Macro-TSH in patients with primary hypothyroidism due to autoimmune thyroiditis
A. G. Saribekian,
D. A. Petrenko,
D. A. Trukhina,
A. G. Kuzmin,
L. K. Dzeranova,
L. V. Nikankina,
G. S. Kolesnikova https://doi.org/10.14341/ket12710
Abstract
Thyroid stimulating hormone (TSH) is one of the key indicators in the diagnosis of the thyroid gland functional disorders. Minor changes in TSH concentration make it possible to suspect thyroid dysfunction even before clinical manifestations, which increases the value of correct and timely measurement of it. In the clinical practice, an endocrinologist often encounter the well-known phenomenon of macroprolactinemia; a much less common phenomenon is macrotyrotropinemia (macro-TSH). The presence of macro-TSH complexes can be suspected when the serum detects atypically high TSH values with reference values of FT4 without any signs of hypothyroidism. Since the phenomenon is based on an autoimmune mechanism, macro-TSH can often be detected in patients with autoimmune thyroiditis (AIT). This article presents clinical cases of patients with a combination of the macro-TSH phenomenon and primary hypothyroidism due to AIT.
About the Authors
A. G. Saribekian
Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Anna G. Saribekian, student
Moscow
eLibrary SPIN: 7206-6210
D. A. Petrenko
Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Daria A. Petrenko, student
Moscow
D. A. Trukhina
Endocrinology Research Centre
Russian Federation
Russian Federation
Diana A. Trukhina, MD
Moscow
eLibrary SPIN: 5618-8971
A. G. Kuzmin
Endocrinology Research Centre
Russian Federation
Russian Federation
Anatoly G. Kuzmin, MD, PhD
Moscow
eLibrary SPIN: 7804-2128
L. K. Dzeranova
Endocrinology Research Centre
Russian Federation
Russian Federation
Larisa K. Dzeranova, MD, PhD
Moscow
eLibrary SPIN: 2958-5555
L. V. Nikankina
Endocrinology Research Centre
Russian Federation
Russian Federation
Larisa V. Nikankina, MD, PhD
Moscow
eLibrary SPIN: 2794-0008
G. S. Kolesnikova
Endocrinology Research Centre
Russian Federation
Russian Federation
Galina S. Kolesnikova, PhD
Moscow
eLibrary SPIN: 7716- 9680
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Saribekian A.G., Petrenko D.A., Trukhina D.A., Kuzmin A.G., Dzeranova L.K., Nikankina L.V., Kolesnikova G.S. Macro-TSH in patients with primary hypothyroidism due to autoimmune thyroiditis. Clinical and experimental thyroidology. 2021;17(4):17-20. (In Russ.) https://doi.org/10.14341/ket12710
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