentration in inoperable parathyroid carcinoma // J. Clin. Endocrinol. Metab. 2007. V. 92. P. 3803–3808.

Collins M.T., Skarulis M.C., Bilezikian J.P. et al. Treatment of hypercalcemia secondary to parathyroid carcinoma with a novel calcimimetic agent // J. Clin. Endocrinol. Metab. 1998. V. 83. P. 1083–1088.

Yip L., Seethala R.R., Nikiforova M.N. et al. Loss of heterozygosity of selected tumor suppressor genes in parathyroid carcinoma // Surgery. 2008. V. 144. P. 949–955.

The authors declare that there are no conflicts of interest present.