ketendoКлиническая и экспериментальная тиреоидологияClinical and experimental thyroidology1995-54722310-3787Endocrinology Research Centre10.14341/ket20106112-19ketendo-4349Research ArticleСтатьиArticlesНарушения функции щитовидной железы и сердечно-сосудистая системаThyroid function disorders and cardiovascular systemTroshinaE Atroshina@inbox.ruYukinaM Y-OgnevaN A-MazurinaN V-20101503201061ТОМ 6, №1 (2010)1219Copyright © Troshina E.A., Yukina M.Y., Ogneva N.A., Mazurina N.V., 20102010Troshina E.A., Yukina M.Y., Ogneva N.A., Mazurina N.V.Troshina E.A., Yukina M.Y., Ogneva N.A., Mazurina N.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cet-endojournals.ru/jour/article/view/4349

Обзор посвящен влиянию тиреотоксикоза и гипотиреоза на сердечно-сосудистую систему и риск смертности от сердечно-сосудистых заболеваний. Также обсуждаются особенности заместительной терапии препаратами тиреоидных гормонов у пациентов с кардиальной патологией.

The effects of hyperthyroidism and hypothyroidism on cardiovascular system and cardiovascular events mortality risk is reviewed in this article. Also the problems of levothyroxine replacement in hypothyroid patient with cardiovascular diseases are discussed.

гипотиреозтиреотоксикозлевотироксинсердечно-сосудистые заболеванияhypothyroidismhyperthyroidismlevothyroxinecardiovascular diseasesReferencesAghini-Lombardi F., Di Bello V., Talini E. et al. Early textural and functional alterations of left ventricular myocardium in mild hypothyroidism // Eur. J. Endocrinol. 2006. V. 155. P. 3–9.Aghini-Lombardi F., Di Bello V., Talini E. et al. Early textural and functional alterations of left ventricular myocardium in mild hypothyroidism // Eur. J. Endocrinol. 2006. V. 155. P. 3–9.Asvold B.O., Bjoro T., Nilsen T.I. et al. Association between blood pressure and serum TSH concentration within the reference range: a population-based study // J. Clin. Endocrinol. Metab. 2007. V. 92. P. 841–845.Asvold B.O., Bjoro T., Nilsen T.I. et al. Association between blood pressure and serum TSH concentration within the reference range: a population-based study // J. Clin. Endocrinol. Metab. 2007. V. 92. P. 841–845.Åsvold B.O., BjØro T., Nilsen T.I. et al. Thyrotropin Levels and Risk of Fatal Coronary Heart Disease. The HUNT Study // Arch. Intern. Med. 2008. V. 168. P. 855–860.Åsvold B.O., BjØro T., Nilsen T.I. et al. Thyrotropin Levels and Risk of Fatal Coronary Heart Disease. The HUNT Study // Arch. Intern. Med. 2008. V. 168. P. 855–860.Auer J.A., Scheibner P., Mische T. et al. Subclinical hyperthyroidism as a risk factor for atrial fibrillation // Am. Heart. J. 2001. V. 142. P. 838–842.Auer J.A., Scheibner P., Mische T. et al. Subclinical hyperthyroidism as a risk factor for atrial fibrillation // Am. Heart. J. 2001. V. 142. P. 838–842.Bar-Sela S., Ehrenfeld M., Eliakim M. Arterial embolism in thyrotoxicosis with atrial fibrillation // Arch. Intern. Med. 1981. V. 141. P. 1191–1192.Bar-Sela S., Ehrenfeld M., Eliakim M. Arterial embolism in thyrotoxicosis with atrial fibrillation // Arch. Intern. Med. 1981. V. 141. P. 1191–1192.Bauer D.C., Ettinger B., Browner W.S. Thyroid function and serum lipids in older women: a population-based study // Am. J. Med. 1998. V.104. P. 546–551.Bauer D.C., Ettinger B., Browner W.S. Thyroid function and serum lipids in older women: a population-based study // Am. J. Med. 1998. V.104. P. 546–551.Bibbins-Domingo K., Chertow G.M., Fried L.F. et al. Renal function and heart failure risk in older black and white individuals: the Health, Aging, and Body Composition Study // Arch. Intern. Med. 2006. V. 166. P. 1396–1402.Bibbins-Domingo K., Chertow G.M., Fried L.F. et al. Renal function and heart failure risk in older black and white individuals: the Health, Aging, and Body Composition Study // Arch. Intern. Med. 2006. V. 166. P. 1396–1402.Bindels A.J., Westendorp R.G., Frolich M. et al. The prevalence of subclinical hypothyroidism at different total plasma cholesterol levels in middle aged men and women: a need for case-finding? // Clin. Endocrinol. (Oxf.). 