References

ketendo

Клиническая и экспериментальная тиреоидология

Clinical and experimental thyroidology

1995-54722310-3787

Endocrinology Research Centre

10.14341/ket20095147-52

ketendo-4489

Research Article

Статьи

Articles

Связь полиморфизма C1858T гена PTPN22 с аутоиммунным тиреоидитом с исходом в гипотиреоз в популяции Новосибирска

Association of PTPN22 Haplotypes with Hashimotos Thyroiditis in Population of Novosibirsk

Nikitin

Rymar

rootnii@online.nsk.su

Maksimov

Simonova

Zankina

Mustafina

Sherbakova

Chernova

Voevoda

2009

15032009

ТОМ 5, №1 (2009)

4752

2009

Nikitin Y., Rymar O., Maksimov V., Simonova G., Zankina M., Mustafina S., Sherbakova L., Chernova N., Voevoda M.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.cet-endojournals.ru/jour/article/view/4489

Полиморфизм 1858 C/T (Arg620Тrp) гена PTPN22 ассоциируется с повышенным риском развития аутоиммунных заболеваний. Цель исследования. Анализ ассоциаций полиморфизма C1858T гена PTPN22 с аутоиммунными заболеваниями ЩЖ в популяции Новосибирска.Материал и методы. Обследовано 358 человек: 108 пациентов (средний возраст – 41,67 ± 1,22 года) С ДТЗ, длительностью заболевания 4,04 ± 0,53 года; 107 больных (средний возраст – 44,11 ± 1,18 года) с АИТ с исходом в гипотиреоз, длительностью заболевания 5,00 ± 0,48 года. Группа сравнения – 143 человека (53,0 ± 0,5 года) без функциональной и структурной патологии ЩЖ.Результаты. В группе больных АИТ с исходом в гипотиреоз выявлена ассоциация с полиморфным маркером C1858T гена PTPN22 : гомозиготный генотип TT встречается чаще, чем в группе здоровых: 5,6 против 0,7%; χ2 = 6,94; р = 0,008. Носительство T -aллеля достоверно чаще, чем в группе здоровых: 24,3 против 12,9%; χ2 = 10,8; р = 0,001 Носительство T -аллеля ассоциировано с повышенным риском развития АИТ с исходом в гипотиреоз у взрослых новосибирской популяции; ОШ = 2,16;95% ДИ 1,36–3,44. В группе больных с АИТ у женщин носительство T -аллеля встречается достоверно чаще, чем в группе здо-ровых: 24,7 против 12,1%; χ2 = 7,62; р = 0,006. Носительство T -аллеля ассоциировано с повышенным риском АИТ у женщин: ОШ = 2,39; 95% ДИ 1,27–4,89. У больных ДТЗ, как у мужчин, так и у женщин, не обнаружено разницы в частоте генотипов и аллелей полиморфизма C1858T гена PTPN22 по сравнению с контрольной группой.

The single nucleotide polymorphism (SNP) C1858T within the PTPN22 gene was recently associated with autoimmune thyroid disease (AITD). The purpose of this study was to examine the joint association of this polymorphism with the AITD. Materials and methods: In this association study 358 subjects were genotyped for the C1858T polymorphism PTPN22 gene. The study population included 215 patients with both autoimmune thyroid diseases (AITD): 108 Novosibirsk patients with Graves' disease (GD) and 107 Hashimotos thyroiditis (HT), and 143 healthy controls. Results. No differences in genotype frequencies were observed between GD and controls for the C1858T polymorphism PTPN22 gene in population of Novosibirsk. The PTPN22 1858 T-allele frequency was strongly increased in patients with HT 24,3% versus controls 12.9%; χ2 = 10.8, (р = 0.001, OR = 2.16, 95% CI 1.36–3.44). The T-allele frequency was 24.7% in women with HT and 12,1% in the control group; χ2 = 7.62, р = 0.006. The T-allele were associated with the increased risk for HT in women (odds ratio OR = 2.39 95% CI 1.27-4.89). Conclusion: The PTPN22 gene is a joint susceptibility locus for HT.

диффузный токсический зобаутоиммунный тиреоидитгены кандидатыполиморфизм C1858T гена PTPN22популяция Новосибирска

autoimmune thyroid diseasePTPN22 gene polymorphismsHashimoto's thyroiditisGraves' disease

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The authors declare that there are no conflicts of interest present.