ketendoКлиническая и экспериментальная тиреоидологияClinical and experimental thyroidology1995-54722310-3787Endocrinology Research Centre10.14341/ket20073312-24ketendo-4431Research ArticleСтатьиArticlesМЕДИКО-СОЦИАЛЬНЫЕ АСПЕКТЫ ЗАМЕСТИТЕЛЬНОЙ ТЕРАПИИ ГИПОТИРЕОЗА: ФАКТОРЫ, ВЛИЯЮЩИЕ НА КАЧЕСТВО КОМПЕНСАЦИИSocial and Medical Aspects of Replacement Thyroxine Therapy: Factors of Compensation QualityMorgunovaT

Кафедра эндокринологии

-ManuilovaYu

Кафедра эндокринологии

-FadeyevV

Кафедра эндокринологии

-20071509200733ТОМ 3, №3 (2007)1224Copyright © Morgunova T., Manuilova Y., Fadeyev V., 20072007Morgunova T., Manuilova Y., Fadeyev V.Morgunova T., Manuilova Y., Fadeyev V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cet-endojournals.ru/jour/article/view/4431

Обзор литературы посвящен медико-социальным аспектам компенсации гипотиреоза. В нем обсуждаются современные принципы заместительной терапии, частота и причины декомпенсации, а также методы улучшения комплаентности пациентов. Также затрагиваются вопросы качества жизни и самочувствия пациентов на заместительной терапии препаратами тиреоидных гормонов.

The review devotes to medicosocial aspects of the compensation in patients with primary hypothyroidism. Actual principals of the hormone replacement therapy, reasons for chronic decompensation and methods of compliance increasing are discussed. Also the authors pay attention to the questions of quality of life and well-being in patient's groups with compensated hypothyroidism.

ReferencesНовик А.А., Ионова Т.И. Исследование качества жизни в медицине: Учеб. пособие; Под ред. Ю.Л. Шевченко. М.: ГЭОТАР-МЕД, 2004.Новик А.А., Ионова Т.И. Исследование качества жизни в медицине: Учеб. пособие; Под ред. Ю.Л. Шевченко. М.: ГЭОТАР-МЕД, 2004.Петунина Н.А. Использование препаратов гормонов щитовидной железы в клинической практике// Клиническая тиреоидология. 2003. № 2.Петунина Н.А. Использование препаратов гормонов щитовидной железы в клинической практике// Клиническая тиреоидология. 2003. № 2.Фадеев В.В. Современные концепции диагностики и лечения гипотиреоза у взрослых // Проблемы эндокринологии. 2004. Т. 50, № 2.Фадеев В.В. Современные концепции диагностики и лечения гипотиреоза у взрослых // Проблемы эндокринологии. 2004. Т. 50, № 2.Anderson R.M., Fitzgerald J.T., Oh M.S. The relationship of diabetes-related attitudes and patients’ self-reported adherence // Diabetes Educ. 1993. V. 19. P. 287—292.Anderson R.M., Fitzgerald J.T., Oh M.S. The relationship of diabetes-related attitudes and patients’ self-reported adherence // Diabetes Educ. 1993. V. 19. P. 287—292.Arafah B. Increased need for thyroxine in women with hypothyroidism during estrogen therapy // The New England Journal of Medicine. 2000. V. 344(23). P. 1743—1749.Arafah B. Increased need for thyroxine in women with hypothyroidism during estrogen therapy // The New England Journal of Medicine. 2000. V. 344(23). P. 1743—1749.Bianchi G.P., Zaccheroni V., Solaroli E. et al. Health-related quality of life in patients with thyroid disorders // Qual Life Res. 2004. V. 13(1). P. 45—54.Bianchi G.P., Zaccheroni V., Solaroli E. et al. Health-related quality of life in patients with thyroid disorders // Qual Life Res. 2004. V. 13(1). P. 45—54.Biondi B., Palmieri E.A., Lombardi G., Fazio S. Effects of subclinical thyroid dysfunction on the heart // Ann. Intern. Med. 2002. V. 137. P. 904—914.Biondi B., Palmieri E.A., Lombardi G., Fazio S. Effects of subclinical thyroid dysfunction on the heart // Ann. Intern. Med. 2002. V. 137. P. 904—914.Braverman L.E., Ingbar S.H., Sterling K. Conversion of thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects // The Journal of clinical investigation. 