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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ketendo</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая и экспериментальная тиреоидология</journal-title><trans-title-group xml:lang="en"><trans-title>Clinical and experimental thyroidology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5472</issn><issn pub-type="epub">2310-3787</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/ket20084416-24</article-id><article-id custom-type="elpub" pub-id-type="custom">ketendo-4288</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>ЗНАЧЕНИЕ ВАРИАБЕЛЬНОСТИ УРОВНЯ ТТГ В КЛИНИЧЕСКОЙ ПРАКТИКЕ</article-title><trans-title-group xml:lang="en"><trans-title>Clinical Significace of Thyrotropin Variability</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Sviridonova</surname><given-names>M A</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Fadeyev</surname><given-names>V V</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib></contrib-group><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2008</year></pub-date><volume>4</volume><issue>4</issue><issue-title>ТОМ 4, №4 (2008)</issue-title><fpage>16</fpage><lpage>24</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Sviridonova M.A., Fadeyev V.V., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Sviridonova M.A., Fadeyev V.V.</copyright-holder><copyright-holder xml:lang="en">Sviridonova M.A., Fadeyev V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.cet-endojournals.ru/jour/article/view/4288">https://www.cet-endojournals.ru/jour/article/view/4288</self-uri><abstract><p>В обзоре обсуждается проблема циркадианной и индивидуальной динамики уровня ТТГ и тиреоидных гормонов и её клиническое значение. Кроме того, в этом контексте обсуждается проблема референсного диапазона для уровня ТТГ.</p></abstract><trans-abstract xml:lang="en"><p>The review of literature discussed the problem of circadian and individual dynamics of TSH and thyroid hormones levels and its importance for clinical practice. Therefore in this connection the problem of TSH reference interval is discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ТТГ</kwd><kwd>тироксин</kwd><kwd>трийодтиронин</kwd><kwd>циркадианный ритм</kwd><kwd>референсный интервал</kwd><kwd>гипотиреоз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>TSH</kwd><kwd>thyroxin</kwd><kwd>triiodtironin</kwd><kwd>circadian rhythms</kwd><kwd>reference interval</kwd><kwd>hypothyroidism</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Фадеев В.В. Нормативы уровня ТТГ: нужны ли изменения? // Клиническая тиреоидология. 2004. № 3. 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