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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ketendo</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая и экспериментальная тиреоидология</journal-title><trans-title-group xml:lang="en"><trans-title>Clinical and experimental thyroidology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5472</issn><issn pub-type="epub">2310-3787</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/CET20141019-20</article-id><article-id custom-type="elpub" pub-id-type="custom">ketendo-6635</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Дефицит йода, формирование и развитие организма</article-title><trans-title-group xml:lang="en"><trans-title>Iodine Deficiency and Human Development</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Sviridonova</surname><given-names>M A</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, научный сотрудник отделения терапии с группой патологии метаболизма и ожирения ФГБУ ЭНЦ.; ФГБУ “Эндокринологический научный центр" Министерства здравоохранения России, Москва</p></bio><email xlink:type="simple">maska119@rambler.ru</email></contrib></contrib-group><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>15</day><month>03</month><year>2014</year></pub-date><volume>10</volume><issue>1</issue><issue-title>ТОМ 10, №1 (2014)</issue-title><fpage>9</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Sviridonova M.A., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Sviridonova M.A.</copyright-holder><copyright-holder xml:lang="en">Sviridonova M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.cet-endojournals.ru/jour/article/view/6635">https://www.cet-endojournals.ru/jour/article/view/6635</self-uri><abstract><p>Йод относится к жизненно важным микроэлементам, без которых невозможно нормальное формирование и функционирование человеческого организма. Дефицит йода - глобальная проблема: по различным оценкам, около 2 миллиардов людей во всем мире страдают от недостаточного потребления йода. Несмотря на то что зоб является наиболее визуально заметным проявлением йододефицита, к самым значимым его последствиям относятся нарушения развития центральной нервной системы, особенно в раннем детском возрасте. Кроме того, на фоне умеренного и тяжелого дефицита йода повышается риск спонтанного прерывания беременности, низкой массы тела новорожденных, младенческой смертности. У детей, внутриутробно пострадавших от дефицита йода, повышен риск нарушений умственного развития, крайней степенью которых является кретинизм. Кроме того, умеренный и тяжелый йододефицит в детском возрасте отрицательно сказывается на физическом развитии. Восполнение йододефицита оказывает благоприятное влияние на процессы формирования и развития организма. При этом йодная профилактика является чрезвычайно эффективным подходом к снижению неблагоприятных последствий дефицита йода в любом возрасте.</p></abstract><trans-abstract xml:lang="en"><p>Iodine is а vital microelements that are essential for the normal human development and functions. Iodine deficiency is a global problem: about 2 billion individuals worldwide suffer from a lack of iodine. Despite goiter is the most visually noticeable manifestation of iodine deficiency, the most significant consequence of the iodine deficiency is impaired neurodevelopment, particularly early in life. Moreover, moderate to severe iodine deficiency increases the risk of spontaneous abortion, low birth weight and infant mortality. Babies in utero affected by iodine deficiency are at increased risk of mental developmental disorders, cretinism is their extreme degree. In addition, moderate to severe iodine deficiency in childhood negatively affects somatic growth. Iodine deficiency compensation improves cognitive and motor function in children. Iodine prophylaxis of deficient populations is an extremely effective approach to reduce the substantial adverse effects of iodine deficiency throughout the life cycle.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дефицит йода</kwd><kwd>умственное развитие</kwd><kwd>кретинизм</kwd><kwd>физическое развитие</kwd></kwd-group><kwd-group xml:lang="en"><kwd>iodine deficiency</kwd><kwd>cognitive development</kwd><kwd>cretinism</kwd><kwd>growth</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hetzel BS. Iodine deficiency disorders (IDD) and their eradication. Lancet. 1983;2:1126-1129.</mixed-citation><mixed-citation xml:lang="en">Hetzel BS. Iodine deficiency disorders (IDD) and their eradication. Lancet. 1983;2:1126-1129.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmermann MB, Jooste PL, Pandav CS. Iodine-deficiency disorders. Lancet. 2008;372:1251-1262.</mixed-citation><mixed-citation xml:lang="en">Zimmermann MB, Jooste PL, Pandav CS. Iodine-deficiency disorders. Lancet. 2008;372:1251-1262.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Andersson M, de Benoist B, Rogers L. Epidemiology of iodine deficiency: salt iodisation and iodine status. Best Pract Res Clin Endocrinol Metab. 2010;24(1):1-11.</mixed-citation><mixed-citation xml:lang="en">Andersson M, de Benoist B, Rogers L. Epidemiology of iodine deficiency: salt iodisation and iodine status. Best Pract Res Clin Endocrinol Metab. 2010;24(1):1-11.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">de Benoist B, McLean E, Andersson M, Rogers L. Iodine deficiency in 2007: global progress since 2003. Food Nutr Bull. 2008;29:195-202.</mixed-citation><mixed-citation xml:lang="en">de Benoist B, McLean E, Andersson M, Rogers L. Iodine deficiency in 2007: global progress since 2003. Food Nutr Bull. 2008;29:195-202.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Дефицит йода - угроза здоровью и развитию детей России. Пути решения проблемы. Национальный доклад. М., 2006.</mixed-citation><mixed-citation xml:lang="en">Дефицит йода - угроза здоровью и развитию детей России. Пути решения проблемы. Национальный доклад. М., 2006.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Абдулхабирова ФМ. Профилактика йододефицитных заболеваний у детей. Педиатрия. 