1970. V. 49, N 5. P. 855—864.Braverman L.E., Ingbar S.H., Sterling K. Conversion of thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects // The Journal of clinical investigation. 1970. V. 49, N 5. P. 855—864.Bunevidus R., Kaanavièius G., alinkevièius R., Prange A.J. Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism // The New England Journal of Medicine. 1999. V. 340, N 6. P. 424—429.Bunevidus R., Kaanavièius G., alinkevièius R., Prange A.J. Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism // The New England Journal of Medicine. 1999. V. 340, N 6. P. 424—429.Burmeister L.A., Ganguli M., Dodge H.H. et al. Hypothyroidism and cognition: preliminary evidence for a specific defect in memory // Thyroid. 2001. V. 11 P. 1177—1185.Burmeister L.A., Ganguli M., Dodge H.H. et al. Hypothyroidism and cognition: preliminary evidence for a specific defect in memory // Thyroid. 2001. V. 11 P. 1177—1185.Burnett J.R., Cooke R., Crooke M.J., Feek C.M. A study of L-thyroxine replacement // N. Z. Med. J. 1992. V. 105(930). P. 105—106.Burnett J.R., Cooke R., Crooke M.J., Feek C.M. A study of L-thyroxine replacement // N. Z. Med. J. 1992. V. 105(930). P. 105—106.Canaris G., Manowitz N., Mayor G., Ridgway E. Do traditional symptoms of hypothyroidism correlate with biochemical disease? // J. of Gen. Intern. Med. 1997. V. 12. P. 544—550.Canaris G., Manowitz N., Mayor G., Ridgway E. Do traditional symptoms of hypothyroidism correlate with biochemical disease? // J. of Gen. Intern. Med. 1997. V. 12. P. 544—550.Canaris G.J., Manowitz N.R., Mayor G., Ridgway E.C. The Colorado thyroid disease prevalence study // Arch. Internal Med. 2000. V. 160. P. 526—534.Canaris G.J., Manowitz N.R., Mayor G., Ridgway E.C. The Colorado thyroid disease prevalence study // Arch. Internal Med. 2000. V. 160. P. 526—534.Carr D., McLeod D.T., Parry G., Thornes H.M. Fine adjustment of thyroxine replacement dosage: comparison of the thyrotropin releasing hormone test using a sensitive thyrotropin assay with measurement of free thyroid hormones and clinical assessment // Clin Endocrinol. 1988. V. 28. P. 325—333.Carr D., McLeod D.T., Parry G., Thornes H.M. Fine adjustment of thyroxine replacement dosage: comparison of the thyrotropin releasing hormone test using a sensitive thyrotropin assay with measurement of free thyroid hormones and clinical assessment // Clin Endocrinol. 1988. V. 28. P. 325—333.Cassio A., Cacciari E., Cicognani A. et al. Treatment for congenital hypothyroidism: thyroxine alone or thyroxine plus triiodothyronine? // Pediatrics. 2003. V. 111, N. 5. P. 1055—1060.Cassio A., Cacciari E., Cicognani A. et al. Treatment for congenital hypothyroidism: thyroxine alone or thyroxine plus triiodothyronine? // Pediatrics. 