1999. V.50. P. 217–220.Bindels A.J., Westendorp R.G., Frolich M. et al. The prevalence of subclinical hypothyroidism at different total plasma cholesterol levels in middle aged men and women: a need for case-finding? // Clin. Endocrinol. (Oxf.). 1999. V.50. P. 217–220.Biondi B., Cooper D.S. The Clinical Significance of Subclinical Thyroid Dysfunction // Endocrin. Rev. 2008. V. 29. P. 76–131.Biondi B., Cooper D.S. The Clinical Significance of Subclinical Thyroid Dysfunction // Endocrin. Rev. 2008. V. 29. P. 76–131.Biondi B. Cardiovascular effects of mild hypothyroidism // Thyroid. 2007. V. 17. P. 625–630.Biondi B. Cardiovascular effects of mild hypothyroidism // Thyroid. 2007. V. 17. P. 625–630.Biondi B., Fazio S., Palmieri E.A. et al. Mortality in elderly patients with subclinical hyperthyroidism // Lancet. 2002. V. 359. P. 799–800.Biondi B., Fazio S., Palmieri E.A. et al. Mortality in elderly patients with subclinical hyperthyroidism // Lancet. 2002. V. 359. P. 799–800.Biondi B., Klein I. Hypothyroidism as a risk factor for cardiovascular disease // Endocrin. 2004. V. 24. P. 1–13.Biondi B., Klein I. Hypothyroidism as a risk factor for cardiovascular disease // Endocrin. 2004. V. 24. P. 1–13.Biondi B., Palmieri E.A., Klain M. et al. Subclinical hyperthyroidism: clinical features and treatment options // Eur. J. Endocrinol. 2005. V. 152. P. 1–9.Biondi B., Palmieri E.A., Klain M. et al. Subclinical hyperthyroidism: clinical features and treatment options // Eur. J. Endocrinol. 2005. V. 152. P. 1–9.Canaris G.J., Manovitz N.R., Mayor G., Ridgway E.C. The Colorado thyroid disease prevalence study // Arch. Intern. Med. 2000. V. 160. P. 526–534.Canaris G.J., Manovitz N.R., Mayor G., Ridgway E.C. The Colorado thyroid disease prevalence study // Arch. Intern. Med. 2000. V. 160. P. 526–534.Cappola A.R. Subclinical thyroid dysfunction and the heart // J. Clin. Endocrinol. Metab. 2007. V. 92. P. 3404–3405.Cappola A.R. Subclinical thyroid dysfunction and the heart // J. Clin. Endocrinol. Metab. 2007. V. 92. P. 3404–3405.Cappola A.R., Fried L.P., Arnold A.M. et al. Thyroid Status, Cardiovascular Risk, and Mortality in Older Adults // JAMA. 2006. V. 295. P. 1033–1041.Cappola A.R., Fried L.P., Arnold A.M. et al. Thyroid Status, Cardiovascular Risk, and Mortality in Older Adults // JAMA. 2006. V. 295. P. 1033–1041.Cappola A.R., Ladenson P.W. Hypothyroidism and atherosclerosis // J. Clin. Endocrinol. Met. 2003. V. 88. P. 2438–2444.Cappola A.R., Ladenson P.W. Hypothyroidism and atherosclerosis // J. Clin. Endocrinol. Met. 2003. V. 88. P. 2438–2444.Clyde P.W., Harari A.E., Getka E.J. et al. Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial // JAMA. 2003. V. 290. P. 2952–2958.Clyde P.W., Harari A.E., Getka E.J. et al. Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial // JAMA. 2003. V. 290. P. 2952–2958.Cooper D.S. Approach to the patient with subclinical hyperthyroidism // J. Clin. Endocrinol. Metab. 2007. V. 92. P. 3–9.Cooper D.S. Approach to the patient with subclinical hyperthyroidism // J. Clin. Endocrinol. Metab. 