Preview

Clinical and experimental thyroidology

Advanced search

Iodine deficiency: current status

https://doi.org/10.14341/ket2015112-21

Abstract

One of the priorities of health care in most countries is the prevention of iodine deficiency disorders (IDD). About two billion people live in areas of natural iodine deficiency. It is known that insufficient intake of iodine in utero and in early childhood is the greatest danger. Changes caused by iodine deficiency in these periods of life manifest in irreversible defects of intellectual and physical development. However, the entire spectrum of IDD is wide and extends from reproductive disorders to specific thyroid diseases.

According to the World Health Organization (UNICEF), in 96 countries with iodine deficiency are already laws and regulations on mandatory salt iodization, only 13 countries do not have the law, including Russia. It is proved that the Russian population continues to live in conditions of uncompensated iodine deficiency.

In this connection it is extremely relevant conduct mass iodine prophylaxis and individual using preparations containing a physiological dose of iodine (such as Jodomarin) in high-risk groups on a statutory basis.

About the Author

Nadezhda Mikhailovna Platonova
Endocrinology Research Centre, Moscow
Russian Federation
MD, PhD, Professor
Competing Interests: Автор декларирует отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.


References

1. Hetzel B. Iodine deficiency disorders (idd) and their eradication. Lancet. 1983;322(8359):1126-1129. doi: 10.1016/s0140-6736(83)90636-0

2. Zimmermann MB, Jooste PL, Pandav CS. Iodine-deficiency disorders. Lancet. 2008;372(9645):1251-1262. doi: 10.1016/s0140-6736(08)61005-3

3. Glinoer D, De Nayer P, Delange F, et al. A randomized trial for the treatment of mild iodine deficiency during pregnancy: Maternal and neonatal effects. J Clin Endocrinol Metab. 1995;80(1):258-269. doi: 10.1210/jcem.80.1.7829623

4. Aghini-Lombardu F, Antonangeli L, Martino E, et al. The spectrum of thyroid disorders in an iodine - deficient community: the Pescopagano survey. J Clin Endocrinol Metab. 1999;84(2):561-566.

5. De Benoist B, McLean E, Andersson M, Rogers L. Iodine deficiency in 2007: global progress since 2003. Food Nutr Bull. 2008;29:195-202.

6. Дедов И.И., Герасимов Г.А., Свириденко Н.Ю. Йододефи-цитные заболевания в Российской Федерации (эпидемиология, диагностика, профилактика). Методическое пособие. — М.; 1999. [Dedov II, Gerasimov GA, Sviridenko NYu. Iododefitsitnye zabolevaniya v Rossiiskoi Federatsii (epidemi-ologiya, diagnostika, profilaktika). Metodicheskoe posobie. Moscow; 1999. (In Russ).]

7. World Health Organization, UNICEF, International Council for Control of Iodine Deficiency Disorders. Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. 3rd ed. Geneva: World Health Organization;2007.

8. WHO, UNICEF, ICCIDD. Assessment of iodine deficiency disorders and monitoring their elimination. Geneva: World Health Organization; 2001.

9. Andersson M, De Benoist B, Delange F, et al. Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: Conclusions and recommendations of the technical consultation. Public Health Nutr. 2007;10(12A). doi: 10.1017/s1368980007361004

10. Alexander WD, Harden RM, Harrison MT, et al. Some aspects of the absorption and concentration of iodide by the alimentary tract in man. Proc NutriSoc. 2007;26(01):62-67. doi: 10.1079/pns19670013

11. Nath SK, Moinier B, Thuillier F, et al. Urinary excretion of iodide and fluoride from supplemented food grade salt. Int J Vitam Nutr Res. 1992;62:66-72.

12. Liu Y-Y, Brent GA. Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation. Trends Endocrinol Metab. 2010;21(3):166-173. doi: 10.1016/j.tem.2009.11.004

13. Chi HC, Chen C-Y, Tsai M-M, et al. Molecular functions of thyroid hormones and their clinical significance in liver-related diseases.BioMedRes7nt.2013;2013:1-16.doi:10.1155/2013/601361

14. Delange F. Iodine deficiency. In: Braverman L, Utiger R, editors. Werner and Ingbar's the thyroid: a fundamental and clinical text. Philadelphia: JD Lippincott; 2000. p. 295-316.

