<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ketendo</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая и экспериментальная тиреоидология</journal-title><trans-title-group xml:lang="en"><trans-title>Clinical and experimental thyroidology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5472</issn><issn pub-type="epub">2310-3787</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/ket20139315-20</article-id><article-id custom-type="elpub" pub-id-type="custom">ketendo-6359</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Гипопитуитаризм после облучения гипоталамогипофизарной системы</article-title><trans-title-group xml:lang="en"><trans-title>Hypopituitarism after radiotherapy for childhood malignant tumors</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Bobrova</surname><given-names>E I</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры эндокринологии ГБОУ ВПО “Первый МГМУ им. И.М. Сеченова” МЗ РФ</p></bio><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Pavlova</surname><given-names>M G</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, ассистент кафедры эндокринологии ГБОУ ВПО “Первый МГМУ им. И.М. Сеченова” МЗ РФ</p></bio><email xlink:type="simple">mgpavlova68@rambler.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Sotnikov</surname><given-names>V M</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, профессор, ведущий научный сотрудник ФГБУ “Российский научный центр рентгенорадиологии” МЗ РФ</p></bio><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Pronin</surname><given-names>V S</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, профес сор кафедры эндокринологии ГБОУ ВПО “Первый МГМУ им. И.М. Сеченова” МЗ РФ</p></bio><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Fadeev</surname><given-names>V V</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, профессор, заведующий кафедрой эндокринологии ГБОУ ВПО “Первый МГМУ им. И.М. Сеченова” МЗ РФ</p></bio><email xlink:type="simple">-</email></contrib></contrib-group><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>15</day><month>09</month><year>2013</year></pub-date><volume>9</volume><issue>3</issue><issue-title>ТОМ 9, №3 (2013)</issue-title><fpage>15</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Bobrova E.I., Pavlova M.G., Sotnikov V.M., Pronin V.S., Fadeev V.V., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Bobrova E.I., Pavlova M.G., Sotnikov V.M., Pronin V.S., Fadeev V.V.</copyright-holder><copyright-holder xml:lang="en">Bobrova E.I., Pavlova M.G., Sotnikov V.M., Pronin V.S., Fadeev V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.cet-endojournals.ru/jour/article/view/6359">https://www.cet-endojournals.ru/jour/article/view/6359</self-uri><abstract><p>В настоящее время краниальное облучение (КО) применяется в комплексной терапии первичных опу холей головного мозга, опухолей гипоталамогипо физарной области, назофарингеальных опухолей, опухолей основания черепа, лица и шеи, а также для профилактики нейролейкемии у больных острым лимфобластным лейкозом (ОЛЛ) и при тотальном облучении перед пересадкой костного мозга.</p></abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Rutka JT, Hoffman HJ. Medulloblastoma: a historical perspective and overview. J Neurooncol. 1996;29(1):17.</mixed-citation><mixed-citation xml:lang="en">Rutka JT, Hoffman HJ. Medulloblastoma: a historical perspective and overview. J Neurooncol. 1996;29(1):17.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffman KE, Yock TI. Radiation therapy for pediatric central nervous system tumors. J Child Neurol. 2009;24(11):13871396.</mixed-citation><mixed-citation xml:lang="en">Hoffman KE, Yock TI. Radiation therapy for pediatric central nervous system tumors. J Child Neurol. 2009;24(11):13871396.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Schneider HJ, Rovere S, Corneli G et al. Endocrine dysfunction in patients operated on for nonpituitary intracranial tumors. Eur J Endocrinol. 2006;15:559566.</mixed-citation><mixed-citation xml:lang="en">Schneider HJ, Rovere S, Corneli G et al. Endocrine dysfunction in patients operated on for nonpituitary intracranial tumors. Eur J Endocrinol. 