2007. V. 92. P. 3–9.Cooper D.S., Doherty G.M., Haugen B.R. et al. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer // Thyroid. 2006. V. 16. P. 109–142.Cooper D.S., Doherty G.M., Haugen B.R. et al. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer // Thyroid. 2006. V. 16. P. 109–142.Croteau W., Davey J.C., Galton V.A., St Germain D.L. Cloning of the mammalian type II iodothyronine deiodinase: a selenoprotein differentially expressed and regulated in human and rat brain and other tissues // J. Clin. Invest. 1996. V.98. P. 405–417.Croteau W., Davey J.C., Galton V.A., St Germain D.L. Cloning of the mammalian type II iodothyronine deiodinase: a selenoprotein differentially expressed and regulated in human and rat brain and other tissues // J. Clin. Invest. 1996. V.98. P. 405–417.Escobar-Morreale H.F., Botella-Carretero J.I. Thyroid Hormone Replacement Therapy in Primary Hypothyroidism: A Randomized Trial Comparing L-Thyroxine plus Liothyronine with L-Thyroxine Alone // Ann. Intern. Med. 2005. V. 142. P. 412–424.Escobar-Morreale H.F., Botella-Carretero J.I. Thyroid Hormone Replacement Therapy in Primary Hypothyroidism: A Randomized Trial Comparing L-Thyroxine plus Liothyronine with L-Thyroxine Alone // Ann. Intern. Med. 2005. V. 142. P. 412–424.Fazio S., Palmieri E.A., Lombardi G., Biondi B. Effects of thyroid hormone on the cardiovascular system // Rec. Progr. Horm. Research. 2004. V. 59. P. 31–50.Fazio S., Palmieri E.A., Lombardi G., Biondi B. Effects of thyroid hormone on the cardiovascular system // Rec. Progr. Horm. Research. 2004. V. 59. P. 31–50.Foldes J., Banos C., Winkler G. Subclinical hypothyroidism and arteriosclerosis // Orv. Hetil. 2004. V. 145(31). P. 1601–1607.Foldes J., Banos C., Winkler G. Subclinical hypothyroidism and arteriosclerosis // Orv. Hetil. 2004. V. 145(31). P. 1601–1607.Franklyn J.A., Maisonneuve P., Sheppard M.C. et al. Mortality after the treatment of hyperthyroidism with radioactive iodine // N. Engl. J. Med. 1998. V. 338. P. 712–718.Franklyn J.A., Maisonneuve P., Sheppard M.C. et al. Mortality after the treatment of hyperthyroidism with radioactive iodine // N. Engl. J. Med. 1998. V. 338. P. 712–718.Gilligan D.M., Ellenbogen K.A., Epstein A.E. The management of atrial fibrillation // Am. J. Med. 1996. V. 101. P. 413–421.Gilligan D.M., Ellenbogen K.A., Epstein A.E. The management of atrial fibrillation // Am. J. Med. 1996. V. 101. P. 413–421.Goldman M.B., Maloof F., Monson R.R. et al. Radioactive iodine therapy and breast cancer. A follow-up study of hyperthyroid women // Am. J. Epidemiol. 1988. V. 127. P. 969–980.Goldman M.B., Maloof F., Monson R.R. et al. Radioactive iodine therapy and breast cancer. A follow-up study of hyperthyroid women // Am. J. Epidemiol. 1988. V. 127. P. 969–980.Haentjens P., van Meerhaeghe A. et al. Subclinical thyroid dysfunction and mortality: an estimate of relative and absolute excess allcause mortality based on time-to-event data from cohort studies // Eur. J. Endocrinol. 2008. V. 159(3). P. 329–341.Haentjens P., van Meerhaeghe A. et al. Subclinical thyroid dysfunction and mortality: an estimate of relative and absolute excess allcause mortality based on time-to-event data from cohort studies // Eur. J. Endocrinol. 2008. V. 159(3). P. 329–341.Hak A.E., Pols H.A., Visser T.J. et al. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study // Ann. Intern. Med. 2000. V. 132. P. 270–278.Hak A.E., Pols H.A., Visser T.J. et al. