Evaluation of the Results of Repeated FNA in Patients with Nodular Colloid Goiter
https://doi.org/10.14341/CET201410232-37
Abstract
Article is devoted to the relevance of the application of needle aspiration (FNA), as well as the feasibility of re (FNA) in patients with initially benign thyroid nodules. The study involved 120 patients who underwent FNA, the results of which were diagnosed nodular colloid goiter. During repeated FNA of patients with benign thyroid cytologic diagnosis changed in 16.6% of patients ( n = 20), and the conclusion from benign to “suspicious for malignancy” occurred in one patient (0.8%). Long-term observation of patients with initially benign conclusion leads to an increased number of repeat FNAs that not only beneficial in terms of funding, but uninformative, as the percentage identified of malignancies statistically insignificant. The above observation showed that the use of re-FNA in patients with proven benign thyroid nodules impractical even when data are available for the growth of the nodules and the change in concentration of TSH and regardless of age.
About the Authors
G SemkinaEndocrinology Research Centre
A Abrosimov
Medical Radiology Research Center
F Abdulhabirova
Endocrinology Research Centre
V Vanushko
Endocrinology Research Centre
References
1. Singer PA, Cooper DS, Daniels GH et al. Treatment guidelines for patients with thyroid nodules and well-differentiated thyroid cancer. Arch Intern Med. 1996;156:2165-2172.
2. Wong CKM, Wheeler MH. Thyroid nodules: rational management. World J Surg. 2000;24:934-941.
3. Hegedus L, Bonnema SJ, Bennedbæk FN. Management of simple nodular goiter: current status and future perspectives. Endocr Rev. 2003;24:102-132.
4. Hegedus L. The thyroid nodule. N Eng J Med. 2004;351:1764-1771.
5. Singh RS, Wang HH. Timing of repeat thyroid fine-needle aspiration in the management of thyroid nodules. Acta Cytologica. 2011;55:544-548.
6. Lawrence W Jr, Kaplan BJ. Diagnosis and management of patients with thyroid nodules. J Surg Oncol. 2002;80:157-170.
7. Chehade JM, Silverberg AB, Kim J et al. Role of repeated fine-needle aspiration of thyroid nodules with benign cytologic features. Endocr Pract. 2001;7:237-243.
8. Flanagan MB, Ohori NP, Carty SE, Hunt JL. Repeat thyroid nodule fine-needle aspiration in patients with initial benign cytologic results. Am J Clin Pathol. 2006;125:698-702.
9. Aguilar J, Rodriguez JM, Flores B et al. Value of repeated fine-needle aspiration cytology and cytologic experience in the management of thyroid nodules. Otolaryngol Head Neck Surg. 1998;119:121-124.
10. Merchant SH, Izquierdo R, Khurana KK. Is repeated fine-needle aspiration cytology useful in the management of patients with benign nodular thyroid disease? Thyroid. 2000;10:489-492.
11. Orlandi A, Puscar A, Capriata E et al. Repeated fine-needle aspiration of the thyroid in benign nodular thyroid disease: critical evaluation of long-term follow-up. Thyroid. 2005;15:274-278.
12. Oertel YC, Miyahara-Felipe L, Mendoza MG, Yu K. Value of repeated fine needle aspirations of the thyroid: An analysis of over ten thousand FNAs. Thyroid. 2007;17:1061-1066.
13. Shin JH, Han BK, Ko K et al. Value of repeat ultrasound-guided fine-needle aspiration in nodules with benign cytological diagnosis. Acta Radiol. 2006;47:469-473.
14. Lee S, Skelton TS, Zheng F et al. The biopsy-proven benign thyroid nodule: Is long-term follow-up necessary? J Am Coll Surg. 2013;1:8.
15. Haymart MR, Repplinger DJ, Leverson GE et al. Higher serum thyroid stimulating hormone level in thyroid nodule patients is associated with greater risks of differentiated thyroid cancer and advanced tumor stage. J Clin Endocrinol Metab. 2008;93:809-814.
16. Boelaert K, Horacek J, Holder RL. Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration. J Clin Endocrinol Metab. 2006; 91:4295-4301.
17. Boelaert K. The association between serum TSH concentration and thyroid cancer. Endocrine-Related Cancer. 2009;16:1065-1072.
18. Fiore E, Rago T, Provenzale MA et al. Lower levels of TSH are associated to a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role. Endocrine-Related Cancer. 2009;16:1251-1260.
19. Brewer C, Yeager N, Di CA. Thyroid-stimulating hormone initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT. Cancer Research. 2007;67:8002-8006.
20. Yeager N, Klein-Szanto A, Kimura S, Di CA. Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis. Cancer Research. 2007;67:959-966.
21. Cooper DS, Doherty GM, Haugen BR et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009; 19:1167e1214.
22. AACE/AME/ETA Thyroid Nodule Guidelines. Endocr Pract. 2010;16:1-43.
23. Ванушко В.Э., Кузнецов Н.С., Бельцевич Д.Г., и др. Прицельная тонкоигольная пункционная биопсия в диагностике рака щитовидной железы // Хирургия. 2003;10:67-72.
24. Seong N. Ultrasonography-guided fine-needle aspiration of thyroid incidentaloma: Correlation with pathological findings. Clin Endocrinol. 2004;60:145-147
Review
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, , , Evaluation of the Results of Repeated FNA in Patients with Nodular Colloid Goiter. Clinical and experimental thyroidology. 2014;10(2):32-37. (In Russ.) https://doi.org/10.14341/CET201410232-37
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