ketendoКлиническая и экспериментальная тиреоидологияClinical and experimental thyroidology1995-54722310-3787Endocrinology Research Centre10.14341/ket20062121-32ketendo-4514Research ArticleСтатьиArticlesЗОБОГЕННЫЕ ВЕЩЕСТВА И ФАКТОРЫEnvironmental Goitrogens and Goitrogenic FactorsAbramovaN

Кафедра эндокринологии

-FadeyevV

Кафедра эндокринологии

-GerasimovG-MelnichenkoG

Кафедра эндокринологии

-20061503200621ТОМ 2, №1 (2006)2132Copyright © Abramova N., Fadeyev V., Gerasimov G., Melnichenko G., 20062006Abramova N., Fadeyev V., Gerasimov G., Melnichenko G.Abramova N., Fadeyev V., Gerasimov G., Melnichenko G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cet-endojournals.ru/jour/article/view/4514

В представленном обзоре литературы обсуждаются зобогенные факторы окружающей среды, механизмы их зобогенного эффекта и их потенциальный удельный вес в патогенезе эндемического зоба.

This review of literature is dedicated to goitrogenic environmental factors, their goitrogenic mechanisms and their potential role in pathogenesis of endemic goiter.

ReferencesAbdel Gadir W.S., Adam S. Development of goiter and enterohepatonephropathy in Nubian goats fed with pearl millet (Pennisetum Thyphoides) // Viterinary J. 1999. V. 157. P. 178-185.Abdel Gadir W.S., Adam S. Development of goiter and enterohepatonephropathy in Nubian goats fed with pearl millet (Pennisetum Thyphoides) // Viterinary J. 1999. V. 157. P. 178-185.Ahlborg U.G., Brouwer A., Fingerhut M.A. et al. Impact of polychlorinated dibezo-p-dioxins, dibenzofurans and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept // Eur J Pharmacol. 1992. V. 228. P. 179-199.Ahlborg U.G., Brouwer A., Fingerhut M.A. et al. Impact of polychlorinated dibezo-p-dioxins, dibenzofurans and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept // Eur J Pharmacol. 1992. V. 228. P. 179-199.Aufmkolk M., Ingbar J.C., Amir S.M. et al. Inhibition by certain plant exstracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes // Endocrinology. 1984. V. 115. P. 527-534.Aufmkolk M., Ingbar J.C., Amir S.M. et al. Inhibition by certain plant exstracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes // Endocrinology. 1984. V. 115. P. 527-534.Barceloux D.G. Cobalt // J Toxicol Clin Toxicol. 1999. V. 37. P. 201-206.Barceloux D.G. Cobalt // J Toxicol Clin Toxicol. 1999. V. 37. P. 201-206.Barregard L., Lindstedt G., Schutz A. et al. Endocrine function in mercury exposed chloralkali workers // Occup Environ Med. 1994. V. 51. P. 536-540.Barregard L., Lindstedt G., Schutz A. et al. Endocrine function in mercury exposed chloralkali workers // Occup Environ Med. 1994. V. 51. P. 536-540.Boy ages S.C. Iodine deficiency disorders // J Clin Endocrinol Metab. 1993. V. 77. P. 587-591.Boy ages S.C. Iodine deficiency disorders // J Clin Endocrinol Metab. 1993. V. 77. P. 587-591.Byrne J.J., Carborne J., Hanson E. Hypothyroidism and abnormalities in the kinetics of thyroid hormone metabolism in rats treated chronically with polychlorinated biphenyl and polybrominated biphenyl // Endocrinology. 1987. V. 21. P. 520-527.Byrne J.J., Carborne J., Hanson E. Hypothyroidism and abnormalities in the kinetics of thyroid hormone metabolism in rats treated chronically with polychlorinated biphenyl and polybrominated biphenyl // Endocrinology. 