Цитокинопосредованные механизмы формирования аутоиммунных тиреопатий

Обзор посвящен современным представлениям о роли цитокинов в формировании аутоиммунных тиреопатий.

аутоиммунный тиреоидит, болезнь Грейвса, цитокины, иммунопатогенез

1. Белушкина Н.Н. Молекулярные основы патологии апоптоза / Н.Н. Белушкина, С.Е. Северин // Арх. патол. 2001. №1. С. 51–60.

2. Дрометр Д.А. и др. Иммунологические аспекты дифференциальной диагностики синдрома гипертиреоза // Клин. и экспер. тиреоидол. 2007. Т. 3. №1. С. 18–23.

3. Кандрор В.И. Механизмы развития болезни Грейвса и действия тиреоидных гормонов // Клин. и экспер. тиреоидол. 2008. Т. 4. №1. С. 26–34.

4. Кандрор В.И. Эндокринология. М.: Практика, 1999.

5. Лебедев К.А., Понякина И.Д. Иммунная недостаточность (выявление и лечение). М.: Медкнига, 2003.

6. Пальцев М.А., Иванов А.А., Северин С.Е. Межклеточные взаимодействия. М.: Медицина, 2003.

7. Сарвилина И.В. Междисциплинарные исследования в медицине / Сарвилина И.В., Каркищенко В.Н., Горшкова Ю.В. М.: Техносфера, 2007. С. 112–122.

8. Фадеев В.В., Мельниченко Г.А., Герасимов Г.А. // Проб. эндокринол. 2001. Т. 47. №4. С. 7–13.

9. Arpin C., Pihlgren M., Fraichard A. et al. Effects of T3Ra1 and T3Ra2 Gene Deletion on T and B lymphocyte Development // J. Immunol. 2000. V. 164. P. 152–160.

10. Botella-Carretero J., Prados A., Manzano L. et al. The effects of thyroid hormones on circulating markers of cell-mediated immune response, as studied in patients with differentiated thyroid carcinoma before and during thyroxine withdrawal // Eur. J. Endocrinol. 2005. V. 153. P. 223–230.

11. Bretz J.D., Baker J.R. Apoptosis and autoimmune thyroid disease: following a TRAIL to thyroid destruction? // Clin. Endocrinol. 2001. V. 55. N1. P. 1–11.

12. Bretz J.D., Rymaszeweski M. TRAIL death pathway expression and induction in thyroid follicular cells // J. Biolog. Chemistr. 1999. V. 274. P. 23627–23632.

13. Caturegli P., Mariotti S., Kuppers R.C. et al. Epitopes on thyroglobulin: a study of patients with thyroid disease // Autoimmunit. 1994. V. 18. P. 41-49.

14. Fang Y., Braley-Mullen H. Cultured Murine Thyroid Epithelial Cells Expressing Transgenic Fas-Associated Death Domain-Like Interleukin-1-Converting Enzyme Inhibitory Protein Are Protected from Fas-Mediated Apoptosis // Endocrinol. 2008. V. 48. P. 3321–3329.

15. Fang Y., Sharp G.C., Braley-Mullen H. Interleukin-10 Promotes Resolution of Granulomatous Experimental Autoimmune Thyroiditis // Am. J. Pathol. 2008. V. 172. N6. P. 1591–1602.

16. Giordano C., Stassi G., De Maria R. et al. Potential involvement of Fas and its ligand in the pathogenesis of Hashimotos thyroiditis // Science. 1997. V. 275. P. 960-963.

17. Jiskra J., Antošová M., Límanová Z. et al. The relationship between thyroid function, serum monokine induced by interferon gamma and soluble interleukin-2 receptor in thyroid autoimmune diseases // Clin. Experiment. Immunol. 2009. V. 156. P. 211–216.

18. Kawakami A., Eguchi K., Matsuoka N. et al. Thyroid-stimulating hormone inhibits Fas antigen-mediated apoptosis of human thyrocytes in vitro // Endocrinol. 1996. V. 137. P. 3163–3169.

19. Kayagaki N., Yamaguchi N., Nakayama M. et al. Involvement of TNF-related apoptosis-inducing in human CD41 T-cell-mediated cytotoxicity // J. Immunol. 1999. V. 162. P. 2639–2647.