2010;4.</mixed-citation><mixed-citation xml:lang="en">Абдулхабирова ФМ. Профилактика йододефицитных заболеваний у детей. Педиатрия. 2010;4.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization UNCsF, International Council for Control of Iodine Deficiency Disorders. Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. 3rd ed. Geneva: World Health Organization; 2007.</mixed-citation><mixed-citation xml:lang="en">World Health Organization UNCsF, International Council for Control of Iodine Deficiency Disorders. Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. 3rd ed. Geneva: World Health Organization; 2007.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Alexander W, Harden R, Harrison M, Shimmins J. Some aspects of the absorption and concentration of iodide by the alimentary tract in man. Proc Nutr Soc. 1967;26:62-66.</mixed-citation><mixed-citation xml:lang="en">Alexander W, Harden R, Harrison M, Shimmins J. Some aspects of the absorption and concentration of iodide by the alimentary tract in man. Proc Nutr Soc. 1967;26:62-66.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Nath SK, Moinier B, Thuillier F et al. Urinary excretion of iodide and fluoride from supplemented food grade salt. Int J Vitam Nutr Res. 1992;62:66-72.</mixed-citation><mixed-citation xml:lang="en">Nath SK, Moinier B, Thuillier F et al. Urinary excretion of iodide and fluoride from supplemented food grade salt. Int J Vitam Nutr Res. 1992;62:66-72.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Fisher DA, Oddie TH. Thyroid iodine content and turnover in euthyroid subjects - validity of estimation of thyroid iodine accumulation from short-term clearance studies. J Clin Endocr Metab. 1969;29:721-727.</mixed-citation><mixed-citation xml:lang="en">Fisher DA, Oddie TH. Thyroid iodine content and turnover in euthyroid subjects - validity of estimation of thyroid iodine accumulation from short-term clearance studies. J Clin Endocr Metab. 1969;29:721-727.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Degroot LJ. Kinetic analysis of iodine metabolism. J Clin Endocr Metab. 1966;26:149-173.</mixed-citation><mixed-citation xml:lang="en">Degroot LJ. Kinetic analysis of iodine metabolism. J Clin Endocr Metab. 1966;26:149-173.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Stanbury JB. The adaptation of man to iodine deficiency. Cambridge, MA: Harvard University Press; 1954. p. 1-209.</mixed-citation><mixed-citation xml:lang="en">Stanbury JB. The adaptation of man to iodine deficiency. Cambridge, MA: Harvard University Press; 1954. p. 1-209.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Delange F. Iodine deficiency. In: Braverman L, Utiger R, eds. Werner and Ingbar’s the thyroid: a fundamental and clinical text. Philadelphia: JD Lippincott; 2000. p. 295-316.</mixed-citation><mixed-citation xml:lang="en">Delange F. Iodine deficiency. In: Braverman L, Utiger R, eds. Werner and Ingbar’s the thyroid: a fundamental and clinical text. Philadelphia: JD Lippincott; 2000. p. 295-316.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev. 1997;18:404-433.</mixed-citation><mixed-citation xml:lang="en">Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev. 1997;18:404-433.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bernal J. Thyroid hormones and brain development. Vitam Horm. 2005;71:95-122.</mixed-citation><mixed-citation xml:lang="en">Bernal J. Thyroid hormones and brain development. Vitam Horm. 2005;71:95-122.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Flamant F, Samarut J. Thyroid hormone receptors: lessons from knockout and knock-in mutant mice. Trends Endocrin Met. 2003;14:85-90.</mixed-citation><mixed-citation xml:lang="en">Flamant F, Samarut J. Thyroid hormone receptors: lessons from knockout and knock-in mutant mice. Trends Endocrin Met. 2003;14:85-90.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Davis PJ, Davis FB, Cody V. Membrane receptors mediating thyroid hormone action. Trends Endocrin Met. 2005;16:429-435.</mixed-citation><mixed-citation xml:lang="en">Davis PJ, Davis FB, Cody V. Membrane receptors mediating thyroid hormone action. Trends Endocrin Met. 2005;16:429-435.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Zoeller RT, Rovet J. Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings. J Neuroendocrinol. 2004;16:809-818.</mixed-citation><mixed-citation xml:lang="en">Zoeller RT, Rovet J. Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings. J Neuroendocrinol. 2004;16:809-818.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Benowitz LI, Routtenberg A. GAP-43: an intrinsic determinant of neuronal development and plasticity. Trends Neurosci. 1997; 20:84-91.</mixed-citation><mixed-citation xml:lang="en">Benowitz LI, Routtenberg A. GAP-43: an intrinsic determinant of neuronal development and plasticity. Trends Neurosci. 1997; 20:84-91.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Huang KP, Huang FL, Jager T et al. Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling. J Neurosci. 2004;24:10660-10669.</mixed-citation><mixed-citation xml:lang="en">Huang KP, Huang FL, Jager T et al. Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling. J Neurosci. 2004;24:10660-10669.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Silva AJ, Paylor R, Wehner JM, Tonegawa S. Impaired spatial-learning in alpha-calcium-calmodulin kinase-II mutant mice. Science. 1992;257:206-211.</mixed-citation><mixed-citation xml:lang="en">Silva AJ, Paylor R, Wehner JM, Tonegawa S. Impaired spatial-learning in alpha-calcium-calmodulin kinase-II mutant mice. Science. 1992;257:206-211.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Gong J, Dong J, Wang Y et al. Developmental iodine deficiency and hypothyroidism impair neural development, up-regulate caveolin-1 and down-regulate synaptophysin in rat hippocampus. J Neuroendocrinol. 2010;22:129-139.