15. Patel J, Landers K, Li H, et al. Delivery of maternal thyroid hormones to the fetus. Trends Endocrinol Metab. 2011;22(5):164-170. doi: 10.1016/j.tem.2011.02.002

16. Glinoer D. The regulation of thyroid function in pregnancy: Pathways of endocrine adaptation from physiology to pathology. Endocr Rev. 1997;18(3):404-433. doi: 10.1210/edrv.18.3.0300

17. WHO, UNICEF, ICCIDD. Indicators for assessing Iodine Deficiency Disorders and their control through salt iodization. Geneva: World Health Organization; 1994.

18. Andersson M, De Benoist B, Rogers L. Epidemiology of iodine deficiency: Salt iodisation and iodine status. Best Pract Res Clin Endocrinol Metab. 2010;24(1):1-11. doi: 10.1016/j.beem.2009.08.005

19. Zimmermann M. Iodine deficiency and excess in children: Worldwide status in 2013. Endocr Pract. 2013;19(5):839-846. doi: 10.4158/ep13180.ra

20. Pearce EN, Andersson M, Zimmermann MB. Global iodine nutrition: Where do we stand in 2013? Thyroid. 2013;23(5):523-528. doi: 10.1089/thy.2013.0128

21. Kusic Z, Jukic T. History of endemic goiter in Croatia: from severe iodine deficiency to iodine sufficiency. CollAntropol. 2005;29:9-16.

22. Lind P, Kumnig G, Heinisch M, et al. Iodine supplementation in austria: Methods and results. Thyroid. 2002;12(10):903-907. doi: 10.1089/105072502761016539

23. Gartner R. Is iodine deficiency still relevant? MMWFortschr Med. 2007;22;149(8):29-32.

24. Baczyk M, Ruchafa M, Pisarek M, et al. Iodine prophylaxis in children population on the Wielkopolska Region area from year 1992 to 2005. Endokrynol Pol. 2006;57(2):110-115.

25. Zimmermann MB, Andersson M. Update on iodine status worldwide. Curr Opin Endocrinol Diabetes Obes. 2012;19(5):382-387. doi: 10.1097/MED.0b013e328357271a

26. Йододефицитные заболевания в Российской Федерации: время принятия решений / Под ред. Дедова И.И., Мельниченко Г.А. — М.: Конти принт; 2012. [Dedov II, Mel'nichenko GA, editors. Yododefitsitnye zabolevaniya v Rossiyskoy Federatsii: vremya prinyatiya resheniy. Moscow: Konti print, 2012. (In Russ.)]

27. Платонова Н.М. Йододефицитные заболевания (профилактика, диагностика, лечение и мониторинг): Автореф. дис. ... докт. мед. наук. — М.; 2010. [Platonova NM. Yododefitsitnye zabolevaniya (profilaktika, diagnostika, lecheie i monitoring). [the dissertation abstract] Moscow; 2010. (In Russ.)]

28. Велданова М.В. Эффективность применения калия йодида при диффузном нетоксическом зобе у детей в различных биогеохимических провинциях России. // Клиническая тиреоидология. — 2003. — Т.1. — №1 — С.14—17 [Veldanova MV. Effektivnost' primeneniya kaliya iodida pri diffuznom netoksiches-kom zobe u detei v razlichnykh biogeokhimicheskikh provintsiyakh Rossii. Clinical thyroidology. 2003;1(1):14-17 (In Russ).]

29. Касаткина Э.П. Йоддефицитные заболевания: генез, профилактика, лечение. // Фарматека. — 2003. — №8 — С.10—13. [Kasatkina EP. Ioddefitsitnye zabolevaniya: genez, profilaktika, lechenie. Farmateka. 2003;8:10-13. (In Russ).]

30. Niedziela M. Pathogenesis, diagnosis and management of thyroid nodules in children. EndocrRelat Cancer. 2006;13(2): 427-453. doi: 10.1677/erc.1.00882

31. Laurberg P, Nohr SB, Pedersen KM, et al. Thyroid disorders in mild iodine deficiency. Thyroid. 2000;10(11):951-963. doi: 10.1089/thy.2000.10.951

32. Azizi F, Kalani H, Kimiagar M, et al. Physical, neuromotor and intellectual impairment in non-cretinous schoolchildren with iodine deficiency. Int J Vitam Nutr Res. 1995;65:199-205.

