References

ketendo

Клиническая и экспериментальная тиреоидология

Clinical and experimental thyroidology

1995-54722310-3787

Endocrinology Research Centre

10.14341/ket2015225-32

ketendo-7610

Research Article

Статьи

Articles

Роль таргетной терапии мультикиназными ингибиторами в лечении резистентного к радиойодтерапии дифференцированного рака щитовидной железы

The role of multikinase inhibitors target therapy in radioiodine-resistant differentiated thyroid cancer

Румянцев

Павел Олегович

Rumyantsev

P O

д.м.н., онколог-радиолог, заместитель директора ФГБУ “Эндокринологический научный центр” Минздрава России, Москва, Россия

pavelrum@gmail.com

ФГБУ “Эндокринологический научный центр” Минздрава России, МоскваEndocrinology Research Centre, Moscow, Russian Federation

2015

15062015

112

ТОМ 11, №2 (2015)

2532

2015

Румянцев П.О.

Rumyantsev P.O.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.cet-endojournals.ru/jour/article/view/7610

У 5-15% больных дифференцированным раком щитовидной железы (ДРЩЖ) изначально или в процессе лечения развиваются метастазы, резистентные к терапии радиоактивным йодом, что драматически ухудшает прогноз выживаемости. Другие способы лечения (лучевая терапия, химиотерапия и пр.) также неэффективны. Определенные надежды возлагаются на таргетную терапию мультикиназными ингибиторами, которые селективно блокируют различные онкокиназные молекулярные мишени. В обзоре представлен анализ препаратов этой группы, изучавшихся при радиойодрезистентном ДРЩЖ. Проведен сравнительный анализ эффективности и профиля токсичности двух наиболее перспективных мультикиназных ингибиторов (сорафениб, ленватиниб), успешно прошедших третью фазу клинических исследований и рекомендованных в качестве терапии выбора больным прогрессирующим радиойодрезистентным ДРЩЖ.

About 5-15% of patients with differentiated thyroid cancer (DTC) primary or within follow-up have had distant metastases or inoperable tumor mass that are resistant to radioiodine therapy as well as dramatically deteriorate survival prognosis. Other treatment modalities (radiotherapy, chemotherapy etc.) also ineffective. Certain expectances are associated with target therapy with multikinase inhibitors with are selectively blocking onco-kinase molecular pathways. This review is devoted to analysis of those multikinase inhibitors which have been implemented in patients with radioiodine DTC. Comparative analysis of two most perspective multikinase inhibitors (sorafenib and lenvatinib) with evaluation of efficacy and adverse effects was conducted. Both of them successfully underwent 3 rd phase of clinical trial and were recommended as treatment of choice in progressive radioiodine-resistant DTC patients.

дифференцированный рак щитовидной железырадиойодрезистентностьтаргетная терапиямультикиназные ингибиторысорафенибленватиниб

well-differentiated thyroid cancerradioiodine resistancetarget therapymultikinase inhibitorssorafeniblenvatinib

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The authors declare that there are no conflicts of interest present.