2006;15:559566.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Brada M, Ashley S, Ford D et al. Cerebrovascular mortality in patients with pituitary adenoma. Clin Endocrinol. 2002;5: 713717.</mixed-citation><mixed-citation xml:lang="en">Brada M, Ashley S, Ford D et al. Cerebrovascular mortality in patients with pituitary adenoma. Clin Endocrinol. 2002;5: 713717.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Tomlinson JW, Holden N, Hills RK et al. Association between pre mature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group. Lancet. 2001;357:425431.</mixed-citation><mixed-citation xml:lang="en">Tomlinson JW, Holden N, Hills RK et al. Association between pre mature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group. Lancet. 2001;357:425431.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gleeson HK, Shalet SM. The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours. Endocrine Related Cancer. 2004;11:589602.</mixed-citation><mixed-citation xml:lang="en">Gleeson HK, Shalet SM. The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours. Endocrine Related Cancer. 2004;11:589602.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Withers HR. Biology of radiation oncology; in Tobias JS, Thomas PRM (eds): Current Radiation Oncology. London, Edward Arnold, 1994;1:523.</mixed-citation><mixed-citation xml:lang="en">Withers HR. Biology of radiation oncology; in Tobias JS, Thomas PRM (eds): Current Radiation Oncology. London, Edward Arnold, 1994;1:523.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Pai HH, Thornton A, Katznelson L et al. Hypothalamic pituitary function following high-dose conformal radiotherapy to the base of skull: demonstration of a dose-effect relationship using dose-volume histogram analysis. J Radiat Oncol Biol Phys. 2001; 49:10791092.</mixed-citation><mixed-citation xml:lang="en">Pai HH, Thornton A, Katznelson L et al. Hypothalamic pituitary function following high-dose conformal radiotherapy to the base of skull: demonstration of a dose-effect relationship using dose-volume histogram analysis. J Radiat Oncol Biol Phys. 2001; 49:10791092.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Samaan NA, Vieto R, Schultz PN et al. Hypothalamic, pituitary and thyroid dysfunction after radiotherapy to the head and neck. Int J Radiat Oncol Biol Phys. 1982;8:18571867.</mixed-citation><mixed-citation xml:lang="en">Samaan NA, Vieto R, Schultz PN et al. Hypothalamic, pituitary and thyroid dysfunction after radiotherapy to the head and neck. Int J Radiat Oncol Biol Phys. 1982;8:18571867.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Chen MS, Lin FJ, Huang MJ et al. Prospective hormone study of hypothalamic pituitary function in patients with nasopharyngeal carcinoma after high dose irradiation. Jpn J Clin Oncol. 1989;19:265270.</mixed-citation><mixed-citation xml:lang="en">Chen MS, Lin FJ, Huang MJ et al. Prospective hormone study of hypothalamic pituitary function in patients with nasopharyngeal carcinoma after high dose irradiation. Jpn J Clin Oncol. 1989;19:265270.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hochberg Z, Kuten A, Hertz P et al. The effect of single dose radiation on cell survival and growth hormone secretion by rat anterior pituitary cells. Radiat Res. 1983;94:508512.</mixed-citation><mixed-citation xml:lang="en">Hochberg Z, Kuten A, Hertz P et al. The effect of single dose radiation on cell survival and growth hormone secretion by rat anterior pituitary cells. Radiat Res. 1983;94:508512.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Constine LS, Woolf PD, Cann D et al. Hypothalamic pituitary dysfunction after radiation for brain tumors. N Engl J Med. 1993; 328:8794.</mixed-citation><mixed-citation xml:lang="en">Constine LS, Woolf PD, Cann D et al. Hypothalamic pituitary dysfunction after radiation for brain tumors. N Engl J Med. 1993; 328:8794.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Clayton PE, Shalet SM. Dose dependency of time of onset of radiation-induced growth hormone deficiency. J Pediatr. 1991;118: 226228.</mixed-citation><mixed-citation xml:lang="en">Clayton PE, Shalet SM. Dose dependency of time of onset of radiation-induced growth hormone deficiency. J Pediatr. 