Проект клинических рекомендаций по гипотиреозу
https://doi.org/10.14341/ket12702
Аннотация
Гипотиреоз — одно из наиболее распространенных эндокринных заболеваний. Более 99% всех случаев гипотиреоза у взрослых приходится на первичный гипотиреоз. Наиболее часто гипотиреоз развивается вследствие хронического аутоиммунного тиреоидита, а также после медицинских манипуляций (ятрогенный гипотиреоз) — послеоперационный или в исходе терапии радиоактивным йодом. В статье представлен проект клинических рекомендаций по диагностике, лечению гипотиреоза в разных группах пациентов, включая беременных женщин.
Об авторах
В. В. ФадеевРоссия
Фадеев Валентин Викторович, д.м.н., член-корр. РАН, профессор, кафедра эндокринологии №1 Института клинической медицины им. Н.В. Склифосовского, 119991, Москва, ул. Трубецкая, д. 8, стр. 2, eLibrary SPIN: 6825-8417
Т. Б. Моргунова
Россия
Моргунова Татьяна Борисовна, к.м.н., eLibrary SPIN: 3705-8599, Москва
Г. А. Мельниченко
Россия
Мельниченко Галина Афанасьевна, д.м.н., профессор, академик РАН, eLibrary SPIN: 8615-0038, Москва
И. И. Дедов
Россия
Дедов Иван Иванович, д.м.н., профессор, академик РАН, Researcher ID: D-3729-2014; Scopus Author ID: 7101843976;
eLibrary SPIN: 5873-2280, Москва
Список литературы
1. Национальное руководство. Эндокринология / Под редакцией И.И. Дедова, Г.А. Мельниченко. — М.: «Геотар-Медиа»; 2016. — С. 604-616, 635-645.
2. Гарднер Д., Шобек Д. Базисная и клиническая эндокринология — М.: Издательство «Бином»; 2011. — С. 304-364.
3. Фадеев В.В., Мельниченко Г.А. Гипотиреоз (руководство для врачей). — М.: РКИ Соверо пресс; 2002. — С. 58-112.
4. Киеня Т.А., Моргунова Т.Б., Фадеев В.В. Вторичный гипотиреоз у взрослых: диагностика и лечение // Клиническая и экспериментальная тиреоидология. — 2019. — Т. 15. — №2 — С. 64-72. doi: https://doi.org/10.14341/ket10303
5. Meyerovitch J. Serum Thyrotropin Measurements in the Community. Arch Intern Med. 2007;167(14):1533-1538. doi: https://doi.org/10.1001/archinte.167.14.1533
6. Neumann S, Raaka BM, Gershengorn MC. Constitutively Active Thyrotropin and Thyrotropin-Releasing Hormone Receptors and Their Inverse Agonists. Methods in Enzymology. 2010;485:147-160. doi: https://doi.org/10.1016/B978-0-12-381296-4.00009-9
7. Barbesino G, Sluss PM, Caturegli P. Central Hypothyroidism in a Patient with Pituitary Autoimmunity: Evidence for TSH-Independent Thyroid Hormone Synthesis. J Clin Endocrinol Metab. 2012;97(2):345-350. doi: https://doi.org/10.1210/jc.2011-1591
8. Persani L. Central Hypothyroidism: Pathogenic, Diagnostic, and Therapeutic Challenges. J Clin Endocrinol Metab. 2012;97(9):3068-3078. doi: https://doi.org/10.1210/jc.2012-1616
9. Negro R, Formoso G, Mangieri T, et al. Levothyroxine Treatment in Euthyroid Pregnant Women with Autoimmune Thyroid Disease: Effects on Obstetrical Complications. J Clin Endocrinol Metab. 2006;91(7):2587-2591. doi: https://doi.org/10.1210/jc.2005-1603
10. Glinoer D, Riahi M, Grün JP, Kinthaert J. Risk of subclinical hypothyroidism in pregnant women with asymptomatic autoimmune thyroid disorders. J Clin Endocrinol Metab. 1994;79(1):197-204. doi: https://doi.org/10.1210/jcem.79.1.8027226
11. Karmisholt J, Andersen S, Laurberg P. Variation in Thyroid Function Tests in Patients with Stable Untreated Subclinical Hypothyroidism. Thyroid. 2008;18(3):303-308. doi: https://doi.org/10.1089/thy.2007.0241
12. Andersen S, Pedersen KM, Bruun NH, Laurberg P. Narrow individual variations in serum T 4 and T 3 in normal subjects: a clue to the understanding of subclinical thyroid disease. J Clin Endocrinol Metab. 2002;87:1068-1072.
