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Effect of satiety on TSH and free thyroxin levels in healthy individuals and patients with subclinical and overt hypothyroidism

https://doi.org/10.14341/ket12691

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Аннотация

Background: Thyroid stimulating hormone (TSH) and thyroxine levels may change according to fasting — satiety status. AIM: The aim of this study was to determine the effect of satiety on TSH and free thyroxine levels.

Methods: This study was conducted in a tertiary hospital. According to previous TSH and thyroxine levels, groups of 30, 30 and 60 participants were designated as subclinical hypothyroidism, hypothyroidism, and control groups respectively. To obtain TSH and thyroxine results first phlebotomy was performed at 8 am while participants were in fasting state. Then participants were allowed to have non-standardized breakfast. Second phlebotomy was performed at 10 am while participants were in non-fasting state. Paired t-test and ANOVA were used to analyze the data.

Results: The fasting TSH levels of the participants (2.57 ± 1.84 mlU/L) were significantly higher than the satiety TSH levels (2.04 ± 1.48 mlU/L) (t = 8.566, p < 0.001, d = 0.80). The fasting free thyroxine values (1.31 ± 0.38 mg/dl) of the participants were significantly lower than the satiety free thyroxine values (1.39 ± 0.35 mg/dl) (t = -1.988, p = 0.049, d = 0.20).

Conclusion: Knowing how TSH and free thyroxine tests are affected by satiety has the power to affect treatment of many patients. Our study has shown that both TSH and free thyroxine levels changed significantly according to satiety status.

Об авторах

Mehmet G. Kilingarslan
Çanakkale Onsekiz Mart University
Турция

MD, Dr., Head Physician, Aslanapa State Hospital, Aslanapa İlçe Devlet Hastanesi Hürriyet Mahallesi Şeker Caddesi No:8.

43210 Aslanapa/Kütahya/TURKEY+905066108540


Конфликт интересов:

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Cihan Çelik
Çanakkale Onsekiz Mart University
Турция

MD, Dr., Family Physician, Hakkari Family MC.

30000 Merkez/Hakkari/TURKEY, +905065127378


Конфликт интересов:

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Mehmet Göktuğ Kilinçarslan
Çanakkale Onsekiz Mart University
Турция

Professor, Head of the Department, Department of Family Medicine-Canakkale Onsekiz Mart University, Canakkale Onsekiz Mart Üniversitesi Tıp Fakültesi Aile Hekimliği Anabilim Dalı.

17100 Merkez/Canakkale/TURKEY, +905053026571


Конфликт интересов:

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Для цитирования:


Kilingarslan M.G., Çelik C., Kilinçarslan M.G. Effect of satiety on TSH and free thyroxin levels in healthy individuals and patients with subclinical and overt hypothyroidism. Клиническая и экспериментальная тиреоидология. 2020;16(4):28-32. https://doi.org/10.14341/ket12691

For citation:


Kılınçarslan M.G., Çelik C., Şahin E.M. Effect of satiety on TSH and free thyroxin levels in healthy individuals and patients with subclinical and overt hypothyroidism. Clinical and experimental thyroidology. 2020;16(4):28-32. https://doi.org/10.14341/ket12691

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ISSN 1995-5472 (Print)
ISSN 2310-3787 (Online)