Preview

Clinical and experimental thyroidology

Advanced search

Echocardiographycal Features in Patients with Hypothyroidism of Different Sevirity due to Hashimoto’s Thyroiditis

https://doi.org/10.14341/ket20095245-50

Abstract

The purpose of the study was to evaluate haemodynamics and geometrical parameters obtained during echocardiography of patients with various clinical types of autoimmune thyroid disease (ATD). 77 patients with verified diagnosis of ATD were surveyed: 73 (94.8%) female and 4 (5.2%) male. All ATD patients were divided into 3 groups depending on function of the thyroid. Decrease in concentration of thyroid hormones at SCH and CH leads to decrease of contractility of heart. Obtained data shows that SCH and CH increase the rate of development fo eccentric hypertrophies of myocardium (25.9 and 60%, respectively, р <0.04). Patients with SCH and CH are characterised by moderate changes of morphofunctional parameters of heart consisting of increase in size and dilation of cavities of the left auricle and thickness of the left myocardial wall (a relative hypertrophy).

References

1. Божжа А.П., Сухорукова Т.А. // Пробл. эндокринол. 1989. № 6. С. 71–75.

2. Новицкая А.Б., Стронгин Л.Г., Некрасова Т.А., Конторщикова К.Н. Особенности перекисного окисления липидов и гемодинамики у больных с субклиническим гипотиреозом // Клин. тиреоидол. 2004. Т. 2. № 4. С. 27–31.

3. Фадеев В.В., Мельниченко Г.А. Гипотиреоз / Руководство для врачей. Москва, 2004. 288 с.

4. Angejla B. J., Grossman W. Evaluation and management of dias# tolic heart failure // Circurlation. 2003. V. 107. P. 659–663.

5. Bauwens F.R., Duprez D.A., De Buyzere M.L. et. аl. Influence of the arterial blood pressure and nonhemodynamic factors on left ven# tricular hypertrophy in moderate essential hypertension //Am. J. Cardiol. 1991. V. 68. Р. 929–935.

6. Biondi B., Palmieri E. A., Lombardi G. et al. Effects of subclinical thyroid dysfunction on the heart // Ann. Intern. Med. 2002. V. 137. N 11. P. 904–914.

7. Devereux R. B., Pickering Т.О., Harshfield G.A. et al. Left ventricular hypertrophy in patients with hypertension: importance of blood pressure responses to regularly recurring stress // Circulation. 1988. V. 68. Р.470–476.

8. Faber J., Petersen L., Wiinberg N. et al. Hemodynamic changes after levothyroxine treatment in subclinical hypothyroidism // Thyriod. 2002. V. 12. P. 505–510

9. Levei G., Klein L. Catecholamine#thyroid hormone interactions and the cardiovascular manifestations of hyperthyroidism // Am. J. Med. 1990. V. 88. Р. 641–646.

10. Hak A. E. et al. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study // Ann. Intern. Med. 2000. V. 132 (4). P. 270–278.

11. Klein I., Ojamaa K. Thyroid hormone and the cardiovascular system // N. Engl. J. Med. 2001. V. 344. P. 50–509.

12. Monzani F., Di Bello V., Caraccio N., et al. Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy // J. Clin. Endocrinol. Metab. 2003. V. 86. P. 1110–1115.

13. Levej G.S. Catecholamine sensitivity, thyroid hormone and the heart: reevaluation // Am. J. Med. 1971. V. 50. P. 413–420.

14. Policar R., Kennedy B. Plasma norepinephrine kinetics, dopamine – hydroxylase and chromogramin#A in hypothyroid patient before and following replacement therapy // J Сlin. Endocr. Metab. 1990. V. 70. Р. 277– 281.

15. Taddei S., Caraccio N., Virdis A. et all. // J. Clin. Endocrinol. Metab. 2003. V. 88. P. 3731–3737.

16. Segal S. Calcium is the first messenger for the action of thyroid hormone at the level of the plasma membrane: First evidence for an acute effect of thyroid hormone on calcium uptake in the heart // Endocrinol. 1990. V. 16. Р. 2693–2702.

17. Schiller N.B. Two#dimensional echocardiography determination of left ventricular volume, systolic function, and mass. Summary and discussion of the 1989 recommendations of the American Society of Echocardiography // Circulation. 1991. V. 84 (Suppl. 3). P. 280.

18. Vitale G., Galderisi M., Lupoli G. A. et al. Left ventricular myocardial impairment in subclinical hypothyroidism assessed by a new ultrasound tool: pulsed tissue Doppler // Clin. Endocrinol. Metab. 2002. V. 87. P. 4350–4355

19. Wolfgang H. Biochemical Basis of Thyroid Hormone Action in the Heart // Am. J. Med. 1990.V. 88. Р. 626–629.


Review

For citations:


 ,  ,  ,   Echocardiographycal Features in Patients with Hypothyroidism of Different Sevirity due to Hashimoto’s Thyroiditis. Clinical and experimental thyroidology. 2009;5(2):45-50. (In Russ.) https://doi.org/10.14341/ket20095245-50

Views: 432


ISSN 1995-5472 (Print)
ISSN 2310-3787 (Online)