13. Somwaru LL, Rariy CM, Arnold AM, Cappola AR. The Natural History of Subclinical Hypothyroidism in the Elderly: The Cardiovascular Health Study. J Clin Endocrinol Metab. 2012;97(6):1962-1969. doi: https://doi.org/10.1210/jc.2011-3047
14. Surks MI, Ortiz E, Daniels GH, et al. Subclinical Thyroid Disease. JAMA. 2004;291(2):228-238. doi: https://doi.org/10.1001/jama.291.2.228.
15. Alexopoulou O, Beguin C, De Nayer P, Maiter D. Clinical and hormonal characteristics of central hypothyroidism at diagnosis and during follow-up in adult patients. Eur J Endocrinol. 2004;150(1):1-8. doi: https://doi.org/10.1530/eje.0.1500001
16. Persani L, Cangiano B, Bonomi M. The diagnosis and management of central hypothyroidism in 2018. Endocr Connect. 2019;8(2):R44-R54. doi: https://doi.org/10.1530/EC-18-0515
17. Grunenwald S, Caron P. Central hypothyroidism in adults: better understanding for better care. Pituitary. 2015;18(1):169-175. doi: https://doi.org/10.1007/s11102-014-0559-8
18. Constine LS, Woolf PD, Cann D, et al. Hypothalamic-Pituitary Dysfunction after Radiation for Brain Tumors. N Engl J Med. 1993;328(2):87-94. doi: https://doi.org/10.1056/NEJM199301143280203
19. Snyder PJ, Fowble BF, Schatz NJ, et al. Hypopituitarism following radiation therapy of pituitary adenomas. Am J Med. 1986;81(3):457-462. doi: https://doi.org/10.1016/0002-9343(86)90299-8
20. Fernandez-Rodriguez E, Bernabeu I, Castro AI, Casanueva FF. Hypopituitarism After Traumatic Brain Injury. Endocrinol Metab Clin North Am. 2015;44(1):151-159. doi: https://doi.org/10.1016/j.ecl.2014.10.012
21. Krewer C, Schneider M, Schneider HJ, et al. Neuroendocrine Disturbances One to Five or More Years after Traumatic Brain Injury and Aneurysmal Subarachnoid Hemorrhage: Data from the German Database on Hypopituitarism. J Neurotrauma. 2016;33(16):1544-1553. doi: https://doi.org/10.1089/neu.2015.4109
22. Raber W, Gessl A, Nowotny P, Vierhapper H. Thyroid Ultrasound Versus Antithyroid Peroxidase Antibody Determination: A Cohort Study of Four Hundred Fifty-One Subjects. Thyroid. 2002;12(8):725-731. doi: https://doi.org/10.1089/105072502760258712
23. Brent GA. Mechanisms of thyroid hormone action. J Clin Invest. 2012;122(9):3035-3043. doi: https://doi.org/10.1172/JCI60047
24. Dow KH, Ferrell BR, Anello C. Quality-of-Life Changes in Patients with Thyroid Cancer After Withdrawal of Thyroid Hormone Therapy. Thyroid. 1997;7(4):613-619. doi: https://doi.org/10.1089/thy.1997.7.613
25. Mandel SJ. Levothyroxine Therapy in Patients with Thyroid Disease. Ann Intern Med. 1993;119(6):492-502. doi: https://doi.org/10.7326/0003-4819-119-6-199309150-00009.