</mixed-citation><mixed-citation xml:lang="en">Gong J, Dong J, Wang Y et al. Developmental iodine deficiency and hypothyroidism impair neural development, up-regulate caveolin-1 and down-regulate synaptophysin in rat hippocampus. J Neuroendocrinol. 2010;22:129-139.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">de Escobar GM, Obregon MJ, del Rey FE. Maternal thyroid hormones early in pregnancy and fetal brain development. Best Pract Res Clin Endocrinol Metab. 2004;18:225-248.</mixed-citation><mixed-citation xml:lang="en">de Escobar GM, Obregon MJ, del Rey FE. Maternal thyroid hormones early in pregnancy and fetal brain development. Best Pract Res Clin Endocrinol Metab. 2004;18:225-248.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Bernal J, Pekonen F. Ontogenesis of the nuclear 3,5,3-triiodothyronine receptor in the human fetal brain. Endocrinology. 1984;114:677-679.</mixed-citation><mixed-citation xml:lang="en">Bernal J, Pekonen F. Ontogenesis of the nuclear 3,5,3-triiodothyronine receptor in the human fetal brain. Endocrinology. 1984;114:677-679.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Jensovsky J, Ruzicka E, Spackova N, Hejdukova B. Changes of event related potential and cognitive processes in patients with subclinical hypothyroidism after thyroxine treatment. Endocr Regul. 2002;36:115-122.</mixed-citation><mixed-citation xml:lang="en">Jensovsky J, Ruzicka E, Spackova N, Hejdukova B. Changes of event related potential and cognitive processes in patients with subclinical hypothyroidism after thyroxine treatment. Endocr Regul. 2002;36:115-122.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Desouza LA, Ladiwala U, Daniel SM et al. Thyroid hormone regulates hippocampal neurogenesis in the adult rat brain. Mol Cell Neurosci. 2005;29:414-426.</mixed-citation><mixed-citation xml:lang="en">Desouza LA, Ladiwala U, Daniel SM et al. Thyroid hormone regulates hippocampal neurogenesis in the adult rat brain. Mol Cell Neurosci. 2005;29:414-426.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Hetzel BS. Iodine and neuropsychological development. J Nutr. 2000;130(February(2S Suppl.)):493S-495S.</mixed-citation><mixed-citation xml:lang="en">Hetzel BS. Iodine and neuropsychological development. J Nutr. 2000;130(February(2S Suppl.)):493S-495S.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Vulsma T, Gons MH, Devijlder JJM. Maternal fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis. New Engl J Med. 1989;321:13-16.</mixed-citation><mixed-citation xml:lang="en">Vulsma T, Gons MH, Devijlder JJM. Maternal fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis. New Engl J Med. 1989;321:13-16.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">McCarrison R. Observations on endemic cretinism in the Chitral and Gilgit valleys. Lancet. 1908;2:1275-1280.</mixed-citation><mixed-citation xml:lang="en">McCarrison R. Observations on endemic cretinism in the Chitral and Gilgit valleys. Lancet. 1908;2:1275-1280.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Chen ZP, Hetzel BS. Cretinism revisited. Best Pract Res Clin Endocrinol Metab. 2010;24:39-50.</mixed-citation><mixed-citation xml:lang="en">Chen ZP, Hetzel BS. Cretinism revisited. Best Pract Res Clin Endocrinol Metab. 2010;24:39-50.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Pharoah PO, Buttfield IH, Hetzel BS. Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Lancet. 1971;1:308-310.</mixed-citation><mixed-citation xml:lang="en">Pharoah PO, Buttfield IH, Hetzel BS. Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Lancet. 1971;1:308-310.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Pharoah PO, Connolly KJ. A controlled trial of iodinated oil for the prevention of endemic cretinism: a long-term follow-up. Int J Epidemiol. 1987;16:68-73.</mixed-citation><mixed-citation xml:lang="en">Pharoah PO, Connolly KJ. A controlled trial of iodinated oil for the prevention of endemic cretinism: a long-term follow-up. Int J Epidemiol. 1987;16:68-73.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Pharoah PO, Connolly KJ. Effects of maternal iodine supplementation during pregnancy. Arch Dis Child. 1991;66:145-147.</mixed-citation><mixed-citation xml:lang="en">Pharoah PO, Connolly KJ. Effects of maternal iodine supplementation during pregnancy. Arch Dis Child. 1991;66:145-147.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Pharoah P, Buttfield IH, Hetzel BS. Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Int J Epidemiol. 2012 Jun;41(3):589-592.</mixed-citation><mixed-citation xml:lang="en">Pharoah P, Buttfield IH, Hetzel BS. Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Int J Epidemiol. 2012 Jun;41(3):589-592.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Thilly CH, Delange F, Lagasse R et al. Fetal hypothyroidism and maternal thyroid status in severe endemic goiter. J Clin Endocrinol Metab. 1978;47:354-360.</mixed-citation><mixed-citation xml:lang="en">Thilly CH, Delange F, Lagasse R et al. Fetal hypothyroidism and maternal thyroid status in severe endemic goiter. J Clin Endocrinol Metab. 1978;47:354-360.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Moreno-Reyes R, Hindlet JY, Bourdoux P, Vanderpas JB. Maternal, fetal and juvenile hypothyroidism, birthweight and infant mortality in the etiopathogenesis of the IDD spectrum in Zaire and Malawi. In: Stanbury JB, editor. The damaged brain of iodine deficiency cognitive, behavioral, neuromotor, educative aspects. New York: Cognizant Communication Corporation; 1994. p. VII,335 S.</mixed-citation><mixed-citation xml:lang="en">Moreno-Reyes R, Hindlet JY, Bourdoux P, Vanderpas JB. Maternal, fetal and juvenile hypothyroidism, birthweight and infant mortality in the etiopathogenesis of the IDD spectrum in Zaire and Malawi. In: Stanbury JB, editor. The damaged brain of iodine deficiency cognitive, behavioral, neuromotor, educative aspects. New York: Cognizant Communication Corporation; 1994. p. VII,335 S.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Cao XY, Jiang XM, Dou ZH et al. Timing of vulnerability of the brain to iodine deficiency in endemic cretinism. N Engl J Med. 1994;331:1739-1744.