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Clinical and experimental thyroidology

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Metabolic and hemostatic parameters in patients with type 2 diabetes and hypothyroidism

https://doi.org/10.14341/ket20117362-66

Abstract

To identify hemostatic and metabolic abnormalities in patients with hypothyroidism of varying severity and duration and possible modifying effects of chronic hyperglycemia on the investigated parameters comprehensive analysis of the parameters of metabolism, platelet and plasma hemostasis in 69 patients with hypothyroidism and 36 patients having hypothyroidism and diabetes mellitus (DM) has been performed. Decompensated hypothyroidism regardless of disease duration and presence of complications is accompanied by platelets hyperfunction. In subcompensated hypothyroidism the aggregation activity was not changed. The combination of type 2 diabetes in patients with decompensated and subcompensated hypothyroidism is accompanied by platelets activation, hypertriglyceridemia, increased platelets average volume and shortening of APTT.

About the Author

G Petrik

kand. med. nauk, dotsent kafedry terapii №1 FPK i PPS Kubanskogo gosudarstvennogo meditsinskogo universiteta


References

1. Алгоритмы специализированной медицинской помощи больным сахарным диабетом (Издание четвертое) / Под. ред. И.И.Дедова, М.В. Шестаковой, М., 2009.

2. Folsom A., Wu K., Rasumussen M. Determinants of population changes in fibrinogen and factor VII over 6 year.//Arteriosclerosis, Trombosis and Vasculare Biology. 2000. N20. P. 601–606.

3. Lee H.Y., See T.T., Lee S.P. et al. ADP-Induced Platelet Aggregation in Hypothyroid and Normal Subjects // J. Med. Sci. 1998. V. 18. N5. P. 321–325.

4. Perros P., McCrimmon R.J., Shaw G., Frier B.M. Frequency of Thyroid Dysfunction in Diabetic Patients: Value of Annual Screening. //Diabetic Medicine. 2009. V. 12. N7. P. 622.

5. Schneider D.J. Factors Contributing to Increased Platelet Reactivity in People With Diabetes // Diabetes Care. 2009. V. 32. P. 525–527.

6. Tschoepe D. The activation megacariocyte-platelet-system in vascular disease: focus on diabetes.// Semin. Thromb. Hemost. 1995. V. 21. P. 152–160.


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For citations:


  Metabolic and hemostatic parameters in patients with type 2 diabetes and hypothyroidism. Clinical and experimental thyroidology. 2011;7(3):62-66. (In Russ.) https://doi.org/10.14341/ket20117362-66

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ISSN 1995-5472 (Print)
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