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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ketendo</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая и экспериментальная тиреоидология</journal-title><trans-title-group xml:lang="en"><trans-title>Clinical and experimental thyroidology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5472</issn><issn pub-type="epub">2310-3787</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/ket2009524-16</article-id><article-id custom-type="elpub" pub-id-type="custom">ketendo-4367</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Гипотиреоз, субклинический гипотиреоз, высоконормальный уровень ТТГ</article-title><trans-title-group xml:lang="en"><trans-title>Hypothyroidism, Subclinical Hypothyroidism, High-normal TSH-level</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Podzolkov</surname><given-names>A V</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Fadeyev</surname><given-names>V V</given-names></name></name-alternatives><email xlink:type="simple">walfad@mail.ru</email></contrib></contrib-group><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>15</day><month>06</month><year>2009</year></pub-date><volume>5</volume><issue>2</issue><issue-title>ТОМ 5, №2 (2009)</issue-title><fpage>4</fpage><lpage>16</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Podzolkov A.V., Fadeyev V.V., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Podzolkov A.V., Fadeyev V.V.</copyright-holder><copyright-holder xml:lang="en">Podzolkov A.V., Fadeyev V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.cet-endojournals.ru/jour/article/view/4367">https://www.cet-endojournals.ru/jour/article/view/4367</self-uri><abstract><p>В обзоре обсуждаются проблемы диагностики и лечения субклинического гипотиреоза, а также референсного интервала для уровня ТТГ. Обсуждается вопрос о целесообразности изменения референсного интервала и целевого диапазона для уровня ТТГ на фоне заместительной терапии гипотиреоза.</p></abstract><trans-abstract xml:lang="en"><p>The review of literature discusses the problems of diagnostics and therapy of subclinical hypothyroidism and reference ranges for thyroid stimulating hormone. Expediency of change of reference range for TSH and target TSHlevel on L-thyroxine replacement therapy in patients with hypothyroidism is also discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гипотиреоз</kwd><kwd>субклинический гипотиреоз</kwd><kwd>тиреотропный гормон</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypothyroidism</kwd><kwd>subclinical hypothyroidism</kwd><kwd>thyroid stimulatein hormone</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis // JAMA. 2002. V. 288. N 16. P. 2015–2022.</mixed-citation><mixed-citation xml:lang="en">Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis // JAMA. 2002. V. 288. N 16. 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