2003. V. 111, N. 5. P. 1055—1060.Clyde P.W., Harari A. E., Getka E. J., Shakir K.M. Combined Levothyroxine Plus Liothyronine Compared With Levothyroxine Alone in Primary Hypothyroidism // JAMA. 2003. V. 290, N. 22. P. 2952—2958.Clyde P.W., Harari A. E., Getka E. J., Shakir K.M. Combined Levothyroxine Plus Liothyronine Compared With Levothyroxine Alone in Primary Hypothyroidism // JAMA. 2003. V. 290, N. 22. P. 2952—2958.Cuthbertson D.J., Flynn R.W., Jung R.T., Leese G.P. Optimisation of thyroid hormone replacement using an automated thyroid register // Int. J. Clin. Pract. 2006. V. 60(6). P. 660—664.Cuthbertson D.J., Flynn R.W., Jung R.T., Leese G.P. Optimisation of thyroid hormone replacement using an automated thyroid register // Int. J. Clin. Pract. 2006. V. 60(6). P. 660—664.Delamater A.M. Improving patient adherence // Clin. Diabetes. 2006. V. 24(2). P. 71—77.Delamater A.M. Improving patient adherence // Clin. Diabetes. 2006. V. 24(2). P. 71—77.Delamater A.M., Jacobson A.M., Anderson B.J. et al. Psychosocial therapies in diabetes: report of the Psychosocial Therapies Working Group // Diabetes Care. 2001. V. 24. P. 1286—1282.Delamater A.M., Jacobson A.M., Anderson B.J. et al. Psychosocial therapies in diabetes: report of the Psychosocial Therapies Working Group // Diabetes Care. 2001. V. 24. P. 1286—1282.Demers Laurence M., Spencer Carole A. NACB: Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease. National Academy of Clinical Biochemistry, 2002. www.nacb.orgDemers Laurence M., Spencer Carole A. NACB: Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease. National Academy of Clinical Biochemistry, 2002. www.nacb.orgDemet M., Ozmen B., Deveci A. et al. Depression and anxiety in hypothyroidism // West Indian Med. J. 2003. V. 52(3). P. 233—237Demet M., Ozmen B., Deveci A. et al. Depression and anxiety in hypothyroidism // West Indian Med. J. 2003. V. 52(3). P. 233—237Diez J.J. Hypothyroidism in patients older than 55 years: an analysis of the etiology and assessment of the effectiveness of therapy // J.Gerontol a boil sci med sci. 2002. V. 57(5) / P. 315—320.Diez J.J. Hypothyroidism in patients older than 55 years: an analysis of the etiology and assessment of the effectiveness of therapy // J.Gerontol a boil sci med sci. 2002. V. 57(5) / P. 315—320.Evered D., Young E., Ormston B. et al. Treatment of hypothyroidism: a reappraisal of thyroxine therapy // BMJ. 1973. V. 3, N 5872. P. 131—134.Evered D., Young E., Ormston B. et al. Treatment of hypothyroidism: a reappraisal of thyroxine therapy // BMJ. 1973. V. 3, N 5872. P. 131—134.Flynn R.W., Morris A.D., Jung R.T. et al. Does an automated thyroid register improve the clinical management of hypothyroid patients? An observational study // Clin Endocrinol. 2005. V. 63. P. 116—118.Flynn R.W., Morris A.D., Jung R.T. et al. Does an automated thyroid register improve the clinical management of hypothyroid patients? An observational study // Clin Endocrinol. 2005. V. 63. P. 116—118.Frey H., Johannesen O., Kapelrud H., Sand T. Appropriate replacement dose of thyroxine in primary hypothyroidism // Acta Med. Scand. 1987. V. 222. P. 163—167.Frey H., Johannesen O., Kapelrud H., Sand T. Appropriate replacement dose of thyroxine in primary hypothyroidism // Acta Med. Scand. 1987. V. 222. P. 163—167.Gold M.S., Pottash A.L., Extein I. Hypothyroidism and depression. Evidence from complete thyroid function evaluation // JAMA. 1981. V. 15, 245(19). P. 1919—1922.Gold M.S., Pottash A.L., Extein I. Hypothyroidism and depression. Evidence from complete thyroid function evaluation // JAMA. 1981. V. 15, 245(19). P. 1919—1922.Gordon M.B., Gordon M.C. Variations in adequate levothyroxine replacement therapy in patients with different causes of hypothyroidism // Endocrine Practice. 