Infringement of cytokines regulation and morphological changes of thyroid gland in Wistar rats with experimental thyrotoxicosis
https://doi.org/10.14341/ket20128239-42
Abstract
In view of abundance of autoimmune diseases of thyroid gland, Graves’ Disease in particular, the role of immune regulation and the possibility of controlling it by estimating the function of regulatory T-limphocytes are important questions today. Available for practical estimation of T- and B-lymphocytes tolerance disorder in GBD are serum levels of Th1- and Th2- marker cytokines. Experimental thyrotoxicosis in Wistar rats showed significant increase in serum Il-1α, IFN-γ and Il-10 depending on the increase of thyroid hormones, as well as significant changes in correlation between pro- and anti-inflammatory cytokines with the shift towards Th1-marker cytokines in supernatant thyroid glands of the animals with thyrotoxicosis. Are found out also changes of proliferative activity thyrocytes with change of average diameter of follicles of a thyroid gland.
About the Authors
V Zdorkand. med. nauk, vrach-endokrinolog, assistent kafedry patofiziologii GBOU VPO Vladivostokskiy gosudarst- vennyy meditsinskiy universitet Minzdravsotsrazvitiya RF
E Markelova
doktor med. nauk, professor, zav. kafedroy patofiziologii GBOU VPO Vladivostokskiy gosudarstvennyy meditsinskiy universitet Minzdravsotsrazvitiya RF, vrach-immunolog
O Oleksenko
kand. med. nauk, dotsent ka- fedry patologicheskoy anatomii GBOU VPO Vladivostokskiy gosudarstvennyy meditsinskiy universitet Minzdravsotsrazvitiya RF
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Review
For citations:
, , Infringement of cytokines regulation and morphological changes of thyroid gland in Wistar rats with experimental thyrotoxicosis. Clinical and experimental thyroidology. 2012;8(2):39-42. (In Russ.) https://doi.org/10.14341/ket20128239-42
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