26. Benvenga S, Bartolone L, Squadrito S, et al. Delayed Intestinal Absorption of Levothyroxine. Thyroid. 1995;5(4):249-253. doi: https://doi.org/10.1089/thy.1995.5.249.
27. Perez CL, Araki FS, Graf H, de Carvalho GA. Serum thyrotropin levels following levothyroxine administration at breakfast. Thyroid. 2013;23(7):779-784. doi: https://doi.org/10.1089/thy.2012.0435
28. Wenzel KW, Kirschsieper HE. Aspects of the absorption of oral L-thyroxine in normal man. Metabolism. 1977;26(1):1-8. doi: https://doi.org/10.1016/0026-0495(77)90121-4
29. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA. 2000;283(21):2822-2825. doi: https://doi.org/10.1001/jama.283.21.2822
30. Ross DS. Serum thyroid-stimulating hormone measurement for assessment of thyroid function and disease. Endocrinol Metab Clin North Am. 2001;30(2):245-264. doi: https://doi.org/10.1016/S0889-8529(05)70186-9
31. Woeber KA. Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. J Endocrinol Invest. 2002;25(2):106-109. doi: https://doi.org/10.1007/BF03343972
32. Zamfirescu I, Carlson HE. Absorption of Levothyroxine When Coadministered with Various Calcium Formulations. Thyroid. 2011;21(5):483-486. doi: https://doi.org/10.1089/thy.2010.0296
33. Campbell NRC. Ferrous Sulfate Reduces Thyroxine Efficacy in Patients with Hypothyroidism. Ann Intern Med. 1992;117(12):1010-1013. doi: https://doi.org/10.7326/0003-4819-117-12-1010
34. Mayor GH, Orlando T, Kurtz NM. Limitations of Levothyroxine Bioequivalence Evaluation: Analysis of An Attempted Study. Am J Ther. 1995;2(6):417-432.
35. Eisenberg M, Distefano JJ. TSH-Based Protocol, Tablet Instability, and Absorption Effects on L-T 4 Bioequivalence. Thyroid. 2009;19(2):103-110. doi: https://doi.org/10.1089/thy.2008.0148
36. Biondi B. Effects of Subclinical Thyroid Dysfunction on the Heart. Ann Intern Med. 2002;137(11):904-914. doi: https://doi.org/10.7326/0003-4819-137-11-200212030-00011.
37. Paul TL. Long-term L-Thyroxine Therapy Is Associated With Decreased Hip Bone Density in Premenopausal Women. JAMA J Am Med Assoc. 1988;259(21):3137. doi: https://doi.org/10.1001/jama.1988.03720210027023.
38. Roos A, Linn-Rasker SP, van Domburg RT, et al. The Starting Dose of Levothyroxine in Primary Hypothyroidism Treatment. Arch Intern Med. 2005;165(15):1714-1720. doi: https://doi.org/10.1001/archinte.165.15.1714.
