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Prevalence of hypothyroidism among children and adolescents with diabetes mellitus by results of selective screening

https://doi.org/10.14341/ket20139142-45

Abstract

Establish the prevalence of hypothyroidism among children with diabetes mellitus (DM) as a result of selective screening. During the examination period 132 children (64 f/68 m) aged from 1.0 to 17.5 years were examined. Ultrasonography evaluation, including measurement of thyroid volume, was performed in all volunteers as well as analysis of TSH, TPOAb and fT4 when TSH was out of reference range. The prevalence of overt hypothyroidism (7,6%) in the outcome of AIT in children with DM was above the population level, which confirms the effective of selective screening in this group of children and demands to its introduction into routine clinical practice; high incidence of TPOAb (12.8%) need to clarify their prognostic value having regard to longterm followup, as well as revising of dividing cutofpoint.

About the Authors

K Alexandrov

aspirant kafedry pediatrii FPK i PP GBOU VPO “UGMA” MZ RF


A Kiyaev

doktor med. nauk, dotsent kafedry pediatrii FPK i PP GBOU VPO “UGMA” MZ RF, nachal'nik otdela endokrinologii GBUZ SO “ODKB № 1”, glavnyy detskiy endokrinolog MZ Sverdlovskoy oblasti


O Kovtun

doktor med. nauk, professor, zaveduyushchaya kafedroy pediatrii FPK i PP GBOU VPO “UGMA” MZ RF, prorektor UGMA po nauchnoy rabote


S Belyaeva

kand. med. nauk, zaveduyushchaya biokhimicheskoy laboratoriey MU “KDTs”


References

1. Дедов И.И., Шестакова М.В. Сахарный диабет. Руководство для врачей. М.: Универсум Паблишинг, 2003. 456 с.

2. Kordonouri O., Klinghammer A., Lang E.B. et al. Thyroid autoim munity in children and adolescents with type 1 diabetes: a multi center survey. Diabetes Care. 2002; 24: 1346–1350.

3. De Block C.E., De Leeuw I.H., Vertommen J.J. et al. Betacell, thy roid, gastric, adrenal and coeliac autoimmunity and HLADQ types in type 1 diabetes. Clin. Exp. Immunol. 2001; 126: 236–241.

4. Van den Driessche A., Eenkhoorn V., Van Gaal L. et al. Type 1 dia betes and autoimmune polyglandular syndrome: a clinical review. J. Med. 2009; 67: 376–387.

5. Kota S.K., Meher L.K., Jammula S. et al. Clinical profile of coex isting conditions in type 1 diabetes mellitus patients. Diabetes Metab. Syndr. 2012; 6: 70–76.

6. Kabelitz M., Liesenkotter K.P., Stach B. et al. The prevalence of antithyroid peroxidase antibodies and autoimmune thyroiditis in children and adolescents in an iodine replete area. Eur. J. Endocrinol. 2003; 148 (3): 301–307.

7. Loviselli A., Velluzzi F., Mossa P. et al. The Sardinian Auto immunity Study: 3. Studies on circulating antithyroid antibodies in Sardinian schoolchildren: relationship to goiter prevalence and thyroid function. J. Thyroid. 2001; 11 (9): 849–857.

8. Gopalakrishnan S., Singh S.P., Prasad W.R. et al. Prevalence of goitre and autoimmune thyroiditis in schoolchildren in Delhi, India, after two decades of salt iodisation. J. Pediatr. Endocrinol. Metab. 2006; 19 (7): 889–893.

9. Marhawa R.K., Tandon N., Karak A.K. et al. Hahimoto’s thyroidi tis countrywide screening of goitrous healthy girls in postiodization phase in India. J. Clin. Endocrinol. Metab. 2000; 85: 3798–3802.

10. Zois C., Stavrou I., Kalogera C. et al. High prevalence of autoim mune thyroiditis in schoolchildren after elimination of iodine defi ciency in northwestern Greece. J. Thyroid. 2003; 13 (5): 485–489.

