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Iodine-prophylaxis in Adolescents

https://doi.org/10.14341/ket20095234-40

Abstract

The aim of the study is to estimate a current state of iodine deficiency problem and necessity group (individual) iodine prophylaxis in adolescent living in iodine deficiency regions. Materials and methods. One-stage epidemiological survey was carried on in two cities: Smolensk and Kazan. There were examined 420 children at the age of 14–16 years. Research methods included: clinical survey, an estimation physical developments estimation (height and weight measurement), ultrasound examination of a thyroid, urinary iodine concentration(UI) measuring, analysis of thyrotropin (TSH) and thyroperoxidase autoantibody. The main results. Prevalence of a diffuse goiter in both regions was approximately equal and corresponded to mild iodine deficiency (10.5% in Smolensk and 8% in Kazan). At the same time, the mean of thyroid volume was significantly higher in a group of teenagers surveyed in Smolensk. Also we revealed that prevalence of nodule goiter is more frequent in Smolensk in than in Kazan. UI in schoolchildren in Smolensk corresponds to mild iodine deficiency (median UI is 61 μg/L). UI indicators in Kazan vice versa correspond to normal level of iodine consumption (median UI is 117.5 μg/L). Essential distinction of iodine sufficiency level has direct relation with iodine prophylactic measures in regions. Data in adolescents in Smolensk reveal insufficient iodine consumption and possible related risk of iodine deficiency disorders development. Conclusion. The obtained results show the necessity of group iodine prophylactic measures in adolescents who livein iodine deficiency regions with any severity level.

References

1. Герасимов Г.А., Фадеев В.В., Свириденко Н.Ю. и др. Йододефицитные заболевания в России. Простое решение сложной проблемы. М., 2002. С. 110–119.

2. Дедов И.И., Свириденко Н.Ю., Герасимов Г.А. и др. Оценка йодной недостаточности в отдельных регионах России // Пробл. эндокринол. 2001. № 6. С. 3–12.

3. Дедов И.И., Мельниченко Г.А., Трошина Е.А., Платонова Е.А. и др. Дефицит йода – угроза здоровью и развитию детей России. Пути решения проблемы // Нац. докл. М., 2006. 124 с.

4. Касаткина Э.П., Шилин Д.Е., Петрова Л.М. и др. Роль йодного обеспечения в неонатальной адаптации тиреоидной системы // Пробл. эндокринол. 2001. №3. С. 10–15.

5. Щеплягина Л.А. Эффективность профилактики дефицита йода у матери и ребенка.// Педиатрия. Consil. Мedic. 2006. Т. 8. № 1. С.46–51.

6. Aghini–Lombardu F., Antonangeli L., Martino E. et. al. The spectrum of thyroid disorders in an iodine – deficient community: the Pescopagano survey// J. Clin. Endocrinol. Metab. 1999.V. 84. N 2. P. 561–566.

7. Hollowell J.G., Staehling N.W., Flanders W.D. et al. Serum TSH T(4), and thyroid antibodies in the United States population (1988–1994): National Health and Nutrition Examination Survey (NHANES III). // J. Clin. Endocrinol. Metab. 2002. V. 87. Р. 489–499.

8. Jaksic J., Dumic M., Filipovic B et al. Thyroid diseases in a school population with thyromegaly// Arch. Dis. Child. 1994. V. 70. P. 103–106.

9. Kabelitz M., Liesenkotter K.P., Stach B. The prevalence of antithyroid peroxidase antibodies and autoimmune thyroiditis in chil% dren and adolescents in an iodine replete area // Eur. J. Endocrinol. 2003. V. 148. P. 301–307.

10. Niedziela M. Pathogenesis, diagnosis and management of thyroid nodule in children// Endocrin. Related Cancer. 2006. V 13. P. 427–453.

11. Völzke H, Alte D, Kohlmann T, et al. Reference intervals of serum thyroid function tests in a previously iodine-deficient area // Thyroid 2005. V. 15. P. 279–285.

12. Wang C., Crapo M.L. The epidemiology of thyroid disease and implications for screening // Endocrinol. Metab. Clin. North. Am. 1997. V. 26. P. 189–218.

13. World Health Organization. Assessment of iodine deficiency disorders and monitoring their elimination. A guide for programme managers, Second Edition. WHO, 2002. P. 37–41.

14. Zimmermann M.B. et al. New reference values for thyroid volume by ultrasound in iodine-sufficient schoolchildren: a World Health Organization/Nutrition for Health and Development Iodine Deficiency Study Group Report // Am. J. Clin. Nutrit. 2004. V. 79. P. 231–237.


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 ,  ,  ,  ,   Iodine-prophylaxis in Adolescents. Clinical and experimental thyroidology. 2009;5(2):34-40. (In Russ.) https://doi.org/10.14341/ket20095234-40

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