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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ketendo</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая и экспериментальная тиреоидология</journal-title><trans-title-group xml:lang="en"><trans-title>Clinical and experimental thyroidology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5472</issn><issn pub-type="epub">2310-3787</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/ket2016320-24</article-id><article-id custom-type="elpub" pub-id-type="custom">ketendo-8283</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Редакционные материалы</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Editorial note</subject></subj-group></article-categories><title-group><article-title>Прогресс в области профилактики йододефицитных заболеваний в Республике Узбекистан (1998–2016)</article-title><trans-title-group xml:lang="en"><trans-title>Progress in the field of iodine deficiency disorders prevention in Republic of Uzbekistan (1998–2016)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9115-7833</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исмаилов</surname><given-names>Сайдиганиходжа Ибрагимович</given-names></name><name name-style="western" xml:lang="en"><surname>Ismailov</surname><given-names>Said I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><bio xml:lang="en"><p>MD, PhD, Professor</p></bio><email xlink:type="simple">murodrashitov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9208-0455</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рашитов</surname><given-names>Муроджон Мухамеджанович</given-names></name><name name-style="western" xml:lang="en"><surname>Rashitov</surname><given-names>Murodjon M.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>MD, PhD</p></bio><email xlink:type="simple">murodrashitov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Республиканский специализированный научно-практический медицинский центр эндокринологии&#13;
Минздрава Республики Узбекистан</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Republic Specialized Scientific and Practice Medical Center of Endocrinology</institution><country>Uzbekistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>09</day><month>03</month><year>2017</year></pub-date><volume>12</volume><issue>3</issue><fpage>20</fpage><lpage>24</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Исмаилов С.И., Рашитов М.М., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Исмаилов С.И., Рашитов М.М.</copyright-holder><copyright-holder xml:lang="en">Ismailov S.I., Rashitov M.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.cet-endojournals.ru/jour/article/view/8283">https://www.cet-endojournals.ru/jour/article/view/8283</self-uri><abstract><p>Несмотря на проводимые мероприятия, направленные на ликвидацию йододефицитные состояния в стране РУз остается зоной высокой распространенности ЙДЗ. Динамика к снижению йоддефицита была связана с активной работой  по ликвидации йоддефицитных заболевания (ЙДЗ) – это обеспечение йодирующими установками и йодатом калия соледобывающих и солеперерабатывающих предприятий, проведение широкомасштабных санитарно-просветительских мероприятий среди различных слоев населения, государственных предприятий и частного сектора, проведение регулярного мониторинга содержания йода в соли и моче.  В мае 2007 г. был принят закон РУз «О профилактике йододефицитных заболеваний». В настоящей работе приводится анализ йододефицитных состояний в РУз согласно рекомендациям ВОЗ, сентинельным методом.  Согласно данным йодурии нормальные значения йодурии (100-300 мкг/л) наблюдались в 1998 году у 5,6%, в 2016 году у 77% населения. Оптимальный уровень потребления йодированной соли (15,0-55 мкг/г йодата калия) в 1998 году составлял 7,6 % и в 2016 году увеличился до 81 % среди населения.  Распространённость эндемического зоба снизился от 70% в 1998 году до 31% в 2016 году среди населения РУз. Таким образом, отмечается заметное улучшение показателей ЙДЗ по сравнению с предыдущими годами. Однако целевые значения пока не достигнуты. </p></abstract><trans-abstract xml:lang="en"><p>In spite of the works performed against IDD, it still remains severe in Uzbekistan. Progress to lower iodine deficiency was due to the activities to liquidation of iodine deficiency disorders (IDD) including supply with iodizing equipment and supplementation with potassium iodate. The law of Republic of Uzbekistan “Prevention of iodine deficiency disorders” was adopted in May 2007. Current publication demonstrates iodine deficiency level, in accordance with WHO recommendations with sentinel method, in Uzbekistan. It has been revealed that according to ioduria normal values (100–300 mcg/l) of it was 5.6% of population in 1998 year. This value increased up to 77% in 2016 year. Consumption of adequately iodized salt (15,0-55 ppm of potassium iodate) has increased from 7.6% in 1998 till 81% in 2016. Endemic goiter prevalence among population of Uzbekistan decreased from 70% in 1998 till 31% in 2016. Thus, there is notable decrease of iodine deficiency disorders prevalence in Uzbekistan, though target indicators has not been reached yet.</p><p> </p></trans-abstract><kwd-group xml:lang="ru"><kwd>йододефицитные состояния</kwd><kwd>закон</kwd><kwd>Узбекистан</kwd></kwd-group><kwd-group xml:lang="en"><kwd>iodine deficiency disorders</kwd><kwd>law</kwd><kwd>Uzbekistan</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ismailov SI, Rashitov MM, Atadjanova MM, et al. Results of epidemiological studies of prevalence of iodine deficiency disorders in Uzbekistan. Europaische Fachhochschule. 