1991;118: 226228.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Littley MD, Shalet SM, Beardwell CG et al. Radiation induced hypopituitarism is dose dependent. Clin Endocrinol Oxf. 1989; 31:363373.</mixed-citation><mixed-citation xml:lang="en">Littley MD, Shalet SM, Beardwell CG et al. Radiation induced hypopituitarism is dose dependent. Clin Endocrinol Oxf. 1989; 31:363373.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Lam KS, Tse VK, Wang C et al. Effects of cranial irradiation on hypothalamic-pituitary function – a 5year longitudinal study in patients with nasopharyngeal carcinoma. Q J Med. 1991;78: 165176.</mixed-citation><mixed-citation xml:lang="en">Lam KS, Tse VK, Wang C et al. Effects of cranial irradiation on hypothalamic-pituitary function – a 5year longitudinal study in patients with nasopharyngeal carcinoma. Q J Med. 1991;78: 165176.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Duffner PK, Cohen ME, Voorhess ML et al. Long-term effects of cranial irradiation on endocrine function in children with brain tumors. A prospective study. Cancer. 1985;56:21892193.</mixed-citation><mixed-citation xml:lang="en">Duffner PK, Cohen ME, Voorhess ML et al. Long-term effects of cranial irradiation on endocrine function in children with brain tumors. A prospective study. Cancer. 1985;56:21892193.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Endocrinopathy after childhood cancer treatment / volume editors, W.H.B. Wallace, C.J.H. Kelnarp.; cm. – (Endocrine development, ISSN 14217082; v. 15)</mixed-citation><mixed-citation xml:lang="en">Endocrinopathy after childhood cancer treatment / volume editors, W.H.B. Wallace, C.J.H. Kelnarp.; cm. – (Endocrine development, ISSN 14217082; v. 15)</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Schmiegelow M, Lassen S, Poulsen HS et al. Cranial radiotherapy of childhood brain tumours: growth hormone deficiency and its relation to the biological effective dose of irradiation in a large population based study. J Clin Endocrinol. 2000;53:191197.</mixed-citation><mixed-citation xml:lang="en">Schmiegelow M, Lassen S, Poulsen HS et al. Cranial radiotherapy of childhood brain tumours: growth hormone deficiency and its relation to the biological effective dose of irradiation in a large population based study. J Clin Endocrinol. 2000;53:191197.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ogilvy Stuart AL, Clark DJ, Wallace WH et al. Endocrine deficit after fractionated total body irradiation. Arch Dis Child. 1992; 67:11071110.</mixed-citation><mixed-citation xml:lang="en">Ogilvy Stuart AL, Clark DJ, Wallace WH et al. Endocrine deficit after fractionated total body irradiation. Arch Dis Child. 1992; 67:11071110.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Littley MD, Shalet SM, Morgenstern GR, Deakin DP. Endocrine and reproductive dysfunction following fractionated total body irradiation in adults. Q J Med. 1991;78:265274.</mixed-citation><mixed-citation xml:lang="en">Littley MD, Shalet SM, Morgenstern GR, Deakin DP. Endocrine and reproductive dysfunction following fractionated total body irradiation in adults. Q J Med. 1991;78:265274.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Brauner R, Czernichow P, Rappaport R. Greater susceptibility to hypothalamopituitary irradiation in younger children with acute lymphoblastic leukemia. J Pediatr. 1986;108:332.</mixed-citation><mixed-citation xml:lang="en">Brauner R, Czernichow P, Rappaport R. Greater susceptibility to hypothalamopituitary irradiation in younger children with acute lymphoblastic leukemia. J Pediatr. 1986;108:332.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Agha A, Sherlock M, Brennan S et al. Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults. J Clin Endocrinol Metab. 2005;90:63556360.</mixed-citation><mixed-citation xml:lang="en">Agha A, Sherlock M, Brennan S et al. Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults. J Clin Endocrinol Metab. 2005;90:63556360.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lam KSL, Tse VKS, Wang C et al. Early effects of cranial irradiation on hypothalamicpituitary function. J Clin Endocrinol Metab. 