</mixed-citation><mixed-citation xml:lang="en">Cao XY, Jiang XM, Dou ZH et al. Timing of vulnerability of the brain to iodine deficiency in endemic cretinism. N Engl J Med. 1994;331:1739-1744.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">O’Donnell KJ, Rakeman MA, Zhi-Hong D et al. Effects of iodine supplementation during pregnancy on child growth and development at school age. Dev Med Child Neurol. 2002;44:76-81.</mixed-citation><mixed-citation xml:lang="en">O’Donnell KJ, Rakeman MA, Zhi-Hong D et al. Effects of iodine supplementation during pregnancy on child growth and development at school age. Dev Med Child Neurol. 2002;44:76-81.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Murcia M, Rebagliato M, Iniguez C et al. Effect of iodine supplementation during pregnancy on infant neurodevelopment at 1 year of age. Am J Epidemiol. 2011 Apr 1;173(7):804-812.</mixed-citation><mixed-citation xml:lang="en">Murcia M, Rebagliato M, Iniguez C et al. Effect of iodine supplementation during pregnancy on infant neurodevelopment at 1 year of age. Am J Epidemiol. 2011 Apr 1;173(7):804-812.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Haddow JE, Palomaki GE, Allan WC et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med. 1999;341:549-555.</mixed-citation><mixed-citation xml:lang="en">Haddow JE, Palomaki GE, Allan WC et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med. 1999;341:549-555.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Pop VJ, Kuijpens JL, van Baar AL et al. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol. 1999;50:149-155.</mixed-citation><mixed-citation xml:lang="en">Pop VJ, Kuijpens JL, van Baar AL et al. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol. 1999;50:149-155.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmermann MB. Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. Am J Clin Nutr. 2009;89:668S-672S.</mixed-citation><mixed-citation xml:lang="en">Zimmermann MB. Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. Am J Clin Nutr. 2009;89:668S-672S.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Chaouki ML, Benmiloud M. Prevention of iodine deficiency disorders by oral administration of lipiodol during pregnancy. Eur J Endocrinol. 1994;130:547-551.</mixed-citation><mixed-citation xml:lang="en">Chaouki ML, Benmiloud M. Prevention of iodine deficiency disorders by oral administration of lipiodol during pregnancy. Eur J Endocrinol. 1994;130:547-551.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Alvarez-Pedrerol M, Guxens M, Mendez M et al. Iodine levels and thyroid hormones in healthy pregnant women and birth weight of their offspring. Eur J Endocrinol. 2009;160(3):423-429.</mixed-citation><mixed-citation xml:lang="en">Alvarez-Pedrerol M, Guxens M, Mendez M et al. Iodine levels and thyroid hormones in healthy pregnant women and birth weight of their offspring. Eur J Endocrinol. 2009;160(3):423-429.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Das SC, Mohammed AZ, Al-Hassan S et al. Effect of environmental iodine deficiency (EID) on foetal growth in Nigeria. Indian J Med Res. 2006;124(5):535-544.</mixed-citation><mixed-citation xml:lang="en">Das SC, Mohammed AZ, Al-Hassan S et al. Effect of environmental iodine deficiency (EID) on foetal growth in Nigeria. Indian J Med Res. 2006;124(5):535-544.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Mason JB, Deitchler M, Gilman A et al. Iodine fortification is related to increased weight-for-age and birthweight in children in Asia. Food Nutr Bull. 2002;23(3):292-308.</mixed-citation><mixed-citation xml:lang="en">Mason JB, Deitchler M, Gilman A et al. Iodine fortification is related to increased weight-for-age and birthweight in children in Asia. Food Nutr Bull. 2002;23(3):292-308.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">DeLong GR, Leslie PW, Wang SH et al. Effect on infant mortality of iodination of irrigation water in a severely iodine-deficient area of China. Lancet. 1997;350:771-773.</mixed-citation><mixed-citation xml:lang="en">DeLong GR, Leslie PW, Wang SH et al. Effect on infant mortality of iodination of irrigation water in a severely iodine-deficient area of China. Lancet. 1997;350:771-773.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Thilly CH, Delange F, Lagasse R et al. Fetal hypothyroidism and maternal thyroid status in severe endemic goiter. J Clin Endocrinol Metab. 1978;47:354-360.</mixed-citation><mixed-citation xml:lang="en">Thilly CH, Delange F, Lagasse R et al. Fetal hypothyroidism and maternal thyroid status in severe endemic goiter. J Clin Endocrinol Metab. 1978;47:354-360.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Cobra C, Muhilal, Rusmil K et al. Infant survival is improved by oral iodine supplementation. J Nutr. 1997;127:574-578.</mixed-citation><mixed-citation xml:lang="en">Cobra C, Muhilal, Rusmil K et al. Infant survival is improved by oral iodine supplementation. J Nutr. 1997;127:574-578.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Semba RD, de Pee S, Hess SY et al. Child malnutrition and mortality among families not utilizing adequately iodized salt in Indonesia. Am J Clin Nutr. 2008;87:438-444.</mixed-citation><mixed-citation xml:lang="en">Semba RD, de Pee S, Hess SY et al. Child malnutrition and mortality among families not utilizing adequately iodized salt in Indonesia. Am J Clin Nutr. 2008;87:438-444.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Azizi F, Kalani H, Kimiagar M et al. Physical, neuromotor and intellectual impairment in non-cretinous schoolchildren with iodine deficiency. Int J Vitam Nutr Res. 1995;65:199-205.</mixed-citation><mixed-citation xml:lang="en">Azizi F, Kalani H, Kimiagar M et al. Physical, neuromotor and intellectual impairment in non-cretinous schoolchildren with iodine deficiency. Int J Vitam Nutr Res. 1995;65:199-205.