ketendoКлиническая и экспериментальная тиреоидологияClinical and experimental thyroidology1995-54722310-3787Endocrinology Research Centre10.14341/ket20095230-33ketendo-4370Research ArticleСтатьиArticlesВозможные последствия сужения референсного интервала для уровня ТТГPossible Consequences of Changing of the TSH Reference RangesSviridonovaM A-IlyinA V-KolesnikovaG S-FadeyevV Vwalfad@mail.ru20091506200952ТОМ 5, №2 (2009)3033Copyright © Sviridonova M.A., Ilyin A.V., Kolesnikova G.S., Fadeyev V.V., 20092009Sviridonova M.A., Ilyin A.V., Kolesnikova G.S., Fadeyev V.V.Sviridonova M.A., Ilyin A.V., Kolesnikova G.S., Fadeyev V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cet-endojournals.ru/jour/article/view/4370

Проведено ретроспективное исследование уровней ТТГ и св.Т4 пациентов (n = 1014), госпитализированных в ФГУ ЭНЦ в связи с нетиреоидной патологией. В соответствии с принятыми в настоящее время нормативами для ТТГ (0.4–4.0 мЕд/л) распространенность гипотиреоза в этой выборке составила 10% (n = 104). Для оценки возможных после! дствий сужения референсного интервала для уровня ТТГ была рассчитана распространенность его значений более 2,5 мЕд/л, которая составила 24% (n = 250). Таким образом, в случае снижения верхнего норматива уровня ТТГ число лиц с гипотиреозом может увеличиться в 2,5 раза.

We retrospectively analyzed the results of measurements of serum TSH and free T4 concentrations performed in1014 patients hospitalised in Federal Endocrinological Research Center without known thyroid disorders. According to the present TSH reference ranges (0.4–4.0 mU/l), prevalence of a hypothyroidism in the sample was10% (n = 104). For an estimation of possible consequences of lowering TSH reference interval prevalence of TSH> 2.5 mU/l has been calculated as 24% (n = 250). Тhus, in case of reduction of upper limits for TSH the quantity of persons with a hypothyroidism can increase in 2,5 times.

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The authors declare that there are no conflicts of interest present.