1999. V. 5(5). P. 233—238.Gordon M.B., Gordon M.C. Variations in adequate levothyroxine replacement therapy in patients with different causes of hypothyroidism // Endocrine Practice. 1999. V. 5(5). P. 233—238.Gulseren S., Gulseren L., Hekimsoy Z. et al. Depression, anxiety, health-related quality of life, and disability in patients with overt and subclinical thyroid dysfunction // Arch. Med. Res. 2006. V. 37, N 1. P. 133—139.Gulseren S., Gulseren L., Hekimsoy Z. et al. Depression, anxiety, health-related quality of life, and disability in patients with overt and subclinical thyroid dysfunction // Arch. Med. Res. 2006. V. 37, N 1. P. 133—139.Haggerty J.J.Jr., Prange A.J. Borderline hypothyroidism an depression // Ann. Rev. of Med. 1995. V. 46. P.37—46.Haggerty J.J.Jr., Prange A.J. Borderline hypothyroidism an depression // Ann. Rev. of Med. 1995. V. 46. P.37—46.Hanna F., Lazarus H., Scanlon M. Controversial aspects of thyroid disease // Brit. Med. J. 1999.V. 319. P. 894—898.Hanna F., Lazarus H., Scanlon M. Controversial aspects of thyroid disease // Brit. Med. J. 1999.V. 319. P. 894—898.Havrankova J., Lahaie R. Levothyroxine binding by sucralfate // Ann. of Intern. Med. 1992. V. 117. P. 445—446.Havrankova J., Lahaie R. Levothyroxine binding by sucralfate // Ann. of Intern. Med. 1992. V. 117. P. 445—446.Helfand M., Crapo L. Monitoring therapy in patients taking levothyroxine // Ann. of Intern. Med. 1990. V. 113, N 6. P. 450—454.Helfand M., Crapo L. Monitoring therapy in patients taking levothyroxine // Ann. of Intern. Med. 1990. V. 113, N 6. P. 450—454.Howland R.H. Thyroid dysfunction in refractory depression: implication for pathophysiology and treatment // J. Clin. Psychiatry. 1993. V. 54 (2). P.47—54.Howland R.H. Thyroid dysfunction in refractory depression: implication for pathophysiology and treatment // J. Clin. Psychiatry. 1993. V. 54 (2). P.47—54.Hueston W. Treatment of hypothyroidism // American family physician. 2001. V. 64. P. 1717—1724.Hueston W. Treatment of hypothyroidism // American family physician. 2001. V. 64. P. 1717—1724.Joffe R.T., Levitt A.J. Major depression and subclinical (grade 2) hypothyroidism // Psychoneuroendocrinology. 1992. V. 17(2—3). P. 215—221.Joffe R.T., Levitt A.J. Major depression and subclinical (grade 2) hypothyroidism // Psychoneuroendocrinology. 1992. V. 17(2—3). P. 215—221.Ladenson P. Psychological wellbeing in patients // Clin.l Endocrinol. 2002. V. 57. P. 575—576.Ladenson P. Psychological wellbeing in patients // Clin.l Endocrinol. 2002. V. 57. P. 575—576.Lee Vivian W.Y., Leung Pak Yug. Glycemic control and medication compliance in diabetic patients in a pharmacist-managed clinic in Hong Kong // Am. J. Health—Syst. Pharm. 2003. V. 60, N 24. P. 2593—2596.Lee Vivian W.Y., Leung Pak Yug. Glycemic control and medication compliance in diabetic patients in a pharmacist-managed clinic in Hong Kong // Am. J. Health—Syst. Pharm. 2003. V. 60, N 24. P. 2593—2596.Leese G.P., Jung R.T., Scott A. et al. Long-term follow-up of treated hyperthyroid and hypothyroid patients // Health bull (Edinburg). 