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Boyages SC, Collins JK, Maberly GF et al. Iodine deficiency impairs intellectual and neuromotor development in apparently normal persons. A study of rural inhabitants of north-central China. Med J Aust. 1989;150:676-682.</mixed-citation><mixed-citation xml:lang="en">Boyages SC, Collins JK, Maberly GF et al. Iodine deficiency impairs intellectual and neuromotor development in apparently normal persons. A study of rural inhabitants of north-central China. Med J Aust. 1989;150:676-682.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Choudhury N, Gorman KS. Subclinical prenatal iodine deficiency negatively affects infant development in Northern China. J Nutr. 2003;133:3162-3165.</mixed-citation><mixed-citation xml:lang="en">Choudhury N, Gorman KS. Subclinical prenatal iodine deficiency negatively affects infant development in Northern China. J Nutr. 2003;133:3162-3165.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Fenzi GF, Giusti LF, Aghini-Lombardi F et al. Neuropsychological assessment in schoolchildren from an area of moderate iodine deficiency. J Endocrinol Invest. 1990;13:427-431.</mixed-citation><mixed-citation xml:lang="en">Fenzi GF, Giusti LF, Aghini-Lombardi F et al. Neuropsychological assessment in schoolchildren from an area of moderate iodine deficiency. J Endocrinol Invest. 1990;13:427-431.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Gao TS, Teng WP, Shan ZY et al. Effect of different iodine intake on schoolchildren’s thyroid diseases and intelligence in rural areas. Chin Med J (Engl). 2004;117:1518-1522.</mixed-citation><mixed-citation xml:lang="en">Gao TS, Teng WP, Shan ZY et al. Effect of different iodine intake on schoolchildren’s thyroid diseases and intelligence in rural areas. Chin Med J (Engl). 2004;117:1518-1522.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Huda SN, Grantham-McGregor SM, Rahman KM, Tomkins A. Biochemical hypothyroidism secondary to iodine deficiency is associated with poor school achievement and cognition in Bangladeshi children. J Nutr. 1999;129:980-997.</mixed-citation><mixed-citation xml:lang="en">Huda SN, Grantham-McGregor SM, Rahman KM, Tomkins A. Biochemical hypothyroidism secondary to iodine deficiency is associated with poor school achievement and cognition in Bangladeshi children. J Nutr. 1999;129:980-997.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Ojule AC, Osotimehin BO. The influence of iodine deficiency on the cognitive performance of school children in Saki, south-west Nigeria. Afr J Med Sci. 1998;27:95-99.</mixed-citation><mixed-citation xml:lang="en">Ojule AC, Osotimehin BO. The influence of iodine deficiency on the cognitive performance of school children in Saki, south-west Nigeria. Afr J Med Sci. 1998;27:95-99.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Vermiglio F, Sidoti M, Finocchiaro MD et al. Defective neuromotor and cognitive-ability in iodine-deficient schoolchildren of an endemic goiter region in Sicily. J Clin Endocr Metab. 1990;70:379-384.</mixed-citation><mixed-citation xml:lang="en">Vermiglio F, Sidoti M, Finocchiaro MD et al. Defective neuromotor and cognitive-ability in iodine-deficient schoolchildren of an endemic goiter region in Sicily. J Clin Endocr Metab. 1990;70:379-384.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Santiago-Fernandez P, Torres-Barahona R, Muela-Martinez JA et al. Intelligence quotient and iodine intake: a cross-sectional study in children. J Clin Endocrinol Metab. 2004;89: 3851-3857.</mixed-citation><mixed-citation xml:lang="en">Santiago-Fernandez P, Torres-Barahona R, Muela-Martinez JA et al. Intelligence quotient and iodine intake: a cross-sectional study in children. J Clin Endocrinol Metab. 2004;89: 3851-3857.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Vermiglio F, Lo Presti VP, Moleti M et al. Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: a possible novel iodine deficiency disorder in developed countries. J Clin Endocrinol Metab. 2004;89:6054-6060.</mixed-citation><mixed-citation xml:lang="en">Vermiglio F, Lo Presti VP, Moleti M et al. Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: a possible novel iodine deficiency disorder in developed countries. J Clin Endocrinol Metab. 2004;89:6054-6060.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Sameroff AJ, Seifer R, Baldwin A, Baldwin C. Stability of intelligence from preschool to adolescence - the influence of social and family risk-factors. Child Dev. 1993;64:80-97.</mixed-citation><mixed-citation xml:lang="en">Sameroff AJ, Seifer R, Baldwin A, Baldwin C. Stability of intelligence from preschool to adolescence - the influence of social and family risk-factors. Child Dev. 1993;64:80-97.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Щеплягина ЛА. Препараты йода в укреплении здоровья детей. Consilium Medicum. Педиатрия. 2010;12(1).</mixed-citation><mixed-citation xml:lang="en">Щеплягина ЛА. Препараты йода в укреплении здоровья детей. Consilium Medicum. Педиатрия. 2010;12(1).</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Bautista A, Barker PA, Dunn JT et al. The effects of oral iodized oil on intelligence, thyroid status, and somatic growth in school-age children from an area of endemic goiter. Am J Clin Nutr. 1982;35:127-134.</mixed-citation><mixed-citation xml:lang="en">Bautista A, Barker PA, Dunn JT et al. The effects of oral iodized oil on intelligence, thyroid status, and somatic growth in school-age children from an area of endemic goiter. Am J Clin Nutr. 1982;35:127-134.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Huda SN, Grantham-McGregor SM, Tomkins A. Cognitive and motor functions of iodine-deficient but euthyroid children in Bangladesh do not benefit from iodized poppy seed oil (Lipiodol). J Nutr. 2001;131:72-77.</mixed-citation><mixed-citation xml:lang="en">Huda SN, Grantham-McGregor SM, Tomkins A. Cognitive and motor functions of iodine-deficient but euthyroid children in Bangladesh do not benefit from iodized poppy seed oil (Lipiodol). J Nutr. 2001;131:72-77.