Family History of Autoimmune Thyroid Disease
https://doi.org/10.14341/ket20139439-45
Abstract
The aim of this study was estimate the clinical characteristics of Graves' disease (GD) and Hashimoto's thyroiditis (HT) in first@degree relatives of persons in families with autoimmune thyroid diseases (AITD). Patients: Eighty one patients with AITD of 40 families, mean age (+/@s.d.) 41.9 ± 1.8; range 18-73 years. In 10 families (25%) AITD traced among siblings, whose average age was 33.6 ± 3.5 years, 29 families (72.5%) - of two generations (parent@ descendant) 57.4 ± 1.6 and 32.2 ± 1.5 years, p = 0.001, respectively. In one family (2.5%) the disease was traced in both parents and their offspring. Results. Among patients with a positive family history for AITD is dominated by a pair of parent - descendant with a diagnosis of hypothyroidism (55%). Preliminary evidence of genetic anticipation in GD and HT. Patients with a family history of AITD ill of GD and HT to 50 years (84%), half - up to 30 years (47%). In familial forms of GD, a decrease in compensated patients for two generations. Among parents and descendant with hypothyroidism, there is a low percentage of persons over the medical euthyroidism (42%).
About the Authors
O Rymardoktor med. nauk, vedushchiy nauchnyy sotrudnik laboratorii kliniko-populyatsionnykh i profilakticheskikh issledovaniy terapevticheskikh i endokrinnykh zabolevaniy FGBU “NII terapii” SO RAMN
A Pyankova
zaochnyy aspirant FGBU “NII terapii” SO RAMN
V Maksimov
doktor med. nauk, zav. laboratoriey molekulyarno-geneticheskikh issledovaniy terapevticheskikh zabolevaniy FGBU “NII terapii” SO RAMN
S Mustafina
kand. med. nauk, starshiy nauchnyy sotrudnik laboratorii kliniko-populyatsionnykh i profilakticheskikh issledovaniy terapevticheskikh i endokrinnykh zabolevaniy FGBU “NII terapii” SO RAMN
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Review
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, , , Family History of Autoimmune Thyroid Disease. Clinical and experimental thyroidology. 2013;9(4):39-45. (In Russ.) https://doi.org/10.14341/ket20139439-45
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