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Thyrotropin-producing adenoma: diagnostic challenges (Сase report)

https://doi.org/10.14341/ket20117268-73

Abstract

Pituitary thyrotropin-producing adenomas (TSH-omas) are rare tumors that cause hyperthyroidism. Failure to recognize this disease may result in dramatic consequences, such as improper thyroid ablation in patients with central hyperthyroidism. This article concerns the current issues of pathogenesis, diagnostics, differential diagnostics and treatment of TSH-omas. It also describes a case study of a young woman with thyrotropin-producing adenoma.

About the Authors

E Prgijalkovskaja

kand. med. nauk, nauchnyy sotrudnik otdeleniya neyroendokrinologii i osteopatiy FGU Endokrinologicheskiy nauchnyy tsentr Minzdravsotsrazvitiya RF


D Gasisova

aspirant FGU Endokrinologicheskiy nauchnyy tsentr Minzdravsotsrazvitiya RF


A Grigoriev

kand. med. nauk, zaveduyushchiy otdeleniem neyrokhirurgii FGU Endokrinologicheskiy nauchnyy tsentr Minzdravsotsrazvitiya RF


I Voronkova

aspirant FGU Endokrinologicheskiy nauchnyy tsentr Minzdravsotsrazvitiya RF


A Tyulpakov

doktor med. nauk, zaveduyushchiy otdeleniem nasledstvennykh endokrinopatiy FGU Endokrinologicheskiy nauchnyy tsentr Minzdravsotsrazvitiya RF


L Rochinskaja

doktor med. nauk, zaveduyushchaya otdeleniem neyroendokrinologii i osteopatiy FGU Endokrinologicheskiy nauchnyy tsentr Minzdravsotsrazvitiya RF


References

1. Кадашев Б.А., Астафьева Л.И. Аденомы гипофиза. Тверь, 2007. С. 152–155.

2. Ando S., Sarlis N.J., Krishan J. et al. Abberant alternative splicing of thy-roid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance // Mol. Endocr. 2001. V. 15. P. 1529.

3. Ando S., Sarlis N.J., Oldfield E.H., Yen P.M. Somatic mutation of TRbeta can cause a defect in negative regulation of TSH in a TSH-secreting pituitary tumor // J. Clin. Endocr. Met. 2001. V. 86. P. 5572.

4. Baur A., Buchfelder M., Kohrle J. Expression of 5'-deiodinase enzymes in normal pituitaries and in various human pituitary adenomas // Eur. J. Endocr. 2002. V. 147. P. 263.

5. Beck-Peccos P., Brueker-Davis F., Persani L. et al. Thyrotropin-secreting pituitary tumors // Endocr. Rev. 1996. V. 17. P. 610.

6. Beck-Peccoz P., Persani L. TSH-induced hyperthyroidism caused by a pituitary tumor. Nat.Clin. Pract. Endocrinol. Metab. 2006. V.2 (9). P. 524–528.

7. Beck-Peccos P., Roncoroni R., Mariotti S. et al. Sex hormone-binding globulin measurement in patients with inappropriate secretion of thyrotropin (1ST): evidence against selective pituitary thyroid hormone resistance in non-neoplastic 1ST // J. Clin. Endocr. Met. 1990. V. 71. P. 19.

8. Chanson P., Weintraub B.D., Harris A.G. Octreotide therapy for thyroid stimulating hormone-secreting pituitary adenomas: A follow up of 52 patients // Ann. Intern. Med. 1993. V. 119. P. 236.

9. Chatterjee V.K.K., Clifton-Bright R.J., Gurnell M. Thyroid hormone resistance. In: Jameson JL, ed: Contemporary Endocrinology: Hormone Resistance Syndromes. Totowa. Humana Press, 1999. Р. 145–153

10. Dong Q., Brucker-Davis F., Weintraub B.D. et al. Screening of candidate oncogenes in human thyrotropin tumors: absence of activating mutations of the Gall, Gas, or thyrotropin-releasing hormone receptor genes // J. Clin. Endocr. Met. 1996. V. 81. P. 1134.

11. Gesundheit N., Petrick P., Nissim M. et al. Thyrotropin-secreting pituitary adenomas: clinical and biochemical heterogeneity // An. Intern. Med. 1989. V. 111. P. 827.

12. Ghannam N.N., Hammami M.M., Muttair Z. et al. Primary hypothyroidism – associated TSH-secreting pituitary adenoma/hyperplasia presenting as a bleed-ing nasal mass and extremely elevated TSH level // J. Endocr. Invest. 1999. V. 22. P. 419.

13. Hamilton C., Adams L.C., Maloof F. Hyperthyroidism due to thyrotropin-producing pituitary chromophobe adenoma // N. Engl. J. Med. 1970. V. 283. P. 1077.

14. Jailer J.W., Holub D.A. Remission of Graves' disease following radiother-apy of a pituitary neoplasm // Am. J. Med. 1960. V. 28. P. 497.

15. Losa M., Magnani P., Mortini P. et al. Indium-Ill pentetreotide single-photon emission tomography in patients with TSH-secreting pituitary adenomas: correlation with the effect of a single administration of octreotide on cerum TSH levels // Eur. J. Nucl. Med. 1997. V. 24. P. 728.

16. Mindermann Т., Wilson C.B. Thyrotropin-producing pituitary adenomas // J. Neurosurg. 1993. V. 79. P. 521.

17. Mixson A.J., friedman T.C., David A.K. et al. Thyrotropin-secreting pitui-tary carcinoma // J. Clin. Endocr. Met. 1993. V. 76. P. 529.

18. Nabarro J.D.N. Acromegaly // Clin. Endocr. 1987. V. 26. P. 481.

19. Persani L., Preziati D., Matthews C.H. et al. Serum levels of carboxyterminal cross-linked telopeptide of type I collagen (ICTP) in the differential diagno-sis of the syndromes of inappropriate secretion of TSH // Clin. Endocr. 1997. V. 47. P. 207.

20. Sanno N., Teramoto A., Matsuno A. et al. Clinical and immunohistochemical studies on TSH-secreting pituitary adenoma: its multihormonality and expression of Pit-1 // Mod. Pathol. 1994. V. 7. P. 893.

21. Smallridge R.C. Metabolic, physiologic and clinical indexes of thyroid function. Werner and Ingbar's The Thyroid. 7th ed. Philadelphia: Lippincott, 1996. P. 397.

22. Tannahill L.A., Visser T.J., McCabe C.J. et al. Disregulation of iodothyronine deiodinase enzyme expression and function in human pituitary tumors // Clin. Endocr. 2002. V. 56. P. 735.

23. Terzolo M., Orlandi F., Basseti M. et al. Hyperthyroidism due to a pituitary adenoma composed of two different cell types, one secreting alpha-subunit alone and another cosecreting alpha-subunit and thyrotropin // J. Clin. Endocr. Met. 1991. V. 72. P. 415.

24. Yamakita N., Ikeda Т., Murai T. et al. Thyrotropin-producing pituitary adenoma discovered as a pituitary incidentaloma. Intern Med. 1995. V. 34 (11). P. 1055–1060.


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For citations:


 ,  ,  ,  ,  ,   Thyrotropin-producing adenoma: diagnostic challenges (Сase report). Clinical and experimental thyroidology. 2011;7(2):68-73. (In Russ.) https://doi.org/10.14341/ket20117268-73

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