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Isa ZM, Alias IZ, Kadir KA, Ali O. Effect of iodized oil supplementation on thyroid hormone levels and mental performance among Orang Asli schoolchildren and pregnant mothers in an endemic goitre area in Peninsular Malaysia. Asia Pac J Clin Nutr. 2000;9:274-281.</mixed-citation><mixed-citation xml:lang="en">Isa ZM, Alias IZ, Kadir KA, Ali O. Effect of iodized oil supplementation on thyroid hormone levels and mental performance among Orang Asli schoolchildren and pregnant mothers in an endemic goitre area in Peninsular Malaysia. Asia Pac J Clin Nutr. 2000;9:274-281.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Shrestha R. Effect of iodine and iron supplementation on physical, psychomotor and mental development in primary school children in Malawi [doctoral thesis]. Wageningen: Wageningen Agricultural University; 1994.</mixed-citation><mixed-citation xml:lang="en">Shrestha R. Effect of iodine and iron supplementation on physical, psychomotor and mental development in primary school children in Malawi [doctoral thesis]. Wageningen: Wageningen Agricultural University; 1994.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor PN, Okosieme OE, Dayan CM, Lazarus JH. Impact of iodine supplementation in mild-to-moderate iodine deficiency: Systematic review and meta-analysis. Eur J Endocrinol. 2013 Nov 22;170(1):R1-R15.</mixed-citation><mixed-citation xml:lang="en">Taylor PN, Okosieme OE, Dayan CM, Lazarus JH. Impact of iodine supplementation in mild-to-moderate iodine deficiency: Systematic review and meta-analysis. Eur J Endocrinol. 2013 Nov 22;170(1):R1-R15.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Bougma K, Aboud FE, Harding KB, Marquis GS. Iodine and mental development of children 5 years old and under: a systematic review and meta-analysis. Nutrients. 2013 Apr 22;5(4):1384-1416.</mixed-citation><mixed-citation xml:lang="en">Bougma K, Aboud FE, Harding KB, Marquis GS. Iodine and mental development of children 5 years old and under: a systematic review and meta-analysis. Nutrients. 2013 Apr 22;5(4):1384-1416.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmermann MB, Connolly K, Bozo M et al. Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study. Am J Clin Nutr. 2006;83:108-114.</mixed-citation><mixed-citation xml:lang="en">Zimmermann MB, Connolly K, Bozo M et al. Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study. Am J Clin Nutr. 2006;83:108-114.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Gordon RC, Rose MC, Skeaff SA et al. Iodine supplementation improves cognition in mildly iodine-deficient children. Am J Clin Nutr. 2009;90:1264-1271.</mixed-citation><mixed-citation xml:lang="en">Gordon RC, Rose MC, Skeaff SA et al. Iodine supplementation improves cognition in mildly iodine-deficient children. Am J Clin Nutr. 2009;90:1264-1271.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Calza L, Fernandez M, Giardino L. Cellular approaches to central nervous system remyelination stimulation: thyroid hormone to promote myelin repair via endogenous stem and precursor cells. J Mol Endocrinol. 2010;44(1):13-23.</mixed-citation><mixed-citation xml:lang="en">Calza L, Fernandez M, Giardino L. Cellular approaches to central nervous system remyelination stimulation: thyroid hormone to promote myelin repair via endogenous stem and precursor cells. J Mol Endocrinol. 2010;44(1):13-23.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Dussault JH, Ruel J. Thyroid hormones and brain development. Annu Rev Physiol. 1987;49:321-324.</mixed-citation><mixed-citation xml:lang="en">Dussault JH, Ruel J. Thyroid hormones and brain development. Annu Rev Physiol. 1987;49:321-324.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Isaacs E, Oates J. Nutrition and cognition: assessing cognitive abilities in children and young people. Eur J Nutr. 2008;47:4-24.</mixed-citation><mixed-citation xml:lang="en">Isaacs E, Oates J. Nutrition and cognition: assessing cognitive abilities in children and young people. Eur J Nutr. 2008;47:4-24.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Bleichrodt N, Born MP. A metaanalysis of research on iodine and its relationship to cognitive development. In: Stanbury FA, editor. The damaged brain of iodine deficiency cognitive, behavioral, neuromotor, educative aspects. New York [etc.]: Cognizant Communication Corporation; 1994. p. VII, 335 S.</mixed-citation><mixed-citation xml:lang="en">Bleichrodt N, Born MP. A metaanalysis of research on iodine and its relationship to cognitive development. In: Stanbury FA, editor. The damaged brain of iodine deficiency cognitive, behavioral, neuromotor, educative aspects. New York [etc.]: Cognizant Communication Corporation; 1994. p. VII, 335 S.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Qian M, Wang D, Watkins WE et al. The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China. Asia Pac J Clin Nutr. 2005;14:32-42.</mixed-citation><mixed-citation xml:lang="en">Qian M, Wang D, Watkins WE et al. The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China. Asia Pac J Clin Nutr. 2005;14:32-42.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Koutras DA, Christakis G, Trichopoulos D et al. Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and non goitrous populations. Am J Clin Nutr. 1973;26:1360-1368.</mixed-citation><mixed-citation xml:lang="en">Koutras DA, Christakis G, Trichopoulos D et al. Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and non goitrous populations. Am J Clin Nutr. 1973;26:1360-1368.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Bautista A, Barker PA, Dunn JT, Sanchez M. Lack of correlation between thyroid size and body growth in an area of endemic goiter. Am J Clin Nutr. 1977;30:275-279.</mixed-citation><mixed-citation xml:lang="en">Bautista A, Barker PA, Dunn JT, Sanchez M. Lack of correlation between thyroid size and body growth in an area of endemic goiter. Am J Clin Nutr. 1977;30:275-279.