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Клиническая и экспериментальная тиреоидология

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Лечение первичного гипотиреоза: нерешенные вопросы

https://doi.org/10.14341/ket2015122-34

Аннотация

Первичный гипотиреоз является одним из наиболее распространенных эндокриннвж заболеваний. По современным представлениям, лечение манифестного гипотиреоза подразумевает назначение заместительной монотерапии левотироксином (L-T4), что обеспечивает поддержание компенсации заболевания. Достижение компенсации в подавляющем большинстве случаев приводит к нормализации самочувствия больных, купированию симптомов гипотиреоза и, как следствие, повышению качества жизни. Однако, по данным разных авторов, у 5—10% пациентов с гипотиреозом, получающих L-T4, сохраняются сниженное настроение, повышенные уровни тревожности и депрессии, несмотря на поддержание стойко нормального уровня ТТГ. В обзоре обсуждаются подходы к ведению таких пациентов и как один из вариантов — перевод на комбинированную терапию левотироксином и трийодтиронином (L-T4+T3).

Об авторах

Татьяна Борисовна Моргунова
ГБОУ ВПО "Первый МГМУ им. И.М. Сеченова", Москва
Россия
Кандидат медицинских наук, ассистент кафедры эндокринологии Лечебного факультета


Меруерт Шайзиндиновна Мадиярова
ГБОУВПО "Первый МГМУ им. И.М. Сеченова", Москва
Россия
аспирант кафедры эндокринологии Лечебного факультета


Валентин Викторович Фадеев
ГБОУ ВПО "Первый МГМУ им. И.М. Сеченова", Москва
Россия
доктор медицинских наук, профессор, заведующий кафедрой эндокринологии Лечебного факультета


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Рецензия

Для цитирования:


Моргунова Т.Б., Мадиярова М.Ш., Фадеев В.В. Лечение первичного гипотиреоза: нерешенные вопросы. Клиническая и экспериментальная тиреоидология. 2015;11(1):22-34. https://doi.org/10.14341/ket2015122-34

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