1993. V. 51(3). P. 177—183.Leese G.P., Jung R.T., Scott A. et al. Long-term follow-up of treated hyperthyroid and hypothyroid patients // Health bull (Edinburg). 1993. V. 51(3). P. 177—183.Levitt A., Silverberg J. T4 plus T3 treatment for hypothyroidism: a double-blind comparison with usual T4: 74th Annual Meeting of the American Thyroid Association, October 10-13. Los Angeles, California, 2002.Levitt A., Silverberg J. T4 plus T3 treatment for hypothyroidism: a double-blind comparison with usual T4: 74th Annual Meeting of the American Thyroid Association, October 10-13. Los Angeles, California, 2002.Liewendahl K., Helenius T., Lamberg B.A. et al. Free thyroxine, free triiodothyronine, and thyrotropin concentrations in hypothyroid and thyroid carcinoma patients receiving thyroxine therapy // Acta Endocrinol. 1987. V. 116(3). P. 418—424.Liewendahl K., Helenius T., Lamberg B.A. et al. Free thyroxine, free triiodothyronine, and thyrotropin concentrations in hypothyroid and thyroid carcinoma patients receiving thyroxine therapy // Acta Endocrinol. 1987. V. 116(3). P. 418—424.Lindsay R.S., Toft A.D. Hypothyroidism // Lancet. 1997. V. 349, N 9049. P. 413—417.Lindsay R.S., Toft A.D. Hypothyroidism // Lancet. 1997. V. 349, N 9049. P. 413—417.Mandell S.J., Brent G.A., Larsen P.R. Levothyroxine Therapy in Patients with Thyroid Disease // Ann. of Intern. Med. 1993. V. 119(6). P. 492—502.Mandell S.J., Brent G.A., Larsen P.R. Levothyroxine Therapy in Patients with Thyroid Disease // Ann. of Intern. Med. 1993. V. 119(6). P. 492—502.McDermott M.T., Haugen B.R., Lezotte D.C. Management practices among primary care physicians and thyroid specialists in the care of hypothyroid patients // Thyroid. 2001. V. 11(8). P. 757—764.McDermott M.T., Haugen B.R., Lezotte D.C. Management practices among primary care physicians and thyroid specialists in the care of hypothyroid patients // Thyroid. 2001. V. 11(8). P. 757—764.McMillan C., Bradley C., Woodcock A., Razvi S., Weaver J. Design of new questionnaires to measure quality of life and treatment satisfaction in hypothyroidism // Thyroid. 2004. V. 14(11).P. 916—925.McMillan C., Bradley C., Woodcock A., Razvi S., Weaver J. Design of new questionnaires to measure quality of life and treatment satisfaction in hypothyroidism // Thyroid. 2004. V. 14(11).P. 916—925.Muir T., Zegarac M. Societal costs of exposure to toxic substances: economic and health costs of four case studies that are candidates for environmental causation // Environmental health perspectives. 2001. V. 109 (S. 6).Muir T., Zegarac M. Societal costs of exposure to toxic substances: economic and health costs of four case studies that are candidates for environmental causation // Environmental health perspectives. 2001. V. 109 (S. 6).Munoz-Cruzado Poce M.J., Carcia Navas A.J., Moreno Gomez M.L. et al. Prevalence of thyroid disorders in patients diagnosed with depression // Attention primaria. 2000. V. 26(3). P. 176—179.Munoz-Cruzado Poce M.J., Carcia Navas A.J., Moreno Gomez M.L. et al. Prevalence of thyroid disorders in patients diagnosed with depression // Attention primaria. 2000. V. 26(3). P. 176—179.Oppenheimer J., Braverman L., Toft A. et al. A therapeutic controversy. Thyroid hormone treatment: when and what? // J. Clin. Endocrinol. Metab. 1995. V. 80, N 10. P. 2873—2876.Oppenheimer J., Braverman L., Toft A. et al. A therapeutic controversy. Thyroid hormone treatment: when and what? // J. Clin. Endocrinol. Metab. 