Glomerular Filtration Rate and Interleukin-8 Level in Patients with Graves' Disease
https://doi.org/10.14341/ket20139446-51
Abstract
In patients with various diseases with kidney’s involvement, there was a significant increase of IL-8 urine concentration. In chronic pyelonephritis increase of urine IL-8 have been suggested as an indicator of active renal fibrogenesis. Thyroid hormones affect the kidneys through various mechanisms. The most exact indicator of renal function now is the glomerular filtration rate (GRF). Aim. To study the GFR and IL-8 levels in patients with Graves' disease. Results. The study included 95 patients with Graves' disease in the decompensated thyrotoxicosis stage. GFR above 120 ml/min occurred in 37.9% of patients; 90-120 ml/min - in 40%; below 90 ml/min - in 22.1%. Reduction GFR below 60 ml/min weren’t observed. There is a direct correlation between GFR and triiodothyronine (T3) level (r s = 0.45; p = 0.001), the inverse correlation between GFR and IL-8 level (r s = -0.53; p = 0.037). Conclusion. In patients with Graves' disease detected correlation between T3 level and GFR increase. While GFR reduced it was recorded the IL-8 elevation in serum.
About the Authors
M Gryaznovavrach-endokrinolog konsul'tativno-diagnosticheskoy polikliniki GBUZ IOKB; zaochnaya aspirantka kafedry endokrinologii i klinicheskoy farmakologii GBOU VPO IGMU MZ RF
L Khamnueva
doktor med. nauk, professor, zav. kafedroy endokrinologii i klinicheskoy farmakologii GBOU VPO “Irkutskiy gosudarstvennyy meditsinskiy universitet” MZ RF
A Davydova
kand. med. nauk, dotsent kafedry gospital'noy terapii GBOU VPO IGMU MZ RF
G Orlova
doktor med. nauk, professor, zav. kafedroy gospital'noy terapii GBOU VPO IGMU MZ RF.
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Review
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, , , Glomerular Filtration Rate and Interleukin-8 Level in Patients with Graves' Disease. Clinical and experimental thyroidology. 2013;9(4):46-51. (In Russ.) https://doi.org/10.14341/ket20139446-51
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