The рopulation сomposition of lymphocyte and the rate of infection by by the herpes simplex virus in patients ill with autoimmune autoimmune thyroiditis

Abstract

The objective of the research is the analysis of blood lymphocyte composition and the rate of infection by the herpes simplex virus (HSV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in patients with AIT. Two men and twenty six women (with the average age 44.0 ± 2.3 years) ill with the disease for 6.0 ± 2.7 years were examined. 85.7% of the ill were in the euthyroid state, 14.3% were in hypothyroidism. 25% ofthe patients were diagnosed with atrophic AIT, 60,7% got the diagnoses of fibroid and fibronodular AIT and 14.3% got hypertrophic AIT diagnoses. It was found that the course of AIT was accompanied with the increase of the rate of CD20 +-lymphocytes in blood at the normal number of CD3 +-, CD4 +-, CD8 +- и CD56 + cells. The IgG to the HSV was found in 92.9% patients with AIT, to the CMV - in 96.4% cases, to the pre-early antigen (ЕА) of CMV (acute infection) - in 39.3% patients and to the nuclear antigen of EBV (КА) (late past-infection) - in 67.6% cases. In two cases we found EBV-IgG to EA and КА simultaneously (late stage of primary EBV-infection or reactivation of its chronic form). It was proved that 39.3% of the patients with AIT associate this disease with acute cytomegalovirus infection.