1995. V. 80, N 10. P. 2873—2876.Osterweil D., Syndulko K., Cohen S.N. et al. Cognitive function in non-demented older adults with hypothyroidism // J. Am. Geriatr. Soc. 1992. V. 40. P. 325—335.Osterweil D., Syndulko K., Cohen S.N. et al. Cognitive function in non-demented older adults with hypothyroidism // J. Am. Geriatr. Soc. 1992. V. 40. P. 325—335.Parle J.V., Franklyn J.A., Cross K.W. et al. Prevalence and follow-up of abnormal thyrotrophin (TSH) concentration in the elderly in the United Kingdom // Clin. Endocrinol. (Oxford). 1991. V. 34(1). P. 77—83.Parle J.V., Franklyn J.A., Cross K.W. et al. Prevalence and follow-up of abnormal thyrotrophin (TSH) concentration in the elderly in the United Kingdom // Clin. Endocrinol. (Oxford). 1991. V. 34(1). P. 77—83.Pies R.W. The diagnosis and treatment of subclinical hypothyroidism states in depression patients // Gen. Hosp. Psychiatry. 1997. V. 19(5). P. 344—354.Pies R.W. The diagnosis and treatment of subclinical hypothyroidism states in depression patients // Gen. Hosp. Psychiatry. 1997. V. 19(5). P. 344—354.Pollock M.A., Sturrock A., Marshall K. et al. Thyroxine treatment in patients with symptoms of hypothyroidism but thyroid function tests within reference range: randomized double blind placebo controlled crossover trial // BMJ. 2001. V. 323. P. 891—895.Pollock M.A., Sturrock A., Marshall K. et al. Thyroxine treatment in patients with symptoms of hypothyroidism but thyroid function tests within reference range: randomized double blind placebo controlled crossover trial // BMJ. 2001. V. 323. P. 891—895.Rack S.K., Makela E.H. Hypothyroidism and depression: a therapeutic challenge // The annals of pharmacotherapy. 2000. V. 34, N 1. P. 1142—1145.Rack S.K., Makela E.H. Hypothyroidism and depression: a therapeutic challenge // The annals of pharmacotherapy. 2000. V. 34, N 1. P. 1142—1145.Razvi S., McMillant C., Weaver J. Instruments used in measuring symptoms, health status and quality of life in hypothyroidism: a systematic qualitative review // Clin. Endocrinol. 2005. V. 63. P. 617—624.Razvi S., McMillant C., Weaver J. Instruments used in measuring symptoms, health status and quality of life in hypothyroidism: a systematic qualitative review // Clin. Endocrinol. 2005. V. 63. P. 617—624.Romijn J.A., Smith J.W.A., Lamberts S.W.J. Intrinsic imperfections of endocrine replacement therapy// Eur. J. of Endocrinol. 2003. V. 149. P. 91—97.Romijn J.A., Smith J.W.A., Lamberts S.W.J. Intrinsic imperfections of endocrine replacement therapy// Eur. J. of Endocrinol. 2003. V. 149. P. 91—97.Roti E., Minelli R., Gardini E., Braverman L.E. The use and misuse of thyroid hormone // Endocrine reviews. 1993. V. 14, N 4. P. 401—423.Roti E., Minelli R., Gardini E., Braverman L.E. The use and misuse of thyroid hormone // Endocrine reviews. 1993. V. 14, N 4. P. 401—423.Saravanan P., Chau F., Roberts N. et al. Psychological well-being in patients on ‘adequate’ doses of L-thyroxine // Clin. Endocrinol. 2002. V. 57, N 5. P. 577—585.Saravanan P., Chau F., Roberts N. et al. Psychological well-being in patients on ‘adequate’ doses of L-thyroxine // Clin. Endocrinol. 