1987. V. 21. P. 520-527.Chang T.C., Chen W.L., Chang E.P. et al. Effect of prolonged radiation exposure on the thyroid gland of residents living in 60Co-contaminated buildings // Int J Radiat Biol. 2001. V. 77. P. 1117-1122.Chang T.C., Chen W.L., Chang E.P. et al. Effect of prolonged radiation exposure on the thyroid gland of residents living in 60Co-contaminated buildings // Int J Radiat Biol. 2001. V. 77. P. 1117-1122.Christensen J.M., Poulsen O.M. A 1982-1992 suveillance programme on Danish pottery painters. Biological levels and health effects following exposure to soluble or insoluble cobalt compounds in cobalt blue dyes // Sci Total Environ. 1994. V. 150. P. 95-104.Christensen J.M., Poulsen O.M. A 1982-1992 suveillance programme on Danish pottery painters. Biological levels and health effects following exposure to soluble or insoluble cobalt compounds in cobalt blue dyes // Sci Total Environ. 1994. V. 150. P. 95-104.Colin I.M., Nava E., Toussaint D. et al. Expression of nitric oxide synthase isoforms in the thyroid gland: evidence for a role of nitric oxide in vascular control during goiter formation. // Endocrinology. 1995. V. 136. P. 5283-5290.Colin I.M., Nava E., Toussaint D. et al. Expression of nitric oxide synthase isoforms in the thyroid gland: evidence for a role of nitric oxide in vascular control during goiter formation. // Endocrinology. 1995. V. 136. P. 5283-5290.Cornelis S., Uttenweiler-Joseph S., Panneels V. et al. Purification and characterization of a soluble bioactive amino-terminal extracellular domain of the human thyrotropin receptor // Boichemistry. 2001. V. 40. P. 9860-9869.Cornelis S., Uttenweiler-Joseph S., Panneels V. et al. Purification and characterization of a soluble bioactive amino-terminal extracellular domain of the human thyrotropin receptor // Boichemistry. 2001. V. 40. P. 9860-9869.Costamagna M.E., Cabanillas A.M., Coleoni A.H. et al. Nitric oxide donors inhibit iodide transport and organification and induce morphological changes in cultured bovine thyroid cells // Thyroid. 1998. V. 8. P. 1127-1135.Costamagna M.E., Cabanillas A.M., Coleoni A.H. et al. Nitric oxide donors inhibit iodide transport and organification and induce morphological changes in cultured bovine thyroid cells // Thyroid. 1998. V. 8. P. 1127-1135.Donnini D., Ambesi-Impiombato F.S., Curcio F. Thyrotropin stimulates production of procoagulant and vasodilatative factors in human aortic endothelial cells // Thyroid. 2003. V. 13. P. 517-521.Donnini D., Ambesi-Impiombato F.S., Curcio F. Thyrotropin stimulates production of procoagulant and vasodilatative factors in human aortic endothelial cells // Thyroid. 2003. V. 13. P. 517-521.Ellingsen D.G., Efskind J., Haung E. et al. Effects of low mercury vapour exposure on the thyroid function in chloralkali workers // J Appl Toxicol. 2000. V. 20. P. 483-489.Ellingsen D.G., Efskind J., Haung E. et al. Effects of low mercury vapour exposure on the thyroid function in chloralkali workers // J Appl Toxicol. 2000. V. 20. P. 483-489.Falk S.A. Thyroid disease (Endocrinology, Surgery, Nuclear Medicine, and Radiotherapy). Second Edition. 1997. P. 432.Falk S.A. Thyroid disease (Endocrinology, Surgery, Nuclear Medicine, and Radiotherapy). Second Edition. 1997. P. 432.Fukuyama K., Ichiki T., Takeda K. et al. Downregulation of vascular angiotensin II type 1 receptor by thyroid hormone // Hypertension. 