ketendoКлиническая и экспериментальная тиреоидологияClinical and experimental thyroidology1995-54722310-3787Endocrinology Research Centre10.14341/ket20062222-26ketendo-4400Research ArticleСтатьиArticlesРОЛЬ МОЛЕКУЛЯРНЫХ МАРКЕРОВ В ДИФФЕРЕНЦИАЛЬНОЙ ДИАГНОСТИКЕ ФОЛЛИКУЛЯРНЫХ ОПУХОЛЕЙ ЩИТОВИДНОЙ ЖЕЛЕЗЫMolecular Markers in Differential Diagnostics of Follicular Neoplasms of the ThyroidTroshinaE-MasurinaN-AbesadseI-YushkovP-GarbusovP-20061506200622ТОМ 2, №2 (2006)2226Copyright © Troshina E., Masurina N., Abesadse I., Yushkov P., Garbusov P., 20062006Troshina E., Masurina N., Abesadse I., Yushkov P., Garbusov P.Troshina E., Masurina N., Abesadse I., Yushkov P., Garbusov P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cet-endojournals.ru/jour/article/view/4400

Тонкоигольная аспирационная биопсия (ТАБ) является единственным методом морфологической диагностики на дооперационном этапе исследования, хотя этот метод имеет ряд ограничений. В 10-30% случаев результаты цитологического исследования расцениваются как “неопределенные” или подозрительные на злокачественные. К ним относят фолликулярные опухоли щитовидной железы, так как на основании цитологического исследования не представляется возможным отличить фолликулярную аденому от фолликулярного рака. Достижения молекулярной медицины позволяют с помощью молекулярных маркеров проводить дополнительное исследование как цитологического, так и операционного материала. Наиболее полезными молекулярными маркерами в клинической практике оказались тиреоидная пероксидаза (ТПО), теломераза и галектин-3. Проведение ТАБ с последующим иммуноцитохимическим исследованием в ткани щитовидной железы позволит усовершенствовать дифференциальный диагноз между доброкачественными и злокачественными образованиями щитовидной железы.

Ultrasound-guided fine-needle aspiration biopsy (FNAB) is a basic method of morphological diagnostics at the preoperative examination, although it has some limitations. In 10-30 % of the cases, cytological examination results defined as indefinite or suspicious to malignant nodules, including follicular neoplasm, as according to the results of a cytological examination it does not appear to be possible to make the difference between follicular attendance the molecular markers adenomas and follicular cancer. Molecular medicine progress let us put an additional examination in a cytological, or surgical aspirates with the molecular markers. The most effective molecular markers in the clinical practice are thyroid peroxidases (TPO), telomerase and galectin-3. The application FNAB with the following immunocytochemistry examination in the thyroid tissue let us improve a differential diagnostics between benign and malignant nodules of the thyroid.

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The authors declare that there are no conflicts of interest present.