2002. V. 57, N 5. P. 577—585.Saravanan P., Simmons D.J., Greenwood R. et al. Partial Substitution of Thyroxine (T4) with Tri-Iodothyronine in Patients on T4 Replacement Therapy: Results of a Large Community-Based Randomized Controlled Trial // J. Clin. Endocrinol. Metab. 2005. V. 90. P. 805—812.Saravanan P., Simmons D.J., Greenwood R. et al. Partial Substitution of Thyroxine (T4) with Tri-Iodothyronine in Patients on T4 Replacement Therapy: Results of a Large Community-Based Randomized Controlled Trial // J. Clin. Endocrinol. Metab. 2005. V. 90. P. 805—812.Sawin C., Geller A., Hershman J., Castell W., Bacharach P. The aging thyroid. The use of thyroid hormone in older persons // JAMA. 1989. V. 12, 226(18). P. 2653—2655.Sawin C., Geller A., Hershman J., Castell W., Bacharach P. The aging thyroid. The use of thyroid hormone in older persons // JAMA. 1989. V. 12, 226(18). P. 2653—2655.Sawka A. M., Gerstein H. C., Marriott M. J. et al. Does a Combination Regimen of Thyroxine (T4) and 3, 5, 3’- Triiodothyronine Improve Depressive Symptoms Better Than T4 Alone in Patients with Hypothyroidism? Results of a Double-Blind, Randomized, Controlled Trial // J. Clin. Endocrinol. and Metab. 2003. V. 88, N. 10. P. 4551—4555.Sawka A. M., Gerstein H. C., Marriott M. J. et al. Does a Combination Regimen of Thyroxine (T4) and 3, 5, 3’- Triiodothyronine Improve Depressive Symptoms Better Than T4 Alone in Patients with Hypothyroidism? Results of a Double-Blind, Randomized, Controlled Trial // J. Clin. Endocrinol. and Metab. 2003. V. 88, N. 10. P. 4551—4555.Sevinc A., Savli H. Hypothyroidism masquerading as depression: the role of noncompliance // J. Natl. Med. Assoc. 2004. 96 (3). P. 379—382.Sevinc A., Savli H. Hypothyroidism masquerading as depression: the role of noncompliance // J. Natl. Med. Assoc. 2004. 96 (3). P. 379—382.Seshadri M., Samuel B., Kanagasabapathy A., Cherian A. Clinical scoring system for hypothyroidism: is it useful? // J. Gen. Intern. Med. 1989. V. 4(6). P. 490—492.Seshadri M., Samuel B., Kanagasabapathy A., Cherian A. Clinical scoring system for hypothyroidism: is it useful? // J. Gen. Intern. Med. 1989. V. 4(6). P. 490—492.Singh N., Singh P., Hershman J. Effect of calcium carbonate on the absorption of levothyroxine // JAMA. 2000. V. 283(21). P. 2822—2825.Singh N., Singh P., Hershman J. Effect of calcium carbonate on the absorption of levothyroxine // JAMA. 2000. V. 283(21). P. 2822—2825.Schifferdecker E., Balz F., Jungmann E., Schoffling K. Compliance problems in therapy with levothyroxine // Med. Klin (Munich). 1990. V. 85(8). P. 477—480.Schifferdecker E., Balz F., Jungmann E., Schoffling K. Compliance problems in therapy with levothyroxine // Med. Klin (Munich). 1990. V. 85(8). P. 477—480.Stock J.M., Surks M.I., Oppenheimer J.H. Replacement dosage of L-thyroxine in hypothyroidism. A re-evaluation // N. Engl. J. Med. 1974. V. 290. P. 529—533.Stock J.M., Surks M.I., Oppenheimer J.H. Replacement dosage of L-thyroxine in hypothyroidism. A re-evaluation // N. Engl. J. Med. 1974. V. 290. P. 529—533.Surks M.I., Schadlow A.R., Stock J.M., Oppenheimer J.H. Determination of iodothyronine absorption and conversion of L-thyroxine (T4 ) to L-triiodothyronine (T3 ) using turnover rate techniques // The Journal of clinical investigation. 1973. V. 52, N4. P. 805—811.Surks M.I., Schadlow A.R., Stock J.M., Oppenheimer J.H. Determination of iodothyronine absorption and conversion of L-thyroxine (T4 ) to L-triiodothyronine (T3 ) using turnover rate techniques // The Journal of clinical investigation. 