2003. V. 87. P. 5636-5640.Fukuyama K., Ichiki T., Takeda K. et al. Downregulation of vascular angiotensin II type 1 receptor by thyroid hormone // Hypertension. 2003. V. 87. P. 5636-5640.Furlaneto T.W., Nguyen L.Q., Jameson J.L. Estradiol increases proliferation and down-regulates the sodium/iodide symporter gene in FRTL-5 cells // Endocrinology. 1999. V. 140. P. 5705-5711.Furlaneto T.W., Nguyen L.Q., Jameson J.L. Estradiol increases proliferation and down-regulates the sodium/iodide symporter gene in FRTL-5 cells // Endocrinology. 1999. V. 140. P. 5705-5711.Gaitan E., Cooksey P.C., Legan J. et al. Antithyroid and goitrogenic effects of coal-water extracts from iodine-sufficient goiter areas // Thyroid. 1993. V. 3. P. 49-53.Gaitan E., Cooksey P.C., Legan J. et al. Antithyroid and goitrogenic effects of coal-water extracts from iodine-sufficient goiter areas // Thyroid. 1993. V. 3. P. 49-53.Iitaka M., Kakinuma S., Fujimaki S. et al. Induction of apoptosis and necrosis by zinc in human thyroid cancer cell lines // J Endocrinol. 2001. V. 169. P. 417-424.Iitaka M., Kakinuma S., Fujimaki S. et al. Induction of apoptosis and necrosis by zinc in human thyroid cancer cell lines // J Endocrinol. 2001. V. 169. P. 417-424.Kavlock R.J., Daston G.P., DeRosa C. et al. Research needs for the risk assessment of health and environmental effects of endocrine disruptors: A report of the U.S. EPA-sponsored workshop // Environ Health Respect. 1996. V. 104. P. 715-740.Kavlock R.J., Daston G.P., DeRosa C. et al. Research needs for the risk assessment of health and environmental effects of endocrine disruptors: A report of the U.S. EPA-sponsored workshop // Environ Health Respect. 1996. V. 104. P. 715-740.Kececi T., Keskin E. Zinc Supplementation decreases total thyroid hormone concentration in small ruminants // Acta Vet Hung. 2002. V. 50. Р 93-100.Kececi T., Keskin E. Zinc Supplementation decreases total thyroid hormone concentration in small ruminants // Acta Vet Hung. 2002. V. 50. Р 93-100.Knudsen N., Laurberg P., Perrild H. et al. Risk factors for goiter and thyroid nodules // Thyroid. 2002. V. 12. P. 879-888.Knudsen N., Laurberg P., Perrild H. et al. Risk factors for goiter and thyroid nodules // Thyroid. 2002. V. 12. P. 879-888.Kochabati L., Boussen H., Benna F. et al. Second Malignancies folloeing Hodgkins disease treatment in Tunisia. Retrospective study of 26 cases observed at the institute Salah-Azaiz // Cancer Radiother. 2003. V. 7. P. 302-307.Kochabati L., Boussen H., Benna F. et al. Second Malignancies folloeing Hodgkins disease treatment in Tunisia. Retrospective study of 26 cases observed at the institute Salah-Azaiz // Cancer Radiother. 2003. V. 7. P. 302-307.Kohrle J. Flavonoids as a risk factor for goiter and hypothyroidism. Merck European Thyroid Symposium. 2000. P. 41- 53.Kohrle J. Flavonoids as a risk factor for goiter and hypothyroidism. Merck European Thyroid Symposium. 2000. P. 41- 53.Kohrle J. The trace element selenium and the thyroid gland // Biochimie. 1999. V. 81. P. 527-533.Kohrle J. The trace element selenium and the thyroid gland // Biochimie. 