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Ali O, Tan TT, Sakinah O, Khalid BA et al. Thyroid function and pubertal development in malnutrition. Ann Acad Med Singapore. 1994;23:852-825.</mixed-citation><mixed-citation xml:lang="en">Ali O, Tan TT, Sakinah O, Khalid BA et al. Thyroid function and pubertal development in malnutrition. Ann Acad Med Singapore. 1994;23:852-825.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Lal RB, Srivastava VK, Chandra R. A study of spectrum of iodine deficiency disorders in rural area of Uttar Pradesh. Indian J Publ Health. 1996;40:10-12.</mixed-citation><mixed-citation xml:lang="en">Lal RB, Srivastava VK, Chandra R. A study of spectrum of iodine deficiency disorders in rural area of Uttar Pradesh. Indian J Publ Health. 1996;40:10-12.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Thurlow RA, Winichagoon P, Pongcharoen T et al. Risk of zinc, iodine and other micronutrient deficiencies among school children in North East Thailand. Eur J Clin Nutr. 2006;60:623-632.</mixed-citation><mixed-citation xml:lang="en">Thurlow RA, Winichagoon P, Pongcharoen T et al. Risk of zinc, iodine and other micronutrient deficiencies among school children in North East Thailand. Eur J Clin Nutr. 2006;60:623-632.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Ren Q, Gr D, Cao X et al. Effect of environmental supplementation of iodine on infant mortality and growth in children in Xinjiang, China. Zhonghua Liu Xing Bing Xue Za Zhi. 2002;23:198-202.</mixed-citation><mixed-citation xml:lang="en">Ren Q, Gr D, Cao X et al. Effect of environmental supplementation of iodine on infant mortality and growth in children in Xinjiang, China. Zhonghua Liu Xing Bing Xue Za Zhi. 2002;23:198-202.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Moreno-Reyes R, Mathieu F, Boelaert M et al. Selenium and iodine supplementation of rural Tibetan children affected by Kashin-Beck osteoarthropathy. Am J Clin Nutr. 2003;78: 137-144.</mixed-citation><mixed-citation xml:lang="en">Moreno-Reyes R, Mathieu F, Boelaert M et al. Selenium and iodine supplementation of rural Tibetan children affected by Kashin-Beck osteoarthropathy. Am J Clin Nutr. 2003;78: 137-144.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Rivera JA, Gonzalez-Cossio T, Flores M et al. Multiple micronutrient supplementation increases the growth of Mexican infants. Am J Clin Nutr. 2001;74:657-663.</mixed-citation><mixed-citation xml:lang="en">Rivera JA, Gonzalez-Cossio T, Flores M et al. Multiple micronutrient supplementation increases the growth of Mexican infants. Am J Clin Nutr. 2001;74:657-663.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">van Stuijvenberg ME, Kvalsvig JD, Faber M et al. Effect of iron-, iodine-, and beta-carotene-fortified biscuits on the micronutrient status of primary school children: a randomized controlled trial. Am J Clin Nutr. 1999;69:497-503.</mixed-citation><mixed-citation xml:lang="en">van Stuijvenberg ME, Kvalsvig JD, Faber M et al. Effect of iron-, iodine-, and beta-carotene-fortified biscuits on the micronutrient status of primary school children: a randomized controlled trial. Am J Clin Nutr. 1999;69:497-503.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Shapiro LE, Samuels HH, Yaffe BM. Thyroid and glucocorticoid hormones synergistically control growth-hormone messenger-Rna in cultured Gh1 cells. Proc Natl Acad Sci USA. 1978;75:45-49.</mixed-citation><mixed-citation xml:lang="en">Shapiro LE, Samuels HH, Yaffe BM. Thyroid and glucocorticoid hormones synergistically control growth-hormone messenger-Rna in cultured Gh1 cells. Proc Natl Acad Sci USA. 1978;75:45-49.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Robson H, Siebler T, Shalet SM, Williams GR. Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth. Pediatr Res. 2002;52:137-147.</mixed-citation><mixed-citation xml:lang="en">Robson H, Siebler T, Shalet SM, Williams GR. Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth. Pediatr Res. 2002;52:137-147.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Shields BM, Knight BA, Hill A et al. Fetal thyroid hormone level at birth is associated with fetal growth. J Clin Endocrinol Metab. 2011;96(6):E934-938.</mixed-citation><mixed-citation xml:lang="en">Shields BM, Knight BA, Hill A et al. Fetal thyroid hormone level at birth is associated with fetal growth. J Clin Endocrinol Metab. 2011;96(6):E934-938.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Ceda GP, Fielder PJ, Donovan SM et al. Regulation of insulin-like growth factor-binding protein expression by thyroid-hormone in rat Gh3 pituitary-tumor cells. Endocrinology. 1992;130:1483- 1489.</mixed-citation><mixed-citation xml:lang="en">Ceda GP, Fielder PJ, Donovan SM et al. Regulation of insulin-like growth factor-binding protein expression by thyroid-hormone in rat Gh3 pituitary-tumor cells. Endocrinology. 1992;130:1483- 1489.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Ezzat S, Laks D, Oster J, Melmed S. Growth-hormone regulation in primary fetal and neonatal rat pituitary cell-cultures - the role of thyroid-hormone. Endocrinology. 1991;128:937-943.</mixed-citation><mixed-citation xml:lang="en">Ezzat S, Laks D, Oster J, Melmed S. Growth-hormone regulation in primary fetal and neonatal rat pituitary cell-cultures - the role of thyroid-hormone. Endocrinology. 1991;128:937-943.</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Samuels MH, Wierman ME, Wang C, Ridgway EC. The effect of altered thyroid status on pituitary-hormone messenger ribonucleic-acid concentrations in the rat. Endocrinology. 1989;124: 2277-2282.</mixed-citation><mixed-citation xml:lang="en">Samuels MH, Wierman ME, Wang C, Ridgway EC. The effect of altered thyroid status on pituitary-hormone messenger ribonucleic-acid concentrations in the rat. Endocrinology. 1989;124: 2277-2282.</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Crew MD, Spindler SR. Thyroid hormone regulation of the transfected rat growth hormone promoter. J Biol Chem. 1986;261:5018- 5022.