Relationship Between Smoking, Thyroid Volume and Thyrotropin Level in Women and Men in Novosibirsk
https://doi.org/10.14341/ket20073444-48
Abstract
Purpose: to determine association between smoking habits, thyroid volume and serum TSH. METHODS: in context of internationals projects Monika (1995; age group 25—34) and HAPIEE (2005; age group 45—69) were formed representational groups of Novosibirsk. Were examinated 960 randomly selected participants. Ultrasonic scanning, clinical examination of the thyroid, serum TSH, Т4 were performed to every second. Was analyzed iodine concentration in spot urine samples. Smoking habits were investigated with questionnaires and interviews. Persons, smoking no less than one cigarette a day, were reputed as smokers. RESULTS: smokers part in the age of 25—34 was 47.5%: men — 67%, women — 28%, smokers part in the age of 45—69 was 32%: men — 52%, women — 15.5%. Median of iodine concentration in urine was: 47 microg/g in age group of 25—34 (1995 г), 107 microg/g in age group of 45—69 (2005). Thyroid volume at ultrasonic scanning was positively associated with smoking habits (p < 0.01); current smoking was strongly associated with the risk of goiter in women (odds ratio [OR] = 2.7, 95% [CI]: 1.02—7.2). Serum TSH levels to be lower in smokers than non-smokers and this has a significant bias to men than women, p = 0.001 (age group 45—69). No association was found between of solitary or multiple thyroid nodules with smoking habits.
About the Authors
u NikitinO Rymar
S Mustafina
G Simonova
S Malutina
A Ryabikiv
S Shachmatov
Yu Shepina
L Sherbakova
References
1. Галкин Р.А., Мальцев В.Н., Лопухов Н.Л., Никитин О.П. Табак или жизнь: актуальные проблемы профилактики курения. Самара: Перспектива, 2000. 164 с.
2. Женщины и табак. М.: Медицина, 1994. 134 с.
3. Иванов П. М., Осокина Л.Г., Коломенская А.Н. Динамика распространенности привычки к курению среди беременных женщин // Здравоохранение РФ. 1995. № 6. С. 26-28.
4. Brauer V.F., Below H., Kramer A. et al. The role of thiocyanate in the etiology of goiter in an industrial metropolitan area // Eur. J. of Endocrinol. 2006. V. 154(2). P. 229-235.
5. Canaris G.J., Manowitz N.R., Mayor G., Ridgway E.C. The Colorado thyroid disease prevalence study // Arch. Intern. Med. 2000. V. 160. P. 526-534.
6. Fisher C.L., Mannino D.M., Herman W.H., Frumkin H. Cigarette smoking and thyroid hormone levels in males // Internat. J. of Epidemiol. 1997. V. 26. P. 972-977.
7. Health and welfare Canada. Canadians and smoking: an undate. Ottawa: Department of Health and Welfart, 1994. p. 19.
8. Kapoor D., Jones T.H. Smoking and hormones in health and endocrine disorders // Eur. J. of Endocrinol. 2005. V. 152 (Issue 4). P. 491-499.
9. Knudsen N., Bulow I., Laurberg P. et al. Association of tobacco smoking with goiter in a low-iodine-intake area // Arch. Intern. Med. 2002. 25. V. 162(4). P. 439-443.
10. Kramer A., Meng W., Reinwein D. et al. Experimental and epidemiological studies on the interrelationship of thiocyonate and thyroid function // Z. Gesamte Hyg. 1990. V. 36. P. 383-387.
11. O’Byrne D. Курение в Европе. Профилактика неинфекционных заболеваний: опыт и перспективы. Женева: ВОЗ, 1991. С. 127-138.
12. Vestergaard Р., Rejnmark L., Weeke J. et al. Smoking as a risk factor for Graves’ disease, toxic nodular goiter, and autoimmune hypothyroidism // Thyroid. 2002. V. 12(1). P. 69-75.
13. Volzke H., Schwahn C., Kohlmann T. et al. Risk factors for goiter in a previously iodine-deficient region // Exp. Clin. Endocrinol. Diabetes. 2005 V. 113 (9). P. 507-515.
14. Yoshiuchi K., Kumano H., Nomura S. et al. Stressful life events and smoking were associated with Graves’ disease in women, but not in men // Psychosom. Med. 1998. V. 60 (2). P. 182-185.
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, , , , , , , , Relationship Between Smoking, Thyroid Volume and Thyrotropin Level in Women and Men in Novosibirsk. Clinical and experimental thyroidology. 2007;3(4):44-48. (In Russ.) https://doi.org/10.14341/ket20073444-48
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