Circadian rhythm of TSH secretion during TSH-suppression therapy
Abstract
Тo investigate circadian rhythm of TSH secretion during TSH-suppression therapy. 17 patients taking TSH-suppression therapy, at the age of 18–60 years have been included. Measurements of serum TSH were performed at8.00–9.00h and 14.00–16.00 during the day. The median of TSH concentrations in the morning was 0,016mU/l, at the daytime – 0.015mU/l. The amplitude of TSH circadian variability reached 200% (Me – 19%). At boundary TSH value stability of TSH-suppression can be broken. As specifying action research in similar situations can be measurement of serum TSH in other time.
References
1. Coleman P.M., Babb P., Damiecky P. et al. Cancer Survival Trends in England and Wales 1971–1995 // Deprivat. NHSReg. Ser. SMPS. 1999. N61. P. 471–478.
2. Evans P.J., Weeks I., Jones M.K. et al. The circadian variation of thyrotrophin in patients with primary thyroidal disease // Clin. Endocrinol. 1986. V. 24(4). P. 343–348.
3. Harris P.E. The management of thyroid cancer in adults: a review of new guidelines // Clin. Med. 2002. V. 2(2). P. 144–146.
4. Persani L., Terzolo M., Asteria C. et al. Circadian variations of thyrotropin bioactivity in normal subjects and patients with primary hypothyroidism // J. Clin. Endocrin. Metab. 1995. V. 80. P. 2722–2728.
Review
For citations:
, , Circadian rhythm of TSH secretion during TSH-suppression therapy. Clinical and experimental thyroidology. 2011;7(1):55-57. (In Russ.)
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