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study // Ann. Intern. Med. 2000. V. 132. P. 270–278.Hall P., Lundell G., Holm L.E. Mortality in patients treated for hyperthyroidism with iodine-131 // Acta Endocrinol.1993. V. 28. P. 230–234.Hall P., Lundell G., Holm L.E. Mortality in patients treated for hyperthyroidism with iodine-131 // Acta Endocrinol.1993. V. 28. P. 230–234.Hueston W.J., Pearson W.S. Subclinical hypothyroidism and the risk of hypercholesterolemia // Ann. Fam. Med. 2004. V. 2. P. 351–355.Hueston W.J., Pearson W.S. Subclinical hypothyroidism and the risk of hypercholesterolemia // Ann. Fam. Med. 2004. V. 2. P. 351–355.Iqbal A., Schirmer H., Lunde P. et al. Thyroid stimulating hormone and left ventricular function // J. Clin. Endocrinol. Met. 2007. V. 92. P. 3504–3510.Iqbal A., Schirmer H., Lunde P. et al. Thyroid stimulating hormone and left ventricular function // J. Clin. Endocrinol. Met. 2007. V. 92. P. 3504–3510.John P., Walsh J.P., Alexandra P. et al. Subclinical Thyroid Dysfunction as a Risk Factor for Cardiovascular Disease // Arch. Intern. Med. 2005. V. 165. P. 2467–2472.John P., Walsh J.P., Alexandra P. et al. Subclinical Thyroid Dysfunction as a Risk Factor for Cardiovascular Disease // Arch. Intern. Med. 2005. V. 165. P. 2467–2472.Kahaly G.J. Cardiovascular and atherogenic aspects of subclinical hypothyroidism // Thyroid. 2000. V. 10. P. 665–679.Kahaly G.J. Cardiovascular and atherogenic aspects of subclinical hypothyroidism // Thyroid. 2000. V. 10. P. 665–679.Kahaly G.J., Dillmann W.H. Thyroid hormone action in the heart // Endocrin. Rev. 2005. V. 26. P. 704–728.Kahaly G.J., Dillmann W.H. Thyroid hormone action in the heart // Endocrin. Rev. 2005. V. 26. P. 704–728.Klein I., Ojamaa K. Thyroid hormone and the cardiovascular system // N. Engl. J. Med. 2001. V. 344. P. 501–509.Klein I., Ojamaa K. Thyroid hormone and the cardiovascular system // N. Engl. J. Med. 2001. V. 344. P. 501–509.Klein I., Danzi S. Thyroid disease and the heart // Circulat. 2007. V. 116. P. 1725–1735.Klein I., Danzi S. Thyroid disease and the heart // Circulat. 2007. V. 116. P. 1725–1735.Krahn A.D., Klein G.J., Kerr C.R. et al. How useful is thyroid function testing in patients with recent-onset atrial fibrillation? The Canadian Registry of Atrial Fibrillation Investigators // Arch. Intern. Med. 1996. V. 156. P. 2221–2224.Krahn A.D., Klein G.J., Kerr C.R. et al. How useful is thyroid function testing in patients with recent-onset atrial fibrillation? The Canadian Registry of Atrial Fibrillation Investigators // Arch. Intern. Med. 1996. V. 156. P. 2221–2224.Mandel S.J., Brent G.A., Larsen P.R. Levothyroxine therapy in patients with thyroid disease // Ann. Intern. Med. 1993. V. 119. P. 492–502.Mandel S.J., Brent G.A., Larsen P.R. Levothyroxine therapy in patients with thyroid disease // Ann. Intern. Med. 1993. V. 119. P. 492–502.Mattace-Raso F.U., van der Cammen T.J., Hofman A. et al. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study // Circulation. 2006. V. 113. P. 657–663.Mattace-Raso F.U., van der Cammen T.J., Hofman A. et al. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study // Circulation. 2006. V. 113. P. 657–663.Mercuro G., Panzuto M.G., Bina A. et al. Cardiac function, physical exercise capacity, and quality of life during long-term thyrotropin-suppressive therapy with levothyroxine: effect of individual dose tailoring // J. Clin. Endocrinol. Metab. 2000. V. 85. P. 159–164.Mercuro G., Panzuto M.G., Bina A. et al. Cardiac function, physical exercise capacity, and quality of life during long-term thyrotropin-suppressive therapy with levothyroxine: effect of individual dose tailoring // J. Clin. Endocrinol. Metab. 