Клиническая и экспериментальная тиреоидология

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Effect of satiety on TSH and free thyroxin levels in healthy individuals and patients with subclinical and overt hypothyroidism

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Background: Thyroid stimulating hormone (TSH) and thyroxine levels may change according to fasting — satiety status. AIM: The aim of this study was to determine the effect of satiety on TSH and free thyroxine levels.

Methods: This study was conducted in a tertiary hospital. According to previous TSH and thyroxine levels, groups of 30, 30 and 60 participants were designated as subclinical hypothyroidism, hypothyroidism, and control groups respectively. To obtain TSH and thyroxine results first phlebotomy was performed at 8 am while participants were in fasting state. Then participants were allowed to have non-standardized breakfast. Second phlebotomy was performed at 10 am while participants were in non-fasting state. Paired t-test and ANOVA were used to analyze the data.

Results: The fasting TSH levels of the participants (2.57 ± 1.84 mlU/L) were significantly higher than the satiety TSH levels (2.04 ± 1.48 mlU/L) (t = 8.566, p < 0.001, d = 0.80). The fasting free thyroxine values (1.31 ± 0.38 mg/dl) of the participants were significantly lower than the satiety free thyroxine values (1.39 ± 0.35 mg/dl) (t = -1.988, p = 0.049, d = 0.20).

Conclusion: Knowing how TSH and free thyroxine tests are affected by satiety has the power to affect treatment of many patients. Our study has shown that both TSH and free thyroxine levels changed significantly according to satiety status.

Об авторах

Mehmet G. Kilingarslan
Çanakkale Onsekiz Mart University

MD, Dr., Head Physician, Aslanapa State Hospital, Aslanapa İlçe Devlet Hastanesi Hürriyet Mahallesi Şeker Caddesi No:8.

43210 Aslanapa/Kütahya/TURKEY+905066108540

Конфликт интересов:


Cihan Çelik
Çanakkale Onsekiz Mart University

MD, Dr., Family Physician, Hakkari Family MC.

30000 Merkez/Hakkari/TURKEY, +905065127378

Конфликт интересов:


Mehmet Göktuğ Kilinçarslan
Çanakkale Onsekiz Mart University

Professor, Head of the Department, Department of Family Medicine-Canakkale Onsekiz Mart University, Canakkale Onsekiz Mart Üniversitesi Tıp Fakültesi Aile Hekimliği Anabilim Dalı.

17100 Merkez/Canakkale/TURKEY, +905053026571

Конфликт интересов:


Список литературы

1. Spencer CA. Assay of Thyroid Hormones and Related Substances. In: Feingold KR, Anawalt B, Boyce A, et al., eds. Endotext. South Dartmouth (MA):, Inc.; February 20, 2017. Accessed January 13, 2020.

2. Barrett KE, Barman SM, Boitano S, Brooks HL. Ganong’s review of medical physiology. 25th ed. McGraw-Hill Education; 2015.

3. Hall JE. Guyton and hall textbook of medical physiology E-Book. Elsevier Health Sciences; 2015.

4. Kasper DL, Fauci AS, Hauser SL, et al. Harrison’s principles of internal medicine, (Vol. 1 & Vol. 2). McGraw Hill Professional; 2018.

5. Cahoreau C, Klett D, Combarnous Y. Structure-function relationships of glycoprotein hormones and their subunits’ ancestors. Front Endocrinol (Lausanne). 2015;6:26. Published 2015 Feb 26. doi:

6. Nair R, Mahadevan S, Muralidharan RS, Madhavan S. Does fasting or postprandial state affect thyroid function testing?. Indian J Endocrinol Metab. 2014;18(5):705-707. doi:

7. Mirjanic-Azaric B, Stojakovic-Jelisavac T, Vukovic B, et al. The impact of time of sample collection on the measurement of thyroid stimulating hormone values in the serum. Clin Biochem. 2015;48(18):1347-1349. doi:

8. Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175-191. doi:

9. Field AP. Discovering statistics using IBM SPSS Statistics. 5th ed. SAGE Publications; 2017.

10. Scobbo RR, VonDohlen TW, Hassan M, Islam S. Serum TSH variability in normal individuals: the influence of time of sample collection. W V Med J. 2004;100(4):138-142.

11. Kamat V, Hecht WL, Rubin RT. Influence of meal composition on the postprandial response of the pituitary-thyroid axis. Eur J Endocrinol. 1995;133(1):75-79. doi:

12. Shibasaki T, Masuda A, Hotta M, et al. Effect of ingestion of glucose on GH and TSH secretion: Evidence for stimulation of somatostatin release from the hypothalamus by acute hyperglycemia in normal man and its impairment in acromegalic patients. Life Sci. 1989;44(6):431-438. doi:

13. Tuhanioğlu B, Erkan SO, Özdaş T, et al. Effects of fasting and satiety on thyroid hormone values. KBB-Forum. 2018;17(2):62-67. Accessed January 11, 2020.

14. Patel VI, Akshay BK. A comparative study on outcomes of preprandial versus postprandial thyroid function test. Int J Otorhinolaryngol Head Neck Surg. 2019;5(6):1662. doi:

15. Pradeep TS, Varma S, Tirupati S, et al. Postprandial decline in thyroid-stimulating hormone is significant but not its correlation with postprandial change in plasma glucose. Thyroid Res Pract. 2018;15(3):113. doi:

16. Mahadevan S, Sadacharan D, Kannan S, Suryanarayanan A. Does time of sampling or food intake alter thyroid function test? Indian J Endocrinol Metab. 2017;21(3):369-372. doi:

17. Shivaprasad KS, Chaitra DY, Mohan R. The effect of prandial state on thyrotropin levels in pregnancy. In: 2017 AACE Annual Scientific & Clinical Congress. Vol 23. ; 2017:252-253. doi:

18. Varadarajan P, Kaliyan A, Sankaran SK, et al. Does fasting and postprandial blood sampling for thyroid evaluation make a difference in children? J Evol Med Dent Sci. 2017;6:1515+.

Дополнительные файлы


Для цитирования:

Kilingarslan M.G., Çelik C., Kilinçarslan M.G. Effect of satiety on TSH and free thyroxin levels in healthy individuals and patients with subclinical and overt hypothyroidism. Клиническая и экспериментальная тиреоидология. 2020;16(4):28-32.

For citation:

Kılınçarslan M.G., Çelik C., Şahin E.M. Effect of satiety on TSH and free thyroxin levels in healthy individuals and patients with subclinical and overt hypothyroidism. Clinical and experimental thyroidology. 2020;16(4):28-32.

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ISSN 1995-5472 (Print)
ISSN 2310-3787 (Online)