1973. V. 52, N4. P. 805—811.Toft A. Thyroxine therapy // The New England journal of medicine. 1994. V. 331(3). P. 174—180.Toft A. Thyroxine therapy // The New England journal of medicine. 1994. V. 331(3). P. 174—180.Toft A.D. Thyroid hormone replacement — one hormone or two? // N. Engl. J. Med. 1999. V. 340. P. 469—470.Toft A.D. Thyroid hormone replacement — one hormone or two? // N. Engl. J. Med. 1999. V. 340. P. 469—470.Vanderpump M., Tunbridge W., French J. et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham survey // Clin. Endocrinol. 1995. V. 43(1). P. 55—68.Vanderpump M., Tunbridge W., French J. et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham survey // Clin. Endocrinol. 1995. V. 43(1). P. 55—68.Wekking E., Appelhof B., Fliers E., Schene A. et al. Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism // Eur. journal of Endocrinol. 2005. V. 153(6). P. 747—753.Wekking E., Appelhof B., Fliers E., Schene A. et al. Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism // Eur. journal of Endocrinol. 2005. V. 153(6). P. 747—753.Walsh J.P., Shiels L., Lim E.M. et al. Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism // J. Clin. Endocrinol. Metab. 2003. V. 88. P. 4543—4550.Walsh J.P., Shiels L., Lim E.M. et al. Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism // J. Clin. Endocrinol. Metab. 2003. V. 88. P. 4543—4550.Walsh J.P., Ward L.C., Burke V., Bhagat C.I. et al. Small changes in thyroxine dosage do not produce measurable changes in hypothyroid symptoms, well-being or quality of life: results of a double blind, randomized clinical trial // J. Clin. Endocrinol. Metab. 2006. V. 91. P. 2624—2630.Walsh J.P., Ward L.C., Burke V., Bhagat C.I. et al. Small changes in thyroxine dosage do not produce measurable changes in hypothyroid symptoms, well-being or quality of life: results of a double blind, randomized clinical trial // J. Clin. Endocrinol. Metab. 2006. V. 91. P. 2624—2630.Watt T., Groenvold M., Rasmussen A.K., Bonnema S.J. et al. Quality of life in patients with benign thyroid disorders. A review // Eur. J. Endocrinol. 2006. V. 154, N.4. P. 501—510.Watt T., Groenvold M., Rasmussen A.K., Bonnema S.J. et al. Quality of life in patients with benign thyroid disorders. A review // Eur. J. Endocrinol. 2006. V. 154, N.4. P. 501—510.Weetman A.P. // Hypothyroidism: screening and subclinical disease // Brit. Med. J. 1997. V. 314. P. 1175—1178.Weetman A.P. // Hypothyroidism: screening and subclinical disease // Brit. Med. J. 1997. V. 314. P. 1175—1178.Wiersinga W.M. Adult hypothyroidism in Thyroid Disease Manager, 2004. www.thyroidmanager.orgWiersinga W.M. Adult hypothyroidism in Thyroid Disease Manager, 2004. www.thyroidmanager.orgZulewski H., Muller B., Exer P. et al. Estimation of tissue hypothyroidism by a new clinical score: evaluation of patients with various grades of hypothyroidism and controls // J. of Clin. Endocrinol. and Metab. 1997. V. 82, N 3. P. 771—776.Zulewski H., Muller B., Exer P. et al. Estimation of tissue hypothyroidism by a new clinical score: evaluation of patients with various grades of hypothyroidism and controls // J. of Clin. Endocrinol. and Metab. 1997. V. 82, N 3. P. 771—776.

The authors declare that there are no conflicts of interest present.