Association between CD40 C/T1 polymorphism and familial autoimmune thyroid disease
https://doi.org/10.14341/ket20139345-50
Abstract
High prevalence of family cases of autoimmune thyroid diseases (AITD) causes requirement of researching this group of patients. The objective of this study is to estimate genotypes and alleles frequencies of CD40 C(1)T poly morphism (rs1883832) in Graves` disease and Hashimoto`s disease families at least two firstdegree affected relatives. 70 patients with AITD took part in the study (35 families) and 76 control subjects. Results suggested that carrying of CT and TT genotypes of CD40 C(1)T polymorphism is associated with the low risk of developing of Graves` disease family cases without any regards to degree relationship. No association between CD40 C(1)T polymorphism and Hashimoto`s disease was identified. Carrying of allele C is associated with the high risk of developing of Graves` dis ease family cases odds ratio OR = 2,669, 95% CI, 1,6124,39, but not Hashimoto`s disease family cases.
About the Authors
A Pyankovazaochnyy aspirant FGBU “NII terapii i profilakticheskoy meditsiny” SO RAMN
V Maksimov
doktor med. nauk, zaveduyushchiy laboratoriey molekulyarnogeneticheskikh issledovaniy tera pevticheskikh zabolevaniy FGBU “NII terapii i profilakticheskoy meditsiny” SO RAMN
O Rymar
doktor med. nauk, vedushchiy nauchnyy sotrudnik laboratorii klinikopopulyatsionnykh i profilakticheskikh issledovaniy terapevticheskikh i endokrinnykh zabolevaniy FGBU “NII terapii i profilakticheskoy medi tsiny” SO RAMN
S Mustafina
kandidat med. nauk, starshiy nauchnyy sotrudnik laboratorii kliniko populyatsionnykh i profilakticheskikh issledovaniy terapevticheskikh i endokrinnykh zabolevaniy FGBU “NII terapii i profilakticheskoy meditsiny” SO RAMN
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, , , Association between CD40 C/T1 polymorphism and familial autoimmune thyroid disease. Clinical and experimental thyroidology. 2013;9(3):45-50. (In Russ.) https://doi.org/10.14341/ket20139345-50
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