2000. V. 85. P. 159–164.Nagasaki T., Inaba M., Kumeda Y. et al. Increased pulse wave velocity in subclinical hypothyroidism // J. Clin. Endocrinol. Metab. 2006. V. 91. P. 154–158.Nagasaki T., Inaba M., Kumeda Y. et al. Increased pulse wave velocity in subclinical hypothyroidism // J. Clin. Endocrinol. Metab. 2006. V. 91. P. 154–158.Nakazawa H.K., Sakurai K., Hamada N. et al. Management of atrial fibrillation in the post-thyrotoxic state // Am. J. Med. 1982. V. 72. P. 903–906.Nakazawa H.K., Sakurai K., Hamada N. et al. Management of atrial fibrillation in the post-thyrotoxic state // Am. J. Med. 1982. V. 72. P. 903–906.Nordyke R.A, Gilbert F.I.Jr., Harada A.S. Graves’ disease. Influence of age on clinical findings // Arch. Intern. Med. 1988. V. 148. P. 626–631.Nordyke R.A, Gilbert F.I.Jr., Harada A.S. Graves’ disease. Influence of age on clinical findings // Arch. Intern. Med. 1988. V. 148. P. 626–631.Parle J.V., Maisonneuve P., Sheppard M.C. et al. Prediction of allcause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study // Lancet. 2001. V. 358. P. 861–865.Parle J.V., Maisonneuve P., Sheppard M.C. et al. Prediction of allcause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study // Lancet. 2001. V. 358. P. 861–865.Petersen P., Hansen J.M. Stroke in thyrotoxicosis with atrial fibrillation // Stroke. 1988. V. 19. P. 15–18.Petersen P., Hansen J.M. Stroke in thyrotoxicosis with atrial fibrillation // Stroke. 1988. V. 19. P. 15–18.Ripoli A., Pingitore A., Favilli B. et al. Does subclinical hypothyroidism affect cardiac pump performance? Evidence from a magnetic resonance imaging study // J. Am. Coll. Cardiol. 2005. V. 45. P. 439–445.Ripoli A., Pingitore A., Favilli B. et al. Does subclinical hypothyroidism affect cardiac pump performance? Evidence from a magnetic resonance imaging study // J. Am. Coll. Cardiol. 2005. V. 45. P. 439–445.Roberts C.G.P., Ladenson P.W. Hypothyroidism // Lancet. 2004. V. 363. P. 793-803.Roberts C.G.P., Ladenson P.W. Hypothyroidism // Lancet. 2004. V. 363. P. 793-803.Rodondi N., Bauer D.C., Cappola A.R. et al. Subclinical Thyroid Dysfunction, Cardiac Function, and the Risk of Heart Failure. The Cardiovascular Health Study // J. Am. Col. Cardiology. 2008. V. 14. P. 1152-1159.Rodondi N., Bauer D.C., Cappola A.R. et al. Subclinical Thyroid Dysfunction, Cardiac Function, and the Risk of Heart Failure. The Cardiovascular Health Study // J. Am. Col. Cardiology. 2008. V. 14. P. 1152-1159.Rodondi N., Newman A.B., Vittinghoff E. et al. Subclinical Hypothyroidism and the Risk of Heart Failure, Other Cardiovascular Events, and Death // Arch. Intern. Med. 2005. V. 165. P. 2460–2466.Rodondi N., Newman A.B., Vittinghoff E. et al. Subclinical Hypothyroidism and the Risk of Heart Failure, Other Cardiovascular Events, and Death // Arch. Intern. Med. 2005. V. 165. P. 2460–2466.Roos A.; Linn-Rasker S.P., van Domburg R.T. et al. The Starting Dose of Levothyroxine in Primary Hypothyroidism Treatment. A Prospective, Randomized, Double-blind Trial. // Arch. Intern. Med. 2005. V. 165. P. 1714–1720.Roos A.; Linn-Rasker S.P., van Domburg R.T. et al. The Starting Dose of Levothyroxine in Primary Hypothyroidism Treatment. A Prospective, Randomized, Double-blind Trial. // Arch. Intern. Med. 2005. V. 165. P. 1714–1720.Sawin C.T., Geller A., Wolf P.A. et al. Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons // N. Engl. J. Med. 1994. V. 331. P. 1249–1252.Sawin C.T., Geller A., Wolf P.A. et al. Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons // N. Engl. J. Med. 1994. V. 331. P. 1249–1252.Sawka A.M., Gerstein H.C., Marriott M.J. et al. Does a combination regimen of thyroxine (T4) and 3,5,3’-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial // J. Clin. Endocrinol. Metab. 2003. V. 88. P. 4551–4555.Sawka A.M., Gerstein H.C., Marriott M.J. et al. Does a combination regimen of thyroxine (T4) and 3,5,3’-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial // J. Clin. Endocrinol. Metab. 2003. V. 88. P. 4551–4555.Sgarbi J.A., Villaca F., Garbeline B. et al. The effects of early antithyroid therapy for endogenous subclinical hyperthyroidism on clinical and heart abnormalities // J. Clin. Endocrinol. Metab. 2003. V. 88. P. 1672–1677.Sgarbi J.A., Villaca F., Garbeline B. et al. The effects of early antithyroid therapy for endogenous subclinical hyperthyroidism on clinical and heart abnormalities // J. Clin. Endocrinol. Metab. 2003. V. 88. P. 1672–1677.Shargorodsky M., Serov S., Gavish D. et al. Long-term thyrotropinsuppressive therapy with levothyroxine impairs small and large artery elasticity and increases left ventricular mass in patients with thyroid carcinoma // Thyroid. 2006. V. 16. P. 381–386.Shargorodsky M., Serov S., Gavish D. et al. Long-term thyrotropinsuppressive therapy with levothyroxine impairs small and large artery elasticity and increases left ventricular mass in patients with thyroid carcinoma // Thyroid. 2006. V. 16. P. 381–386.Siegmund W., Spieker K., Weike A.I. et al. Replacement therapy with levothyroxine plus triiodothyronine (bioavailable molar ratioSiegmund W., Spieker K., Weike A.I. et al. Replacement therapy with levothyroxine plus triiodothyronine (bioavailable molar ratio: 1) is not superior to thyroxine alone to improve well-being and cognitive performance in hypothyroidism // Clin. Endocrinol. (Oxf.). 2004. V. 60. P. 750–757.: 1) is not superior to thyroxine alone to improve well-being and cognitive performance in hypothyroidism // Clin. Endocrinol. (Oxf.). 2004. V. 60. P. 750–757.Singer D.E,. Albers G.W,. Dalen J.E. et al. Antithrombotic Therapy in Atrial Fibrillation: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy // Chest. 2004. V. 126. P. 429S–456S.Singer D.E,. Albers G.W,. Dalen J.E. et al. Antithrombotic Therapy in Atrial Fibrillation: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy // Chest. 2004. V. 126. P. 429S–456S.Singh S., Duggal J., Molnar J. et al. Impact of subclinical thyroid disorders on coronary heart disease, cardiovascular and all-cause mortality: a meta-analysis // Intern. J. Cardiol. 2008. V. 125. P. 41–48.Singh S., Duggal J., Molnar J. et al. Impact of subclinical thyroid disorders on coronary heart disease, cardiovascular and all-cause mortality: a meta-analysis // Intern. J. Cardiol. 2008. V. 125. P. 41–48.Smit J.W., Eustatia-Rutten C.F., Corssmit E.P. et al. Reversible diastolic dysfunction after long-term exogenous subclinical hyperthyroidism: a randomized, placebo-controlled study // J. Clin. Endocrinol. Metab. 2005. V. 90. P. 6041–6047.Smit J.W., Eustatia-Rutten C.F., Corssmit E.P. et al. Reversible diastolic dysfunction after long-term exogenous subclinical hyperthyroidism: a randomized, placebo-controlled study // J. Clin. Endocrinol. Metab. 2005. V. 90. P. 6041–6047.Smith R.N., Taylor S.A., Massey J.C. Controlled clinical trial of combined triiodothyronine and thyroxine in the treatment of hypothyroidism // Br. Med. J.1970. V. 4.P. 145–148.Smith R.N., Taylor S.A., Massey J.C. Controlled clinical trial of combined triiodothyronine and thyroxine in the treatment of hypothyroidism // Br. Med. J.1970. V. 4.P. 145–148.Surks M.I., Ortiz E., Daniels G.H. et al. Subclinical thyroid disease. Scientific review and guidelines for diagnosis and management // J. Am. Med. Assoc. 