ketendoКлиническая и экспериментальная тиреоидологияClinical and experimental thyroidology1995-54722310-3787Endocrinology Research Centre10.14341/ket20139142-45ketendo-6346Research ArticleСтатьиArticlesРаспространенность гипотиреоза в группе детей и подростков с сахарным диабетом по результатам селективного скринингаPrevalence of hypothyroidism among children and adolescents with diabetes mellitus by results of selective screeningAlexandrovK A

аспирант кафедры педиатрии ФПК и ПП ГБОУ ВПО “УГМА” МЗ РФ

-KiyaevA V

доктор мед. наук, доцент кафедры педиатрии ФПК и ПП ГБОУ ВПО “УГМА” МЗ РФ, начальник отдела эндокринологии ГБУЗ СО “ОДКБ № 1”, главный детский эндокринолог МЗ Свердловской области

thyroend@mail.ruKovtunO P

доктор мед. наук, профессор, заведующая кафедрой педиатрии ФПК и ПП ГБОУ ВПО “УГМА” МЗ РФ, проректор УГМА по научной работе

-BelyaevaS V

канд. мед. наук, заведующая биохимической лабораторией МУ “КДЦ”

-20131503201391ТОМ 39, №1 (2013)4245Copyright © Alexandrov K.A., Kiyaev A.V., Kovtun O.P., Belyaeva S.V., 20132013Alexandrov K.A., Kiyaev A.V., Kovtun O.P., Belyaeva S.V.Alexandrov K.A., Kiyaev A.V., Kovtun O.P., Belyaeva S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cet-endojournals.ru/jour/article/view/6346

Цель исследования: установить распространенность гипотиреоза в группе детей и подростков с сахарным диабетом 1-го типа по результатам селективного скрининга. Материал и методы. Обследовано 132 ребенка (64 девочки, 68 мальчиков) в возрасте от 1 года до 17,5 лет. Проведено УЗИ ЩЖ с определением тиреоидного объема и структуры, а также определение ТТГ, АТТПО и св. Т4, при уровне ТТГ, вы ходящем за референсные интервалы. Результаты. Распространенность явного гипотиреоза (7,6%) в исходе АИТ у детей с СД оказалась выше, чем в общей популяции, что подтверждает эффективность селективного скрининга в этой группе детей и диктует необходимость его внедрения в рутинную клиническую практику; высокая частота антителоносительства к ТПО (12,8%) требует уточнения их прогностического значения в процессе длительного динамического наблюдения, а также пересмотра точки разделения между патологией и нормой.

Establish the prevalence of hypothyroidism among children with diabetes mellitus (DM) as a result of selective screening. During the examination period 132 children (64 f/68 m) aged from 1.0 to 17.5 years were examined. Ultrasonography evaluation, including measurement of thyroid volume, was performed in all volunteers as well as analysis of TSH, TPOAb and fT4 when TSH was out of reference range. The prevalence of overt hypothyroidism (7,6%) in the outcome of AIT in children with DM was above the population level, which confirms the effective of selective screening in this group of children and demands to its introduction into routine clinical practice; high incidence of TPOAb (12.8%) need to clarify their prognostic value having regard to longterm followup, as well as revising of dividing cutofpoint.

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The authors declare that there are no conflicts of interest present.