39. He Q, Heo M, Heshka S, et al. Total body potassium differs by sex and race across the adult age span. Am J Clin Nutr. 2003;78(1):72-77. doi: https://doi.org/10.1093/ajcn/78.1.72
40. Taylor PN, Minassian C, Rehman A, et al. TSH Levels and Risk of Miscarriage in Women on Long-Term Levothyroxine: A Community-Based Study. J Clin Endocrinol Metab. 2014;99(10):3895-3902. doi: https://doi.org/10.1210/jc.2014-1954
41. Alexander EK, Marqusee E, Lawrence J, et al. Timing and Magnitude of Increases in Levothyroxine Requirements during Pregnancy in Women with Hypothyroidism. N Engl J Med. 2004;351(3):241-249. doi: https://doi.org/10.1056/NEJMoa040079
42. Yassa L, Marqusee E, Fawcett R, Alexander EK. Thyroid Hormone Early Adjustment in Pregnancy (The THERAPY) Trial. J Clin Endocrinol Metab. 2010;95(7):3234-3241. doi: https://doi.org/10.1210/jc.2010-0013
43. Galofré JC, Haber RS, Mitchell AA, et al. Increased Postpartum Thyroxine Replacement in Hashimoto’s Thyroiditis. Thyroid. 2010;20(8):901-908. doi: https://doi.org/10.1089/thy.2009.0391
44. Nazarpour S, Ramezani Tehrani F, Simbar M, et al. Effects of levothyroxine treatment on pregnancy outcomes in pregnant women with autoimmune thyroid disease. Eur J Endocrinol. 2017;176(2):253-265. doi: https://doi.org/10.1530/EJE-16-0548
45. Nazarpour S, Ramezani Tehrani F, Simbar M, et al. Effects of Levothyroxine on Pregnant Women With Subclinical Hypothyroidism, Negative for Thyroid Peroxidase Antibodies. J Clin Endocrinol Metab. 2018;103(3):926-935. doi: https://doi.org/10.1210/jc.2017-01850
46. Slawik M, Klawitter B, Meiser E, et al. Thyroid Hormone Replacement for Central Hypothyroidism: A Randomized Controlled Trial Comparing Two Doses of Thyroxine (T4) with a Combination of T4 and Triiodothyronine. J Clin Endocrinol Metab. 2007;92(11):4115-4122. doi: https://doi.org/10.1210/jc.2007-0297
47. Koulouri O, Auldin MA, Agarwal R, et al. Diagnosis and treatment of hypothyroidism in TSH deficiency compared to primary thyroid disease: pituitary patients are at risk of under-replacement with levothyroxine. Clin Endocrinol (Oxf ). 2011;74(6):744-749. doi: https://doi.org/10.1111/j.1365-2265.2011.03984.x
48. Agha A, Walker D, Perry L, et al. Unmasking of central hypothyroidism following growth hormone replacement in adult hypopituitary patients. Clin Endocrinol (Oxf ). 2007;66(1):72-77. doi: http://doi.org/10.1111/j.1365-2265.2006.02688.x.
49. Persani L, Brabant G, Dattani M, et al. 2018 European Thyroid Association (ETA) Guidelines on the Diagnosis and Management of Central Hypothyroidism. Eur Thyroid J. 2018;7(5):225-237. doi: https://doi.org/10.1159/000491388
50. Léger J, Olivieri A, Donaldson M, et al. European Society for Paediatric Endocrinology Consensus Guidelines on Screening, Diagnosis, and Management of Congenital Hypothyroidism. Horm Res Paediatr. 2014;81(2):80-103. doi: https://doi.org/10.1159/000358198
Дополнительные файлы
|
1. Рисунок 1. Лабораторная диагностика гипотиреоза. | |
Тема | ||
Тип | Исследовательские инструменты | |
Посмотреть
(92KB)
|
Метаданные ▾ |
|
2. Рисунок 2. Диагностика и лечение гипотиреоза во время беременности. | |
Тема | ||
Тип | Исследовательские инструменты | |
Посмотреть
(250KB)
|
Метаданные ▾ |
Рецензия
Для цитирования:
Фадеев В.В., Моргунова Т.Б., Мельниченко Г.А., Дедов И.И. Проект клинических рекомендаций по гипотиреозу. Клиническая и экспериментальная тиреоидология. 2021;17(1):4-13. https://doi.org/10.14341/ket12702
For citation:
Fadeev V.V., Morgunova T.B., Melnichenko G.A., Dedov I.I. Draft of the clinical recommendations for diagnosis and treatment of hypothyroidism. Clinical and experimental thyroidology. 2021;17(1):4-13. (In Russ.) https://doi.org/10.14341/ket12702

Контент доступен под лицензией Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).