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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ketendo</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая и экспериментальная тиреоидология</journal-title><trans-title-group xml:lang="en"><trans-title>Clinical and experimental thyroidology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5472</issn><issn pub-type="epub">2310-3787</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/ket9777</article-id><article-id custom-type="elpub" pub-id-type="custom">ketendo-9777</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original Studies</subject></subj-group></article-categories><title-group><article-title>Результаты скрининга неонатального ТТГ не совпадают с показателями оптимального йодного статуса у беременных женщин в Республике Грузия</article-title><trans-title-group xml:lang="en"><trans-title>The results of neonatal TSH screening do not agree with indicators of the optimal iodine status of pregnant women in the Republic of Georgia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7107-5905</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Barnabishvilli</surname><given-names>Nelli</given-names></name><name name-style="western" xml:lang="en"><surname>Barnabishvilli</surname><given-names>Nelli</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><bio xml:lang="en"><p>MD, PhD, Professor</p></bio><email xlink:type="simple">nelitest@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6299-7219</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Герасимов</surname><given-names>Григорий Анатольевич</given-names></name><name name-style="western" xml:lang="en"><surname>Gerasimov</surname><given-names>Gregory A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор</p><p> </p></bio><bio xml:lang="en"><p>MD, PhD, Professor</p><p> </p></bio><email xlink:type="simple">gerasimovg@inbox.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Azikuri</surname><given-names>Teimuraz</given-names></name><name name-style="western" xml:lang="en"><surname>Azikuri</surname><given-names>Teimuraz</given-names></name></name-alternatives><bio xml:lang="en"><p>MD</p></bio><email xlink:type="simple">info@exdi.ge</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p&gt;Лаборатория &amp;laquo;Тест Диагностика&amp;raquo;&lt;/p&gt;</institution><country>Грузия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Test Diagnostica Laboratory&lt;/p&gt;</institution><country>Georgia</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>&lt;p&gt;Глобальная сеть по йоду&lt;/p&gt;</institution><country>Соединённые Штаты Америки</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Iodine Global Network (IGN)&lt;/p&gt;</institution><country>United States</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>&lt;p&gt;Лаборатория &amp;laquo;Экспресс Диагностика&amp;raquo;&lt;/p&gt;</institution><country>Грузия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Express Diagnostica Laboratory&lt;/p&gt;</institution><country>Georgia</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>23</day><month>08</month><year>2018</year></pub-date><volume>14</volume><issue>2</issue><fpage>81</fpage><lpage>85</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Barnabishvilli N., Герасимов Г.А., Azikuri T., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Barnabishvilli N., Герасимов Г.А., Azikuri T.</copyright-holder><copyright-holder xml:lang="en">Barnabishvilli N., Gerasimov G.A., Azikuri T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.cet-endojournals.ru/jour/article/view/9777">https://www.cet-endojournals.ru/jour/article/view/9777</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Грузия в прошлом была страной с умеренным и тяжелым дефицитом йода и высокой распространенностью эндемического зоба. Репрезентативное общенациональное обследование, проведенное в Грузии в 2017 г., подтвердило оптимальное обеспечение питания населения йодом с медианной концентрацией йода в моче 298 мкг/л у школьников и 211 мкг/л у беременных женщин.</p></sec><sec><title>Цель</title><p>Цель: оценить статус йодного питания населения Грузии.</p></sec><sec><title>Методы</title><p>Методы. Оценку проводили на основе частоты выявления ТТГ &gt;5 и &gt;20 мМЕ/л у новорожденных, а также путем сопоставления этих данных с результатами прямой оценки йодного статуса, выполненной в ходе национального обследования 2017 г.</p></sec><sec><title>Методы</title><p>Методы. С 2009 по 2015 г. доля новорожденных с ТТГ &gt;20 мМЕ/л уменьшилась в три раза: с 0,45 до 0,15%. Эта тенденция наблюдалась во всех регионах страны с существенным различием между столицей, западной и восточной частями страны. Частота случаев обнаружения концентрации ТТГ &gt;5 мМЕ/л у новорожденных в Грузии уменьшилась с 4,46% в 2009 г. до 3,5% в 2015 г. Однако только в Тбилиси частота обнаружения концентрации ТТГ &gt;5 мМЕ/л у новорожденных была ниже 3% – уровня отсечения для адекватного питания йодом. В других регионах страны (Западная и Восточная Грузия) частота случаев выявления концентрации ТТГ &gt;5 мМЕ/л у новорожденных составляла 3,8 и 4,4% соответственно, что можно было бы ложно интерпретировать как умеренный дефицит йода.</p></sec><sec><title>Заключение</title><p>Заключение. Хотя неонатальный скрининг (определение концентрации ТТГ) полезен для выявления умеренной и тяжелой степени дефицита йода, его следует с осторожностью рекомендовать для оценки в регионах с оптимальным йодным обеспечением и при легком йодном дефиците.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Georgia historically was a country with moderate to severe iodine deficiency and high prevalence of endemic goiter. A representative countrywide iodine survey conducted in Georgia in 2017 confirmed optimal iodine nutrition of the population with median UIC 298 mcg/L in SAC and 211 mcg/L in PW.</p></sec><sec><title>Aim</title><p>Aim. The aim of this study was to assess status of iodine nutrition of population in Georgia.</p></sec><sec><title>Methods</title><p>Methods. The assesement based on the proportion of neonatal Thyroid-Stimulating Hormone (TSH) levels &gt;5mIU/L from 2009 to 2015 and compare these data with the results of direct assessment of iodine status made during the 2017 national survey.</p></sec><sec><title>Results</title><p>Results. From 2009 to 2015 the proportion of newborns with TSH &gt;20 mIU/L decreased threefold: from 0.45 to 0.15%. This trend was observed in all regions of the country with significant difference between the capital city and Western in Eastern parts of the country. There has been also significant reduction of the prevalence of TSH &gt;5 mIU/L in Georgia from 4.46% in 2009 to 3.5% in 2015. However, only in Tbilisi the frequency of elevated TSH was below 3% – the cutoff level for adequate iodine nutrition. In other regions (Western and Eastern Georgia) prevalence of TSH &gt;5 mIU/L was 3.8% and 4.4% respectively that could be falsely interpreted as mild iodine deficiency.</p></sec><sec><title>Conclusions</title><p>Conclusions. Although neonatal TSH is useful to detect moderate to severe iodine deficiency, it should be cautiously recommended for the evaluation of iodine status in iodine sufficient to mildly iodine deficient regions.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>йод</kwd><kwd>неонатальный ТТГ</kwd><kwd>дети школьного возраста</kwd><kwd>беременные женщины</kwd><kwd>Грузия</kwd><kwd>Тбилиси</kwd><kwd>Глобальная сеть по йоду.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>iodine</kwd><kwd>neonatal TSH</kwd><kwd>school-aged children</kwd><kwd>pregnant women</kwd><kwd>Republic of Georgia</kwd><kwd>Tbilisi</kwd><kwd>Iodine Global Network</kwd></kwd-group><funding-group><funding-statement xml:lang="en">Iodine Global Network</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Suchdev PS, Jashi M, Sekhniashvili Z, Woodruff BA. 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