1987;64:418-424.</mixed-citation><mixed-citation xml:lang="en">Lam KSL, Tse VKS, Wang C et al. Early effects of cranial irradiation on hypothalamicpituitary function. J Clin Endocrinol Metab. 1987;64:418-424.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Littley MD, Shalet SM, Beardwell CG et al. Radiation and hypo thalamicpituitary function. Baillieres Clin Endocrinol Metab. 1990;4:147-175.</mixed-citation><mixed-citation xml:lang="en">Littley MD, Shalet SM, Beardwell CG et al. Radiation and hypo thalamicpituitary function. Baillieres Clin Endocrinol Metab. 1990;4:147-175.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Clayton PE, Cowel CT. Safety issues in children and adolescents during growth hormone therapy – a review. Growth Horm IGF Res. 2000;10(6):306-317.</mixed-citation><mixed-citation xml:lang="en">Clayton PE, Cowel CT. Safety issues in children and adolescents during growth hormone therapy – a review. Growth Horm IGF Res. 2000;10(6):306-317.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Shalet SM, Beardwell CG, Morris Jones PH et al. Growth hormone deficiency after treatment of acute leukemia in children. Arch Dis Child. 1976;51:489-494.</mixed-citation><mixed-citation xml:lang="en">Shalet SM, Beardwell CG, Morris Jones PH et al. Growth hormone deficiency after treatment of acute leukemia in children. Arch Dis Child. 1976;51:489-494.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Littley MD, Shalet SM, Beardwell CG et al. Hypopituitarism following external radiotherapy for pituitary tumours in adults. Q J Med.1989;262:145-160.</mixed-citation><mixed-citation xml:lang="en">Littley MD, Shalet SM, Beardwell CG et al. Hypopituitarism following external radiotherapy for pituitary tumours in adults. Q J Med.1989;262:145-160.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Laughton SJ, Merchant TE, Sklar CA et al. Endocrine outcomes for children with embryonal brain tumors after risk adapted cranio-spinal and conformal primarysite irradiation and high dose chemotherapy with stem-cell rescue on the SJMB96 trial. J Clin Oncol. 2008;26(7):1112-1118.</mixed-citation><mixed-citation xml:lang="en">Laughton SJ, Merchant TE, Sklar CA et al. Endocrine outcomes for children with embryonal brain tumors after risk adapted cranio-spinal and conformal primarysite irradiation and high dose chemotherapy with stem-cell rescue on the SJMB96 trial. J Clin Oncol. 2008;26(7):1112-1118.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Toogood AA. Endocrine consequences of brain irradiation. Growth. Hormone and IGF Research. 2004;14(Suppl A):S118S124.</mixed-citation><mixed-citation xml:lang="en">Toogood AA. Endocrine consequences of brain irradiation. Growth. Hormone and IGF Research. 2004;14(Suppl A):S118S124.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Chieng PU, Huang TS, Chang CC et al. Reduced hypothalamic blood flow after radiation treatment of nasopharyngeal cancer: SPECT studies in 34 patients. Am J Neuroradiol. 1991;12:661665.</mixed-citation><mixed-citation xml:lang="en">Chieng PU, Huang TS, Chang CC et al. Reduced hypothalamic blood flow after radiation treatment of nasopharyngeal cancer: SPECT studies in 34 patients. Am J Neuroradiol. 1991;12:661665.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Belka C, Budach W, Kortmann RD, Bamberg M. Radiation induced CNS toxicity – molecular and cellular mechanisms. Br J Cancer. 2001;85:12331239.</mixed-citation><mixed-citation xml:lang="en">Belka C, Budach W, Kortmann RD, Bamberg M. Radiation induced CNS toxicity – molecular and cellular mechanisms. Br J Cancer. 2001;85:12331239.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Dewey WC, Bedford JS. Radiobiologic principles. In Textbook of Radiation Oncology. Eds SA Leibel &amp; TL Phillips. Philadelphia: WB Saunders &amp;Company, 1998;325.</mixed-citation><mixed-citation xml:lang="en">Dewey WC, Bedford JS. Radiobiologic principles. In Textbook of Radiation Oncology. Eds SA Leibel &amp; TL Phillips. Philadelphia: WB Saunders &amp;Company, 1998;325.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Tofilon PJ, Fike JR. The radio response of the central nervous system: a dynamic process. Radiation Research. 