2016;(1):24-27.</mixed-citation><mixed-citation xml:lang="en">Ismailov SI, Rashitov MM, Atadjanova MM, et al. Results of epidemiological studies of prevalence of iodine deficiency disorders in Uzbekistan. Europaische Fachhochschule. 2016;(1):24-27.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ismailov SI, Rashitov MM, Atadjanova MM, et al. Universal salt iodization program in Uzbekistan: A cost-benefit analysis. Europaische Fachhochschule. 2016;(2):21-24.</mixed-citation><mixed-citation xml:lang="en">Ismailov SI, Rashitov MM, Atadjanova MM, et al. Universal salt iodization program in Uzbekistan: A cost-benefit analysis. Europaische Fachhochschule. 2016;(2):21-24.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Всеобщее йодирование соли в государствах Центральной и Восточной Европы и странах СНГ. Опыт, достижения и уроки, приобретенные за 2000-2009 годы. – Женева: ЮНИСЕФ; 2011. [Universal salt iodization in Central and Eastern Europe and the CIS. The experience, achievements and lessons acquired during 2000–2009. Geneva: UNICEF; 2011. (In Russ.)]</mixed-citation><mixed-citation xml:lang="en">Всеобщее йодирование соли в государствах Центральной и Восточной Европы и странах СНГ. Опыт, достижения и уроки, приобретенные за 2000-2009 годы. – Женева: ЮНИСЕФ; 2011. [Universal salt iodization in Central and Eastern Europe and the CIS. The experience, achievements and lessons acquired during 2000–2009. Geneva: UNICEF; 2011. (In Russ.)]</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmermann MB, Burgi H, Hurrell RF. Iron deficiency predicts poor maternal thyroid status during pregnancy. J Clin Endocrinol Metab. 2007;92(9):3436-3440. doi: 10.1210/jc.2007-1082.</mixed-citation><mixed-citation xml:lang="en">Zimmermann MB, Burgi H, Hurrell RF. Iron deficiency predicts poor maternal thyroid status during pregnancy. J Clin Endocrinol Metab. 2007;92(9):3436-3440. doi: 10.1210/jc.2007-1082.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Raileanu I, Diosady LL. Vitamin A stability in salt triple fortified with iodine, iron, and vitamin A. Food Nutr Bull. 2006;27(3):252-259. doi: 10.1177/156482650602700308.</mixed-citation><mixed-citation xml:lang="en">Raileanu I, Diosady LL. Vitamin A stability in salt triple fortified with iodine, iron, and vitamin A. Food Nutr Bull. 2006;27(3):252-259. doi: 10.1177/156482650602700308.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Witzke O, Wiemann J, Patschan D, et al. Differential T4 degradation pathways in young patients with preterminal and terminal renal failure. Horm Metab Res. 2007;39(5):355-358. doi: 10.1055/s-2007-976536.</mixed-citation><mixed-citation xml:lang="en">Witzke O, Wiemann J, Patschan D, et al. Differential T4 degradation pathways in young patients with preterminal and terminal renal failure. Horm Metab Res. 2007;39(5):355-358. doi: 10.1055/s-2007-976536.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ren FL, Guo X, Zhang RJ, et al. Effects of selenium and iodine deficiency on bone, cartilage growth plate and chondrocyte differentiation in two generations of rats. Osteoarthritis Cartilage. 2007;15(10):1171-1177. doi: 10.1016/j.joca.2007.03.013.</mixed-citation><mixed-citation xml:lang="en">Ren FL, Guo X, Zhang RJ, et al. Effects of selenium and iodine deficiency on bone, cartilage growth plate and chondrocyte differentiation in two generations of rats. Osteoarthritis Cartilage. 2007;15(10):1171-1177. doi: 10.1016/j.joca.2007.03.013.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao J, van der Haar F. Progress in salt iodization and improved iodine nutrition in China, 1995-99. Food Nutr Bull. 2004;25(4):337-343. doi: 10.1177/156482650402500403.</mixed-citation><mixed-citation xml:lang="en">Zhao J, van der Haar F. Progress in salt iodization and improved iodine nutrition in China, 1995-99. Food Nutr Bull. 2004;25(4):337-343. doi: 10.1177/156482650402500403.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Pretell EA, Delange F, Hostalek U, et al. Iodine nutrition improves in Latin America. Thyroid. 2004;14(8):590-599. doi: 10.1089/1050725041692909.</mixed-citation><mixed-citation xml:lang="en">Pretell EA, Delange F, Hostalek U, et al. Iodine nutrition improves in Latin America. Thyroid. 2004;14(8):590-599. doi: 10.1089/1050725041692909.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Исмаилов С.И., Нугманова Л.Б., Рашитов М.М., и др. Ситуационный анализ рынка соли по данным предприятий, производящий йодированную соль в Узбекистане // Журнал теоретической и клинической медицины. – 2012. – №6. – С. 16–24. [Ismailov SI, Nugmanova LB, Rashitov MM, et al. Situatsionniy analiz rinka soli po dannim predpriyatiy, proizvodyashih yodirovannuy sol v Uzbekistane. Zhurnal teoreticheskoy i klinicheskoy medicini. 2012;(6):16-24. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Исмаилов С.И., Нугманова Л.Б., Рашитов М.М., и др. Ситуационный анализ рынка соли по данным предприятий, производящий йодированную соль в Узбекистане // Журнал теоретической и клинической медицины. – 2012. – №6. – С. 16–24. [Ismailov SI, Nugmanova LB, Rashitov MM, et al. Situatsionniy analiz rinka soli po dannim predpriyatiy, proizvodyashih yodirovannuy sol v Uzbekistane. Zhurnal teoreticheskoy i klinicheskoy medicini. 2012;(6):16-24. (In Russ.)].</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
