The objective of the research is the analysis of blood lymphocyte composition and the rate of infection by the herpes simplex virus (HSV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in patients with AIT. Two men and twenty six women (with the average age 44.0 ± 2.3 years) ill with the disease for 6.0 ± 2.7 years were examined. 85.7% of the ill were in the euthyroid state, 14.3% were in hypothyroidism. 25% ofthe patients were diagnosed with atrophic AIT, 60,7% got the diagnoses of fibroid and fibronodular AIT and 14.3% got hypertrophic AIT diagnoses. It was found that the course of AIT was accompanied with the increase of the rate of CD20 +-lymphocytes in blood at the normal number of CD3 +-, CD4 +-, CD8 +- и CD56 + cells. The IgG to the HSV was found in 92.9% patients with AIT, to the CMV - in 96.4% cases, to the pre-early antigen (ЕА) of CMV (acute infection) - in 39.3% patients and to the nuclear antigen of EBV (КА) (late past-infection) - in 67.6% cases. In two cases we found EBV-IgG to EA and КА simultaneously (late stage of primary EBV-infection or reactivation of its chronic form). It was proved that 39.3% of the patients with AIT associate this disease with acute cytomegalovirus infection.

In 22 patients aged 24-65 without diabetes mellitus (8 with primary hypothyroidism, 9 with nontoxic nodular goiter and 5 with differentiated thyroid carcinoma not less than 6 mo after surgery) the study was conducted with the aim to discover whether metformin (1 g/day) added to the fixed dose of L-thyroxine (in average 66.4 mcg/day) demonstrates any additional inhibitory effect on blood serum TSH level. In 11 responding to such treatment patients (practically, not depending of the type of thyroid pathology) this additional effect was rather significant (-72.8%, р = 0.035) and was not associated with change in the fT4 level. Supporting and expanding observations of R. Vigersky et al. (2006), this approach warrants further study especially in relation to discovery of the factors predicting mentioned favourable metformin effect.