2004. V. 291. P. 228–238.Surks M.I., Ortiz E., Daniels G.H. et al. Subclinical thyroid disease. Scientific review and guidelines for diagnosis and management // J. Am. Med. Assoc. 2004. V. 291. P. 228–238.Tenerz A., Forberg R., Jansson R. Is a more active attitude warranted in patients with subclinical thyrotoxicosis? // J. Intern. Med. 1999. V. 228. P. 229–233.Tenerz A., Forberg R., Jansson R. Is a more active attitude warranted in patients with subclinical thyrotoxicosis? // J. Intern. Med. 1999. V. 228. P. 229–233.Tunbridge W.M., Evered D.C., Hall R. et al. Lipid profiles and cardiovascular disease in the Whickham area with particular reference to thyroid failure // Clin. Endocrinol. (Oxf.). 1977. V. 7. P. 495–508.Tunbridge W.M., Evered D.C., Hall R. et al. Lipid profiles and cardiovascular disease in the Whickham area with particular reference to thyroid failure // Clin. Endocrinol. (Oxf.). 1977. V. 7. P. 495–508.Vanderpump M.P., Tunbridge W.M., French J.M. et al. The development of ischemic heart disease in relation to autoimmune thyroid disease in a 20-year follow-up study of an English community // Thyroid. 1996. V. 6. P. 155–160.Vanderpump M.P., Tunbridge W.M., French J.M. et al. The development of ischemic heart disease in relation to autoimmune thyroid disease in a 20-year follow-up study of an English community // Thyroid. 1996. V. 6. P. 155–160.Völzke H., Schwahn C., Wallaschofski H. et al. Review: the association of thyroid dysfunction with all-cause and circulatory mortality: is there a causal relationship? // J. Clin. Endocrinol. Metab. 2007. V. 92. P. 2421–2429.Völzke H., Schwahn C., Wallaschofski H. et al. Review: the association of thyroid dysfunction with all-cause and circulatory mortality: is there a causal relationship? // J. Clin. Endocrinol. Metab. 2007. V. 92. P. 2421–2429.Walsh J.P., Shiels L., Lim E.M. et al. Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism // J. Clin. Endocrinol. Metab. 2003. V. 88. P. 4543–4550.Walsh J.P., Shiels L., Lim E.M. et al. Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism // J. Clin. Endocrinol. Metab. 2003. V. 88. P. 4543–4550.Yazici M., Gorgulu S., Sertbas Y. et al. Effects of thyroxin therapy on cardiac function in patients with subclinical hypothyroidism: index of myocardial performance in the evaluation of left ventricular function // Intern. J. Cardiol. 2004. V. 95. P. 135–143.Yazici M., Gorgulu S., Sertbas Y. et al. Effects of thyroxin therapy on cardiac function in patients with subclinical hypothyroidism: index of myocardial performance in the evaluation of left ventricular function // Intern. J. Cardiol. 2004. V. 95. P. 135–143.Zile M.R., Brutsaert D.L. New concepts in diastolic dysfunction and diastolic heart failure. Part II: causal mechanisms and treatment // Circulat. 2002. V. 105. P. 1503–1508.Zile M.R., Brutsaert D.L. New concepts in diastolic dysfunction and diastolic heart failure. Part II: causal mechanisms and treatment // Circulat. 2002. V. 105. P. 1503–1508.Zindrou D., Taylor K.M., Bagger J.P. Excess coronary artery bypass graft mortality among women with hypothyroidism // Ann. Thorac. Surg. 2002. V. 74. P. 2121–2125.Zindrou D., Taylor K.M., Bagger J.P. Excess coronary artery bypass graft mortality among women with hypothyroidism // Ann. Thorac. Surg. 2002. V. 74. P. 2121–2125.

The authors declare that there are no conflicts of interest present.