1999. V. 81. P. 527-533.Kramer A., Meng W., Reinwein D. et al. Experimental and epidemiological studies on the interrelationship of thiocyanate and thyroid function // Z Gesamte Hyg. 1990. V. 36. P. 383-387.Kramer A., Meng W., Reinwein D. et al. Experimental and epidemiological studies on the interrelationship of thiocyanate and thyroid function // Z Gesamte Hyg. 1990. V. 36. P. 383-387.Kvicala J., Zamrazil V. Effect of iodine and selenium upon thyroid function // Cent Eur J Public Health. 2003. V. 11. P. 107-113.Kvicala J., Zamrazil V. Effect of iodine and selenium upon thyroid function // Cent Eur J Public Health. 2003. V. 11. P. 107-113.Langer P., Tajtakova M., Kocan A. et al. Industrial pollution by polychlorinated biphenyls and the thyroid status of adult and adolescent populations. Merck European Thyroid Symposium. 2000. P. 79-91.Langer P., Tajtakova M., Kocan A. et al. Industrial pollution by polychlorinated biphenyls and the thyroid status of adult and adolescent populations. Merck European Thyroid Symposium. 2000. P. 79-91.Liang Q.R., Liao R.Q., Su S.H. et al. Effects of lead on thyroid function of occupationally exposed workers // Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2003. V. 21. P. 111-113.Liang Q.R., Liao R.Q., Su S.H. et al. Effects of lead on thyroid function of occupationally exposed workers // Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2003. V. 21. P. 111-113.Lindsay R.H., Hill J.B., Gaitan E. at al. Antithyroid effects of coalderived pollutants // J Toxicol Environ Health. 1992. V. 37. P. 467-481.Lindsay R.H., Hill J.B., Gaitan E. at al. Antithyroid effects of coalderived pollutants // J Toxicol Environ Health. 1992. V. 37. P. 467-481.Lopez-Aparicio O., Merino M., Sanchez E. et al. Effect of Aroclor 1248 and two pure congeners upon the membrane fluidity of rat renal tubular cultures // Pesticide Biochem Physiol. 1997. V. 57. P. 54-62.Lopez-Aparicio O., Merino M., Sanchez E. et al. Effect of Aroclor 1248 and two pure congeners upon the membrane fluidity of rat renal tubular cultures // Pesticide Biochem Physiol. 1997. V. 57. P. 54-62.Michalek J.E., Akhtar F.Z., Kiel J.L. Serum dioxin, insulin, fasting glucose and sex-hormone binding globulin in veterans of operation Ranch Hand // J Clin Endocrinol Metab. 1999. V. 84. P. 1540-1543.Michalek J.E., Akhtar F.Z., Kiel J.L. Serum dioxin, insulin, fasting glucose and sex-hormone binding globulin in veterans of operation Ranch Hand // J Clin Endocrinol Metab. 1999. V. 84. P. 1540-1543.Moreno-Reyes R., Mathieu F, Boelaert M. et al. Selenium and iodine supplementation of rural Tibetan children affected by Kashin-Beck osteoarthropathy // Am J Clin Nutr. 2003. V. 78. P. 137-144.Moreno-Reyes R., Mathieu F, Boelaert M. et al. Selenium and iodine supplementation of rural Tibetan children affected by Kashin-Beck osteoarthropathy // Am J Clin Nutr. 2003. V. 78. P. 137-144.Movius E.G., Phyillaier M.M., Robbins J. Phloretin inhibits cellular uptake and nuclear receptor binding of triiodothyronine in human Hep G2 hepatocarcinoma cells // Endocrinology. 1989. V. 124. P. 1988-1997.Movius E.G., Phyillaier M.M., Robbins J. Phloretin inhibits cellular uptake and nuclear receptor binding of triiodothyronine in human Hep G2 hepatocarcinoma cells // Endocrinology. 1989. V. 124. P. 1988-1997.Patel A., Fenton C., Terrell R. et al. Nitrotyrosine, inducible nitric oxid synthase (iNOS), and endothelial nitric oxide synthase (e NOS) are increased in thyroid tumors from children and adolescents // J Endocrinol Invest. 