ketendoКлиническая и экспериментальная тиреоидологияClinical and experimental thyroidology1995-54722310-3787Endocrinology Research Centre10.14341/ket2016116-21ketendo-7828Research ArticleОбзоры литературыReview of literatureРоль гормонов щитовидной железы и потребления иода в онтопатогенезе различных заболеваний: акцент на взаимодействиях с глюкокортикоидами и веществами, нарушающими эндокринную регуляциюRole of thyroid hormones and iodine consumption in the ontopathogeny of various diseases: focus on interactions with glucocorticoids and some endocrine disruptorsГудошниковВиктор ИвановичGoudochnikovViktor I.

канд. биол. наук, член Совета Международного общества DOHaD, город Санта-Мария, штат Рио-Гранди-ду-Сул, Бразилия

PhD in Biochemistry, member of the Council, Santa-Maria, Rio-Grandi-du-Sul, Brasil

viktorig@inbox.ruСовет Международного общества DOHaDБразилияCouncil of International Society for DOHaDBrazil2016270520161211621Copyright © Гудошников В.И., 20162016Гудошников В.И.Goudochnikov V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cet-endojournals.ru/jour/article/view/7828

Представлен библиографический мини-обзор об участии гормонов щитовидной железы в явлениях импринтинга/программирования во время перинатального развития во взаимодействии с глюкокортикоидами и некоторыми химическими агентами, загрязняющими окружающую среду и нарушающими эндокринную регуляцию, с увеличением предрасположенности к ряду заболеваний во взрослом состоянии и даже в старости. Кроме того, зарегистрировано недостаточное содержание йода в продаваемых в аптеках лекарственных препаратах с витаминами и микроэлементами для потребления во время беременности и грудного вскармливания, что вносит определенный вклад в более высокий риск субклинического гипотиреоза. Наконец, сделана попытка привлечь внимание к возможному существованию пока еще не идентифицированного метаболического ингибитора, который может нарушать регуляцию функций щитовидной железы при старении.

Bibliographic mini-review is presented on participation of thyroid hormones in programming / imprinting phenomena during perinatal development, as well as on their interactions with glucocorticoids and some environment-polluting endocrine disruptors causing an increase in predisposition to several diseases in adult state and even in senile period. Besides, insufficient content of iodine was registered in pharmaceutical preparations with vitamins and microelements for consumption during gestation and lactation, contributing to higher risk of subclinical hypothyroidism. Finally, an attempt was made to attract more attention to possible existence of unidentified metabolic inhibitor that can interfere in the regulation of thyroid functions in aging.

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The authors declare that there are no conflicts of interest present.