ketendoКлиническая и экспериментальная тиреоидологияClinical and experimental thyroidology1995-54722310-3787Endocrinology Research Centre10.14341/ket9641ketendo-9641Research ArticleОбзоры литературыReview of literatureАутоиммунный полигландулярный синдром взрослых: современные представления о предикторах развития поражения миокарда и диагностике компонентов заболеванияAutoimmune polyglandular syndrome of adults: current ideas about predictors development of damage of a myocardium and diagnostics of components of a diseasehttps://orcid.org/0000-0002-5290-156XПаневинТарас СергеевичPanevinTaras S.

MD

tarasel@list.ruhttps://orcid.org/0000-0001-6265-1210МолашенкоНаталья ВалерьевнаMolashenkoNatalia V.

к.м.н., ведущий научный сотрудник отдела терапевтической эндокринологии

MD, PhD

molashenko@mail.ruhttps://orcid.org/0000-0002-8520-8702ТрошинаЕкатерина АнатольевнаTroshinaEkaterina A.

Заведующая отделом терапевтической эндокринологии, д.м.н., проф. чл.-корр. РАН

MD, PhD, Professor

troshina@inbox.ruhttps://orcid.org/0000-0002-8982-5732ГоловенкоЕлена НиколаевнаGolovenkoElena N.

к.м.н., врач-кардиолог отдела кардиологии и сосудистой хирургии

MD, PhD

Elenagolovenko@gmail.com<p>ФГБУ &ldquo;Национальный медицинский исследовательский центр эндокринологии&rdquo; Минздрава России</p>Россия<p>Endocrinology Research Centre</p>Russian Federation2018230820181429299Copyright &#x00A9; Паневин Т.С., Молашенко Н.В., Трошина Е.А., Головенко Е.Н., 20182018Паневин Т.С., Молашенко Н.В., Трошина Е.А., Головенко Е.Н.Panevin T.S., Molashenko N.V., Troshina E.A., Golovenko E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cet-endojournals.ru/jour/article/view/9641

Аутоиммунный полигландулярный синдром взрослых (АПС) характеризуется поражением двух и более эндокринных желез, приводящим чаще всего к развитию их гормональной недостаточности. Основой большей части аутоиммунных эндокринных заболеваний является лимфоидная и макрофагальная инфильтрация органа-мишени. Зачастую у пациентов с одним аутоиммунным заболеванием другие составляющие АПС проявляются после некоторого латентного периода. Помимо поражения органов эндокринной системы в состав АПС может входить аутоиммунное поражение неэндокринных органов. Хотя поражение сердечно-сосудистой системы не выделено в составе АПС, в некоторых клинических случаях описано развитие поражения миокарда при отсутствии клинически проявляющегося поражения сердца на фоне сочетанной аутоиммунной эндокринной патологии. В обзоре представлены накопленные клинические данные о развитии поражения миокарда на фоне аутоиммунной эндокринной недостаточности, а также лабораторные и инструментальные методы диагностики при данном состоянии. Наиболее перспективными методами диагностики при данном состоянии являются определение аутоантител к компонентам миокарда и магнитно-резонансная томография сердца. В клинической практике возможно широкое использование определения антител к миокарду методом непрямой иммунофлюоресценции, а также с помощью стандартизованных иммуноферментных тест-систем.

The autoimmune polyglandular syndrome of adults (APS) is characterized by the damage of two and more endocrine glands leading more often to development of their hormonal insufficiency. The basis of most autoimmune endocrine diseases is lymphoid and macrophage infiltration of the target organ. Often in patients with one autoimmune disease, other components of the APS appear after a some time of latent period. Besides defeat organs of endocrine system which are including to the APS also not endocrine organs can be part of autoimmune defeat. Although defeat of cardiovascular system is not included in the structure of the APS, in some clinical cases development of damage of a myocardium in the absence of clinically shown damage of heart against the background of the combined autoimmune endocrine pathology is described. The saved-up clinical this development of damage of a myocardium on the background of autoimmune endocrine insufficiency and also laboratory and instrumental methods of diagnostics is presented in the review at this state. The most promising diagnostic methods for this condition are the determination of autoantibodies to myocardial components and magnetic resonance imaging of the heart. In clinical practice, it is possible to widely use the definition of antibodies to myocardium by indirect immunofluorescence, as well as using standardized immunoenzyme test systems.The saved-up clinical this development of damage of a myocardium on the background of autoimmune endocrine insufficiency and also laboratory and instrumental methods of diagnostics is presented in the review at this state.

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The authors declare that there are no conflicts of interest present.