</mixed-citation><mixed-citation xml:lang="en">Crew MD, Spindler SR. Thyroid hormone regulation of the transfected rat growth hormone promoter. J Biol Chem. 1986;261:5018- 5022.</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Hochberg Z, Bick T, Harel Z. Alterations of human growth-hormone binding by rat-liver membranes during hypothyroidism and hyperthyroidism. Endocrinology. 1990;126:325-329.</mixed-citation><mixed-citation xml:lang="en">Hochberg Z, Bick T, Harel Z. Alterations of human growth-hormone binding by rat-liver membranes during hypothyroidism and hyperthyroidism. Endocrinology. 1990;126:325-329.</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Nilsson A, Ohlsson C, Isaksson OGP et al. Hormonal regulation of longitudinal bone-growth. Eur J Clin Nutr. 1994;48:S150-160.</mixed-citation><mixed-citation xml:lang="en">Nilsson A, Ohlsson C, Isaksson OGP et al. Hormonal regulation of longitudinal bone-growth. Eur J Clin Nutr. 1994;48:S150-160.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Hernandez-Cassis C, Cure-Cure C, Lopez-Jaramillo P. Effect of thyroid replacement therapy on the stature of Colombian children with minimal thyroid dysfunction. Eur J Clin Invest. 1995;25:454- 456.</mixed-citation><mixed-citation xml:lang="en">Hernandez-Cassis C, Cure-Cure C, Lopez-Jaramillo P. Effect of thyroid replacement therapy on the stature of Colombian children with minimal thyroid dysfunction. Eur J Clin Invest. 1995;25:454- 456.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev. 1995;16:3-34.</mixed-citation><mixed-citation xml:lang="en">Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev. 1995;16:3-34.</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Sjogren K, Jansson JO, Isaksson OG, Ohlsson C. A model for tissue-specific inducible insulin-like growth factor-I (IGF-I) inactivation to determine the physiological role of liver-derived IGF-I. Endocrine. 2002;19:249-256.</mixed-citation><mixed-citation xml:lang="en">Sjogren K, Jansson JO, Isaksson OG, Ohlsson C. A model for tissue-specific inducible insulin-like growth factor-I (IGF-I) inactivation to determine the physiological role of liver-derived IGF-I. Endocrine. 2002;19:249-256.</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Ferry RJ, Cerri RW, Cohen P. Insulin-like growth factor binding proteins: new proteins, new functions. Horm Res. 1999;51:53-67.</mixed-citation><mixed-citation xml:lang="en">Ferry RJ, Cerri RW, Cohen P. Insulin-like growth factor binding proteins: new proteins, new functions. Horm Res. 1999;51:53-67.</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Miell JP, Taylor AM, Zini M et al. Effects of hypothyroidism and hyperthyroidism on insulin-like growth-factors (IGFs) and growth hormone-binding and IGF-binding proteins. J Clin Endocr Metab. 1993;76:950-955.</mixed-citation><mixed-citation xml:lang="en">Miell JP, Taylor AM, Zini M et al. Effects of hypothyroidism and hyperthyroidism on insulin-like growth-factors (IGFs) and growth hormone-binding and IGF-binding proteins. J Clin Endocr Metab. 1993;76:950-955.</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Iglesias P, Bayon C, Mendez J et al. Serum insulin-like growth factor type 1, insulin-like growth factor-binding protein-1, and insulin-like growth factor-binding protein-3 concentrations in patients with thyroid dysfunction. Thyroid. 2001;11:1043-1048.</mixed-citation><mixed-citation xml:lang="en">Iglesias P, Bayon C, Mendez J et al. Serum insulin-like growth factor type 1, insulin-like growth factor-binding protein-1, and insulin-like growth factor-binding protein-3 concentrations in patients with thyroid dysfunction. Thyroid. 2001;11:1043-1048.</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">Wan Nazaimoon WM, Osman A, Wu LL, Khalid BA. Effects of iodine deficiency on insulin-like growth factor-I, insulin-like growth factor-binding protein-3 levels and height attainment in malnourished children. Clin Endocrinol (Oxf). 1996;45:79-83.</mixed-citation><mixed-citation xml:lang="en">Wan Nazaimoon WM, Osman A, Wu LL, Khalid BA. Effects of iodine deficiency on insulin-like growth factor-I, insulin-like growth factor-binding protein-3 levels and height attainment in malnourished children. Clin Endocrinol (Oxf). 1996;45:79-83.</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">Aydin K, Bideci A, Kendirci M et al. Insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of children living in an iodine- and selenium-deficient endemic goiter area. Biol Trace Elem Res. 2002;90:25-30.</mixed-citation><mixed-citation xml:lang="en">Aydin K, Bideci A, Kendirci M et al. Insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of children living in an iodine- and selenium-deficient endemic goiter area. Biol Trace Elem Res. 2002;90:25-30.</mixed-citation></citation-alternatives></ref><ref id="cit102"><label>102</label><citation-alternatives><mixed-citation xml:lang="ru">Alikasifoglu A, Ozon A, Yordam N. Serum insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 levels in severe iodine deficiency. Turk J Pediatr. 2002;44:215-218.</mixed-citation><mixed-citation xml:lang="en">Alikasifoglu A, Ozon A, Yordam N. Serum insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 levels in severe iodine deficiency. Turk J Pediatr. 2002;44:215-218.</mixed-citation></citation-alternatives></ref><ref id="cit103"><label>103</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmermann MB, Jooste PL, Mabapa NS et al. Treatment of iodine deficiency in school-age children increases insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations and improves somatic growth. J Clin Endocrinol Metab. 2007;92:437-442.</mixed-citation><mixed-citation xml:lang="en">Zimmermann MB, Jooste PL, Mabapa NS et al. Treatment of iodine deficiency in school-age children increases insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations and improves somatic growth. J Clin Endocrinol Metab. 2007;92:437-442.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
