ketendoКлиническая и экспериментальная тиреоидологияClinical and experimental thyroidology1995-54722310-3787Endocrinology Research Centre10.14341/ket20106139-45ketendo-4353Research ArticleСтатьиArticlesЦиркадианная и индивидуальная вариабельность уровня ТТГ и тиреоидных гормонов у лиц без нарушений функции щитовидной железыCircadian and individual variability of TSH and thyroid hormones in subjects with euthyroidismSviridonovaM A-FadeyevV V-IlyinA V-20101503201061ТОМ 6, №1 (2010)3945Copyright © Sviridonova M.A., Fadeyev V.V., Ilyin A.V., 20102010Sviridonova M.A., Fadeyev V.V., Ilyin A.V.Sviridonova M.A., Fadeyev V.V., Ilyin A.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cet-endojournals.ru/jour/article/view/4353

В исследование были включены 27 лиц без диагностированных нарушений функции ЩЖ в возрасте 18-60 лет. Изучение циркадианной и индивидуальной вариабельности уровней ТТГ, св.Т4, св.Т3 у лиц с эутиреозом проводилось в 8.00–9.00 и 14.00–16.00 в течение одного дня, а также в 8.00–9.00 через 4–6 нед. Медиана уровня ТТГ в утренние часы составила 2,28 мЕд/л, в дневные – 1,6 мЕд/л. Диапазон суточных колебаний в процентном отношении достигал 58% (Ме = 21,45%). В соответствии с действующим референсным интервалом 0,4–4,0 мЕд/л у всех лиц, включенных в исследование, и в утренние, и в дневные часы определялся эутиреоз (ТТГ ≤4 мЕд/л), в соответствии с предлагаемым референсным интервалом 0,4–2,5 мЕд/л у 12 лиц (44,4%) в утренние и у 4 лиц (14,8%) в дневные часы определялся гипотиреоз. Уровни ТТГ через 4–6 нед отличались от исходных на -42,8–7,71%. Статистически и клинически значимой вариабельности уровня св.Т4 выявлено не было. Вариабельность уровня св.Т3 оказалась статистически значимой и коррелировала с колебаниями уровня ТТГ.

To ivestigate circadian and individual variability of TSH, fТ4, fТ3 in subjects without evident thyroid dysfunction. 27 persons at the age of 18–60 years have been included. Measurements of serum TSH, fT4, fT3 were performed at 8.00–9.00 and 14.00–16.00 during the day and at 8.00–9.00 in 4–6 weeks. The median of TSH concentrations in the morning was 2.28 mU/l, at the daytime – 1.6 mU/l (р < 0.05). The amplitude of TSH circadian variability reached 58% (Me = 21.45%). According to the current TSH reference ranges (0.4–4.0 mU/l) all participants had an euthyroidism in the morning and at the daytime. According to the proposed TSH reference ranges (0.4–2.5 mU/l) 12 participants (44.4%) in the morning and 4 participants (14.8%) at the daytime have been classified as having a hypothyroidism. TSH levels in 4–6 weeks differed from initial on -42.8–7.71%. Statistically and clinically significant variability of fT4 has not been found. Variability of fТ3 has appeared statistically significant and correlation with TSH changes.

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The authors declare that there are no conflicts of interest present.