The change of character of a passing of a Grave’s disease in St. Petersburg from 1970 till 2010

Abstract

The first time the assessment of an iodine status of St. Petersburg was carried out in 1999 by the staff of faculty therapy of Saint-Petersburg State Medical University named after academician I.P Pavlov. The median urinary iodine concentration was 105 mkg/l. In 2010 the iodine status of St. Petersburg was carried out again: the median urinary iodine concentration was significantly higher – 148 mkg/l. In this regard it was reasonable to carry out comparison of indicators of a iodine status St. Petersburg and the features of a course of a Grave’s disease before the beginning of actions for elimination of iodine deficiency (till 1999) and during active of iodine prophylaxis. There were 310 patients with a Grave’s disease, they were diagnosed during the period from 1970 to 2010. From 1980 to 2010 the number of remissions of a disease gradually decreased: till 1990 the number of remissions was 21.7% whereas from2006 to 2011 the remissions were noted at 3.9% of patients with a diffuse toxic goiter. The group of patients with disease recurrence was separately analysed. Till 1990 among the patients with recurrence of a disease developed in 207.00 ± 35.18 months, in the group of the diseased in 1990–1995 – in 73.00 ± 13.95 months, in the group among the diseased in 1996–2000 – in 22.86 ± 3.46 months, in the group 2001–2005 – in 28.59 ± 5.19 month, and in 2006–2011 – in 7.75 ± 1.21 months.The carried-out research showed that for the last 20 years the essential change of character of a course of a Grave’s disease noted. It is possible to suppose that the revealed features, most likely are connected with the change of a iodine status of the region.