Liquid levothyroxine: questions and answers
https://doi.org/10.14341/ket12818
Abstract
Levothyroxine (L-T4) is a drug with a narrow therapeutic range. Even a small change in the dose can lead to its deficiency or overdose. Existing tablet forms of L-T4 with a wide range of dosages ensure the achievement and maintenance of euthyroidism in many patients. At the same time, patients with hypothyroidism are often decompensated. Today, not only tablets are used in the world, but also other forms of L-T4, including gel capsules and liquid form. The presented review discusses the pharmacokinetics, advantages and disadvantages of the different forms of L-T4. Factors affecting the bioavailability of L-T4 drugs are also discussed.
About the Authors
T. B. Morgunova
https://sechenov.ru/univers/about_lecturer/4055/
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests:
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Tatyana B. Morgunova, MD, Cand. Sci. (Med.)
8 Trubetskaya str., build. 2, 119048, Moscow
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи.
E. G. Ryzhkova
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests:
Russian Federation
Ekaterina G. Ryzhkova, MD, posrgraduate student
Moscow
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи.
A. P. Galkina
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests:
Russian Federation
Anna P. Galkina, MD
Moscow
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи.
V. V. Fadeev
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests:
Russian Federation
Valentin V. Fadeev, MD, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences
Moscow
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи.
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Review
For citations:
Morgunova T.B., Ryzhkova E.G., Galkina A.P., Fadeev V.V. Liquid levothyroxine: questions and answers. Clinical and experimental thyroidology. 2024;20(4):15-19. (In Russ.) https://doi.org/10.14341/ket12818
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