2000;153:357370.</mixed-citation><mixed-citation xml:lang="en">Tofilon PJ, Fike JR. The radio response of the central nervous system: a dynamic process. Radiation Research. 2000;153:357370.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Spoudeas HA, Hindmarsh PC, Matthews DR et al. Evolution of growth hormone neurosecretory disturbance after cranial irradiation for childhood brain tumours: a prospective study. J Endocrinol.1996;150(2):329342.</mixed-citation><mixed-citation xml:lang="en">Spoudeas HA, Hindmarsh PC, Matthews DR et al. Evolution of growth hormone neurosecretory disturbance after cranial irradiation for childhood brain tumours: a prospective study. J Endocrinol.1996;150(2):329342.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Nishioka H, Ito H, Haraoka J, Hirano A. Histologicalchanges in the hypofunctional pituitary gland following conventional radiotherapy for adenoma. Histopathology. 2001;38:561566.</mixed-citation><mixed-citation xml:lang="en">Nishioka H, Ito H, Haraoka J, Hirano A. Histologicalchanges in the hypofunctional pituitary gland following conventional radiotherapy for adenoma. Histopathology. 2001;38:561566.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Rush S, Cooper PR. Symptom resolution, tumor control, and side effects following postoperative radiotherapy for pituitary macroadenomas. Int J Radiat Oncol Biol Phys. 1997;37:10311034.</mixed-citation><mixed-citation xml:lang="en">Rush S, Cooper PR. Symptom resolution, tumor control, and side effects following postoperative radiotherapy for pituitary macroadenomas. Int J Radiat Oncol Biol Phys. 1997;37:10311034.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Arlt W. HUMBea. Frequent and frequently overlooked: treatment induced endocrine dysfunction in adult long-term survivors of primary brain tumors. Neurology. 1997;49:498506.</mixed-citation><mixed-citation xml:lang="en">Arlt W. HUMBea. Frequent and frequently overlooked: treatment induced endocrine dysfunction in adult long-term survivors of primary brain tumors. Neurology. 1997;49:498506.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Goldman S, Turner CD. Late effects of treatment for brain tumors. Springer, 2009. ISBN 9780387771021.</mixed-citation><mixed-citation xml:lang="en">Goldman S, Turner CD. Late effects of treatment for brain tumors. Springer, 2009. ISBN 9780387771021.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace WHB, Kelnar CJH (eds). Endocrinopathy after Childhood Cancer Treatment. Endocr Dev. Basel, Karger. 2009;15:124.</mixed-citation><mixed-citation xml:lang="en">Wallace WHB, Kelnar CJH (eds). Endocrinopathy after Childhood Cancer Treatment. Endocr Dev. Basel, Karger. 2009;15:124.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Мазеркина НА. Эндокринные нарушения после комплексно го лечения злокачественных опухолей хиазмально-селлярной области и задней черепной ямки: дисс. ... дра мед. наук. Москва, 2007.</mixed-citation><mixed-citation xml:lang="en">Мазеркина НА. Эндокринные нарушения после комплексно го лечения злокачественных опухолей хиазмально-селлярной области и задней черепной ямки: дисс. ... дра мед. наук. Москва, 2007.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Hulshof MC, Schimmel EC, Bosch DA et al. Hypofractionation in glioblastoma multiforme. Radiotherapy and Oncology. 2000;54(2): 143148.</mixed-citation><mixed-citation xml:lang="en">Hulshof MC, Schimmel EC, Bosch DA et al. Hypofractionation in glioblastoma multiforme. Radiotherapy and Oncology. 2000;54(2): 143148.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Измайлов ТР, Паньшин ГА, Даценко ПВ. Роль функционального состояния и классов RPA в выборе режима фракционирования при лечении глиом высокой степени злокачественности. Вопросы онкологии. 2012;58(3):369373.</mixed-citation><mixed-citation xml:lang="en">Измайлов ТР, Паньшин ГА, Даценко ПВ. Роль функционального состояния и классов RPA в выборе режима фракционирования при лечении глиом высокой степени злокачественности. Вопросы онкологии. 2012;58(3):369373.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