2002. V. 25. P. 675-683.Patel A., Fenton C., Terrell R. et al. Nitrotyrosine, inducible nitric oxid synthase (iNOS), and endothelial nitric oxide synthase (e NOS) are increased in thyroid tumors from children and adolescents // J Endocrinol Invest. 2002. V. 25. P. 675-683.Peltova V., Mantyla E., Huhtaniemi I. et al. Lipid peroxidation and antioxidant enzyme activities in the rat testis after cigarette smoke inhalation or administration of polychlorinated biphenils or polychlorinated naphtalens // J Andrology. - 1994. V. 15. P. 353-361.Peltova V., Mantyla E., Huhtaniemi I. et al. Lipid peroxidation and antioxidant enzyme activities in the rat testis after cigarette smoke inhalation or administration of polychlorinated biphenils or polychlorinated naphtalens // J Andrology. - 1994. V. 15. P. 353-361.Regalbuto C., Squatrito S., La Rosa G.L. et al. Longitudinal study on goiter prevalence and goitrogen factors in northeastern Sicily // J Endocrinol Invest.1996. V. 19. P. 638-645.Regalbuto C., Squatrito S., La Rosa G.L. et al. Longitudinal study on goiter prevalence and goitrogen factors in northeastern Sicily // J Endocrinol Invest.1996. V. 19. P. 638-645.Revaglia G., Forti P., Maioli F. et al. Blood micronutrient and thyroid hormone concentrations in the oldest-old // J Clin Endocrinol Metab. 2000. V. 85. P. 2260-2265.Revaglia G., Forti P., Maioli F. et al. Blood micronutrient and thyroid hormone concentrations in the oldest-old // J Clin Endocrinol Metab. 2000. V. 85. P. 2260-2265.Shakir K.M., Chute J.P., Aprill B.S., Lazarus A.A. Ferrous sulfate-induced increase in requirement for thyroxine in a patient with primary hypothyroidism // South Med J. 1997. V. 90. P. 637-639.Shakir K.M., Chute J.P., Aprill B.S., Lazarus A.A. Ferrous sulfate-induced increase in requirement for thyroxine in a patient with primary hypothyroidism // South Med J. 1997. V. 90. P. 637-639.Sourgens H, Winterhoff H., Gumbinger H. et al. Antihormonal effects of plant extracts: TSH- and prolactin suppressing properties of Lithospermum officinale and other plants // Planta Med. 1982. V. 45. P. 78.Sourgens H, Winterhoff H., Gumbinger H. et al. Antihormonal effects of plant extracts: TSH- and prolactin suppressing properties of Lithospermum officinale and other plants // Planta Med. 1982. V. 45. P. 78.Spanka M., Hesch R., Irmscher K. et al. 5-Deiodination in rat hepatocetes: Effects of specific flavonoid inhibitors // Endocrinology. 1990. V. 126. P. 1660-1667.Spanka M., Hesch R., Irmscher K. et al. 5-Deiodination in rat hepatocetes: Effects of specific flavonoid inhibitors // Endocrinology. 1990. V. 126. P. 1660-1667.Taddei S., Caraccio N., Virdis A. et al. Impaired Endothelin-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy // J Clin Endocrinol Metab. 2003. V. 88. P. 3731-3737.Taddei S., Caraccio N., Virdis A. et al. Impaired Endothelin-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy // J Clin Endocrinol Metab. 