Reproductive Function in Women with Graves’ Disease
https://doi.org/10.14341/ket20095251-57
Abstract
Reproductive function was evaluated in 308 with Graves’ disease (GD): in 250 retrospectively (group 1) and in 58 – prospectively (group 2); the control group included 34 healthy women in reproductive age. The manifestation of Graves’ disease was associated with menstrual abnormalities in 118 women (47.2%) in group 1 and in 37 women (63.8%) in group 2; the most common abnormalities were oligomenorrhea (26 and 21%) and hypomenorrhea (22 and 32%); premature and early menopause were found in 18 and 19%; polymenorrhea in 16% and 11% cases; hypermenorrhea in 11% and 6% cases; amenorrhea in 7% and 11% cases. The prevalence of spontaneous abortion in undertreated hyperthyroidism was 67%, but only 11.8% in case of stable disease (euthyroidism). GD was associated with lower ovarian reserve (high FSH, low Inhibin-B, Antimullerian hormone and ovarian volume). The most favorable results in the view of reproductive outcomes were achieved after radioiodine treatment of GD.
About the Authors
T KashirovaV Fadeyev
S Perminova
T Nazarenko
I Korneyeva
S Lesnikova
M Ibragimova
References
1. Абрамова Н.А., Фадеев В.В. Консервативное лечение болезни Грейвса: принципы, маркеры рецидива и ремиссии // Пробл. эндокринол. 2005. № 6. С. 44–49.
2. Дедов И.И., Мельниченко Г.А., Фадеев В.В. Эндокринология. М.: ГЭОТАР0МЕД, 2007.
3. Корнеева И.Е. Современная концепция диагностики и лечения бесплодия в браке: Дисс. … докт. мед. наук. М., 2003. 238 с.
4. Мельниченко Г.А., Фадеев В.В., Дедов И.И. Заболевания щитовидной железы во время беременности: Диагностика, лечение, профилактика / Пособие для врачей. М.: Мед-Эксперт-Пресс, 2003.
5. Перминова С.Г. Нарушения репродуктивной функции у женщин с патологией щитовидной железы Бесплодный брак. Современные подходы к диагностике и лечению / Под ред. В.И. Кулакова. М., 2005. С. 231–246.
6. Селезнева И.Ю. Бесплодный брак (эпидемиологическое исследование): Автореф. дисс. … канд. мед. наук. М., 1999.
7. Татарчук Т.Ф., Олейник В.А., Мамонова Т.О. Репродуктивная система женщин и нарушения функции щитовидной железы // Вест. ассоц. акуш.-гинекол. Украины. 2000. № 4. С. 16–23.
8. Фадеев В.В. Йододефицитные и аутоиммунные заболевания щитовидной железы в регионе легкого йодного дефицита: Автореф. дисс. … докт. мед. наук. М., 2004.
9. Alfadda A., Malubu U. H., El7Desouki M. I. et al. Treatment of Graves hyperthyroidism – prognostic factors for outcome // Saudi Med. J. 2007. V. 28. № 2. P. 225–230.
10. Benson R.C., Dailey M.E. The menstrual pattern in hyperthyroidism and subsequent posttherapy hypothyroidism // Surg. Gynecol. Obstet. 1955. V. 100. P. 19–26.
11. Goldsmith R.E., Sturgis S.H., Lerman J., Stanbury J.B. The menstrual pattern in thyroid disease // J. Clin. Endocrinol. Metab. 1952. V. 12. P. 846–855.
12. Joshi J.V., Bhandarkar S.D., Chadha M. et al. Menstrual irregularities and lactation failure may precede thyroid dysfunction or goitre // J. Postgrad. Med. V. 39. Р.137–141.
13. Krassas G.E. Thyroid disease and female reproduction G.F. Krassas // Fert. Steril. 2000. V. 74. P. 1063–1070.
14. Mezosi E. Hyperthyroidism // Orv. Hetil. 2006. V. 147. N 28. Р. 1309–1314.
15. Poppe K., Velkeniers B. Female infertility and the thyroid // Best. Pract. Res. Clin. Endocrinol. Metab. 2004. V. 18. P. 153–165.
16. Pradeep P.V., Agarwal A., Baxi et al. Safety and efficacy of surgical management of hyperthyroidism 15-year experience from a Tertiary Care Center in developing country // World J. Surg. 2007. V. 31. Р. 306–312.
17. Prummel M.F., Wiersinga W.M. Thyroid autoimmunity and miscarriage // Eur. J. Endocrinol. 2004. V. 150. Р. 751–755.
18. Redmond G.P. Thyroid dysfunction and women reproductive health // Thyroid. 2004. V. 14 (Suppl. 1) P. 5–15.
19. Tanaka T., Tamai H., Kuma K. et al. Gonadotropin response to luteinizing hormone releasing hormone in hyperthyroid patients with menstrual disturbances // Metabolism. 1981. V. 30. P. 323–326.
20. Weetman A. P. Grave`s disease (183502002) // Horm. Res. 2003. V. 59. P. 114–118.
21. Wille T., Muller B., Noth D. et al. Long0term follow-up after antithyroid drug treatment in Grave`s disease // Rundsch. Med. Prax. 2006. V. 95. P. 1121–1127.
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