11. Jaruratanasirikul S., Leethanaporn K., Khuntigij P. et al. The clini cal course of Hashimoto's thryoiditis in children and adolescents: 6 years longitudinal followup. J. Pediatr. Endocrinol. Metab. 2001; 14 (2): 177–184.

12. Radetti G., Gottardi E., Bona G. et al. The natural history of euthy roid Hashimoto's thyroiditis in children. J. Pediatr. 2006; 149 (6): 827–832.

13. Dittmar M., Kahaly G.J. Polyglandular autoimmune syndromes: immunogenetics and longterm followup. J. Clin. Endocrinol. Metab. 2003; 88 (7): 2983–2992.

14. Levin L., Tomer Y. The etiology of autoimmune diabetes and thy roiditis: evidence for common genetic susceptibility. Autoimmun. Rev. 2003; 6 (2): 377–386.

15. Kordonouri O., Deiss D., Danne T. et al. Predictivity of thyroid autoantibodies for the development of thyroid disorders in children and adolescents with Type 1 diabetes. Diabet. Med. 2002; 19 (6): 518–521.

16. Valerio G., Maiuri L., Troncone R. et al. Severe clinical onset of dia betes and increased prevalence of other autoimmune diseases in children with coeliac disease diagnosed before diabetes mellitus. J. Diabetologia. 2002; 45 (12): 1719–1722.

17. FrohlichReiterer E.E., Hofer S., Kaspers S. et al. Screening fre quency for celiac disease and autoimmune thyroiditis in children and adolescents with type 1 diabetes mellitus – data from a German/Austrian multicentre survey. Pediatr. Diabetes. 2008; 9 (6): 546–553.

18. ISPAD Consensus guidelines for the management of type 1 dia betes mellitus in children and adolescents / ISPAD 2000 Consensus Guidelines.

19. Severinski S., Banac S., Severinski N.S. et al. Epidemiology and clinical characteristics of thyroid dysfunction in children and ado lescents with type 1 diabetes. Coll. Antropol. 2009; 33 (1): 273–279.

20. Umpierrez G.E., Latif K.A., Murphy M.B. Thyroid dysfunction in patients with type 1 diabetes: a longitudinal study. Diabetes Care. 2003; 26 (4): 1181–1185.

21. Hansen D., Bennedbaek F.N., HoierMadsen M. A prospective study of thyroid function, morphology and autoimmunity in young patients with type 1 diabetes. Eur. J. Endocrinol. 2003; 148 (2): 245–251.

22. Silverstein J., Klingensmith G., Copeland K. et al. Care of children and adolescents with type 1 diabetes: a statement of the American Diabetes Association. J. Diabetes Care. 2005; 28 (1): 186–212.

23. Prazny M., Skrha J., Limanova Z. et al. Screening for associated autoimmunity in type 1 diabetes mellitus with respect to diabetes control. J. Physiol Res. 2005; 54 (1): 41–48.

24. Abdulmoein AlAgha, Ali Ocheltree, Amr Hakeem. Thyroid dysfunc tion in children and adolescents with type 1 diabetes mellitus. J. of Pediatric Sciences. 2011; 93 (3): 1–5.

25. Mohn A., Di Michele S., Di Luzio R. et al. The effect of subclinical hypothyroidism on metabolic control in children and adolescents with Type 1 diabetes mellitus. Diabet. Med. 2002; 19 (1): 70–73.

26. ISPAD Consensus guidelines for the management of type 1 dia betes mellitus in children and adolescents / ISPAD 2011 Consensus Guidelines.

27. Дедов И.И., Петеркова В.А., Кураева Т.Л. Российский консенсус по терапии сахарного диабета у детей и подростков. Сахарный диабет. 2010; (спецвыпуск): 1–8.


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For citations:


 ,  ,  ,   Prevalence of hypothyroidism among children and adolescents with diabetes mellitus by results of selective screening. Clinical and experimental thyroidology. 2013;9(1):42-45. (In Russ.) https://doi.org/10.14341/ket20139142-45

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