ketendoКлиническая и экспериментальная тиреоидологияClinical and experimental thyroidology1995-54722310-3787Endocrinology Research Centre10.14341/ket20128425-26ketendo-4453Research ArticleСтатьиArticlesФеномен макротиротропинемии в современной клинической практикеMakro-thyrotropinemia in clinical practicSorokinM Yu

врач-эндокринолог диабетологического центра, МБУЗ г. Новосибирска ГКБ № 1

biokvant@bk.ru20121512201284ТОМ 8, №4 (2012)2526Copyright © Sorokin M.Y., 20122012Sorokin M.Y.Sorokin M.Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cet-endojournals.ru/jour/article/view/4453

В последние годы в литературе активно обсуждается феномен макропролактинемии в ряду причин гипердиагностики гиперпролактинемии, и определение мономерного биологически активного пролактина широко внедрилось в клиническую практику [1, 2, 3, 4]. Уже не вызывает сомнений, что высокомолекулярные изоформы пролактина не проявляют биологической активности, а следовательно, даже значимые их концентрации не приводят к развитию гиперпролактинемического гипогонадизма. Выявление умеренной гиперпролактинемии без определения фракции макропролактина может привести к ошибочной постановке диагноза и назначению необоснованного лечения. В практике лабораторной диагностики наибольшее распространение для исследования уровня макропролактина получил тест преципитации с полиэтиленгликолем (ПЭГ-тест).

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The authors declare that there are no conflicts of interest present.