20. Mariani S.M., Krammer P.H. Surface expression of TRAIL/Apo-ligand in activated mouse T and B cells // Eur. J. Immunol. 1998. V. 28. P. 1492–1498.

21. Marino M., Chiovato L., Friedlander J.A. et al. Serum antibodies against megalin (GP330) in patients with autoimmune thyroiditis // J. Clin. Endocrinol. Metab. 1999. V. 84. P. 2468–2474.

22. Marino M., Zheng G., Chiovato L. et al. Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells: a novel function in the control of thyroid hormone release // J. Biol. Chem. 2000. V. 275. P. 7125–7138.

23. Mariotti S., Caturegli P., Piccolo P. et al. Antythyroid peroxidase antibodies in thyroid diseases // J. Clin. Edocrinol. Metab. 1990. V. 71. P. 661–669.

24. Mascanfroni I., Montesinos M., Susperreguy S., Cervi et al. Control of dendritic cell maturation and function by triiodothyronine // FASEB J. 2008. V. 22. P. 1032–1042.

25. McLachlan S.M., Rapoport B. The molecular biology of thyroid peroxidase: Cloning, expression, and role as autoantigen in autoimmune thyroid dis-ease // Endocr. Rev. 1992. V. 13. P. 192–206.

26. Nakahara M., Nagayama Y., Saitoh O. et al. Expression of Immunoregulatory Molecules by Thyrocytes Protects Nonobese Diabetic-H2h4 Mice from Developing Autoimmune Thyroiditis // Endocrinol. 2009. V. 150. P. 1545–1551.

27. Neves S.R., Ram P.T., Iyengar R. G-protein pathways // Science. 2002. V. 296. P. 1636–1639.

28. Paolieri F., Salmaso C. Possible pathogenetic relevance of interleukin-1 beta in “destructive” organ-specific autoimmune disease (Hashimoto's thyroiditis) // Ann. N.Y. Acad. Sci. 1999. V. 22. N876. P. 221–228.

29. Phenekos C. Th1 and Th2 serum cytokine profiles characterize patients with Hashimotos thyroiditis (Th1) and Graves disease (Th2) // Neuroimmunomodul. 2004. V. 11. P. 209–213.

30. Poncin S., Lengele B., Colin I.M. et al. Differential Interactions between Th1/Th2, Th1/Th3, and Th2/Th3 Cytokines in the Regulation of Thyroperoxidase and Dual Oxidase Expression, and of Thyroglobulin Secretion in Thyrocytes in Vitro // Endocrinol. 2008. V. 149. P. 1534–1542.

31. Solerte S.B. Defect of a subpopulation of natural killer immune cells in Graves disease and Hashimotos thyroiditis: normalizing effect of dehydroepi-androsterone sulfate // Eur. J. Endocrinol. 2005. V. 152. P. 703–712.

32. Spitzweg C., Heufelder A.E. Update on the thyroid sodium iodide symporter: a novel thyroid antigen emerging on the horizon // Eur. J. Endocrinol. 1997. V. 137. P. 22–23.

33. Tang H., Meroni P.L. The effects of a monoclonal antibody to interferon-gamma on experimental autoimmune thyroiditis (EAT): prevention of disease and decrease of EAT-specific T cells // Eur. J. Immunol. 1993. V. 23. P. 275–278.

34. Vassart G., Dumont J.E. The thyrotropin receptor and the regulation of thyroid function and growth // Endocr. Rev. 1992. V. 13. P. 596–611.

35. Volpe R. The pathology of thyroiditis // Hum. Pathol. 1978. V. 9. P. 429–438.

36. Weetman A.P., Ajjan R.A. Cytokines and autoimmune thyroid diease // HOT THYROIDOLOGY (www.hotthyroidology.com). 2002. N1.

37. Wendling U. Expression of TRAIL receptors in human autoreactive and foreign antigen-specific T cells // Cell. Death. Differentiat. 2000. V. 7. P. 637–644.

38. Yanagisawa J., Takahashi M., Kanki H. et al. The molecular interaction of Fas and FAP-1: a tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis // J. Biol. Chem. 1997. V. 272. P. 8539–8545.

39. Zamai L. Natural killer (NK) cell-mediated cytotoxicity: differential use of TRAIL and Fas ligand by immature and mature primary human NK cells // J. Exper. Med. 1998. V. 188. P. 2375–2380.