2003. V. 88. P. 3731-3737.Tereshenko I.V., Goldyreva T.P., Bronnikov V.I. Trace elements and endemic goiter // Klin Med. 2004. V. 82. P. 62-68.Tereshenko I.V., Goldyreva T.P., Bronnikov V.I. Trace elements and endemic goiter // Klin Med. 2004. V. 82. P. 62-68.Tienboon P., Unachak K. Iron deficiency anaemia in childhood and thyroid function // Asia Pac J Clin Nutr. 2003. V. 12. P. 198-202.Tienboon P., Unachak K. Iron deficiency anaemia in childhood and thyroid function // Asia Pac J Clin Nutr. 2003. V. 12. P. 198-202.Tong Y.J., Teng W.P., Jin Y. et al. An epidemiological study on the relationship between selenium and thyroid function in areas with different iodine intake // Zhonghua Yi Xue Za Zhi. 2003. V. 10, 83. P. 2036-2039.Tong Y.J., Teng W.P., Jin Y. et al. An epidemiological study on the relationship between selenium and thyroid function in areas with different iodine intake // Zhonghua Yi Xue Za Zhi. 2003. V. 10, 83. P. 2036-2039.Vial T., Nicolas B., Descortes J. Clinical immunotoxicity of pesticides // J Toxicol Environ Health. 1996. V. 48. P. 215-229.Vial T., Nicolas B., Descortes J. Clinical immunotoxicity of pesticides // J Toxicol Environ Health. 1996. V. 48. P. 215-229.Winterhoff H. Arzneipflanzen mit endokriner Wirksamkeit -Auswirkungen auf Schilddrusen- und Ovarfunktion // Zeitschrift fur Phytotherapie. 1993. V. 14. P. 83-94.Winterhoff H. Arzneipflanzen mit endokriner Wirksamkeit -Auswirkungen auf Schilddrusen- und Ovarfunktion // Zeitschrift fur Phytotherapie. 1993. V. 14. P. 83-94.Winterhoff H., Gumbinger H., Vahlensiek U. et al. Endocrine effects of Lycopus europaeus L. following oral application // Arzneimittelforschung. 1994. V. 44. P. 41-45.Winterhoff H., Gumbinger H., Vahlensiek U. et al. Endocrine effects of Lycopus europaeus L. following oral application // Arzneimittelforschung. 1994. V. 44. P. 41-45.Winterhoff H., Sourgens H., Kemper F.H.Antihormonal effects of plant extracts - pharmacodynamic effects of Lithospermum officinale on the thyroid gland of rats; comparison with effects of iodide // Horm Metab Res. 1983. V. 15. P. 503-507.Winterhoff H., Sourgens H., Kemper F.H.Antihormonal effects of plant extracts - pharmacodynamic effects of Lithospermum officinale on the thyroid gland of rats; comparison with effects of iodide // Horm Metab Res. 1983. V. 15. P. 503-507.Yin F., Giuliano A.E., Van Herle A.J. Growth inhibitory effects of flavonoids in human thyroid cancer cell lines // Thyroid. 1999. V. 9. P. 369-376.Yin F., Giuliano A.E., Van Herle A.J. Growth inhibitory effects of flavonoids in human thyroid cancer cell lines // Thyroid. 1999. V. 9. P. 369-376.Yin F., Giuliano A.E., Van Herle A.J. Signal pathways involved in apigenin inhibition of growth and inducation of apoptosis of human anaplastic thyroid cancer cells // Anticancer Res. 1999. V. 19. P. 4297-4303.Yin F., Giuliano A.E., Van Herle A.J. Signal pathways involved in apigenin inhibition of growth and inducation of apoptosis of human anaplastic thyroid cancer cells // Anticancer Res. 1999. V. 19. P. 4297-4303.Zagrodzki P., Szmigiel H., Ratajczak Z. et al. The role of selenium in iodine metabolism in children with goiter // Environ Health Respect. 2000. V. 108. P. 67-71.Zagrodzki P., Szmigiel H., Ratajczak Z. et al. The role of selenium in iodine metabolism in children with goiter // Environ Health Respect. 2000. V. 108. P. 67-71.Zimmermann M.B. Iron Status influences the efficacy of iodine prophylaxis in goitrous children in Cote dIvoire // Int J Vitam Res. 2002. V. 72. P. 19-25.Zimmermann M.B. Iron Status influences the efficacy of iodine prophylaxis in goitrous children in Cote dIvoire // Int J Vitam Res. 2002. V. 72. P. 19-25.

The authors declare that there are no conflicts of interest present.