33. Boyages SC, Collins JK, Maberly GF, et al. Iodine deficiency impairs intellectual and neuromotor development in apparently-normal persons. A study of rural inhabitants of north-central China. Med J Aust. 1989;150:676-682.

34. Choudhury N, Gorman KS. Subclinical prenatal iodine deficiency negatively affects infant development in Northern China. J Nutr. 2003;133:3162-3165.

35. Fenzi GF, Giusti LF, Aghini-Lombardi F, et al. Neuropsychological assessment in schoolchildren from an area of moderate iodine deficiency. J Endocrinol Invest. 2014;13(5):427-431. doi: 10.1007/bf03350696

36. Gao TS, Teng WP, Shan ZY, et al. Effect of different iodine intake on schoolchildren's thyroid diseases and intelligence in rural areas. Chin Med J (Engl). 2004;117:1518-1522.

37. Huda SN, Grantham-McGregor SM, Rahman KM, Tomkins A. Biochemical hypothyroidism secondary to iodine deficiency is associated with poor school achievement and cognition in Bangladeshi children. J Nutr. 1999;129:980-997.

38. Ojule AC, Osotimehin BO. The influence of iodine deficiency on the cognitive performance of schoolchildren in Saki, south-west Nigeria. Afr J Med Sci. 1998;27:95-99.

39. Sameroff AJ, Seifer R, Baldwin A, et al. Stability of intelligence from preschool to adolescence: The influence of social and family risk factors. ChildDevelopment. 1993;64(1):80. doi: 10.2307/1131438

40. Bougma K, Aboud F, Harding K, et al. Iodine and mental development of children 5 years old and under: A systematic review and meta-analysis. Nutrients. 2013;5(4):1384-1416. doi: 10.3390/nu5041384

41. Bleichrodt N, Born MP. A metaanalysis of research on iodine and its relationship to cognitive development. In: Stanbury FA, editor. The damaged brain of iodine deficiency cognitive, behavioral, neuromotor, educative aspects. New York [etc.]: Cognizant Communication Corporation; 1994.

42. Трошина Е.А., Соловьева С.И., Платонова Н.М. и др. Интеллектуальное развитие школьников с диффузным клиническим эутиреоидным зобом в регионах с различным йодным обеспечением. // Педиатрическая фармакология. — 2009. — Т.6. — №2 — С.43-48. [Troshina EA, Solov'eva SI, Platonova NM, et al. Intellektual'noe razvitie shkol'nikov s diffuznym klinicheskim eutireoidnym zobom v regionakh s razlichnym iodnym obespech-eniem. Pediatricheskayafarmakologiya. 2009;6(2):43-48. (In Russ).]

43. Щеплягина Л.А. Препараты йода в укреплении здоровья детей. // Consilium Medicum. Педиатрия. — 2010. — Т.12. — №1 — С.12-16 [Shcheplyagina LA. Preparaty ioda v ukreplenii zdorov'ya detei. Consilium Medicum. Pediatriya. 2010;12(1):12-16. (In Russ).]

44. Taylor PN, Okosieme OE, Dayan CM, et al. Therapy of endocrine disease: Impact of iodine supplementation in mild-to-moderate iodine deficiency: Systematic review and meta-analysis. Eur J Endocrinol. 2013;170(1):R1-R15. doi: 10.1530/eje-13-0651

45. Andersson M, De Benoist B, Delange F, et al. Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: Conclusions and recommendations of the technical consultation. Public Health Nutr. 2007;10(12A). doi: 10.1017/s1368980007361004

46. Untoro J, Managasaryan N, de Benoist I, Darnton-Hill I. Reaching optimal iodine nutrition in pregnant and lactating women and young children: programmatic recommendations. Public Health Nutr. 2007;10(12):1527-1529.

47. World Health Organization, United Nutriones Children's Fund, International Council for the Control of Iodine Deficiency Disorders. Assessment of iodine deficiency disorders and monitoring their elimination. 3rd ed. Geneva, 2007.


Review

For citations:


Platonova N.M. Iodine deficiency: current status. Clinical and experimental thyroidology. 2015;11(1):12-21. (In Russ.) https://doi.org/10.14341/ket2015112-21

Views: 1292


ISSN 1995-5472 (Print)
ISSN 2310-3787 (Online)