The Relationship between TSH Values and Cardiovascular Risk Factors in Patients with Autoimmune Thyroiditis and Subclinical Hypothyroidism
https://doi.org/10.14341/CET201410216-21
Abstract
The study aimed to investigate the relationship between TSH values and the presence of cardiovascular and some metabolic disorders in 186 patients with autoimmune thyroiditis without hyper" and overt hypothyroidism. Results. In the ROC analysis, a level of TSH ≥ 4.47 mu/L was found to predict diastolic dysfunction of the right and / or left ventricles with 70.8 [48.9; 87.3] % sensitivity and 69.1 [55.2; 80.8] % specificity (AUC: 0.678 [0.563; 0.778], p = 0.036). The level of TSH ≥ 5.25 mu/L predicted the presence of anemia with 54.8 [39.7; 70.1] % sensitivity and 54,8 [44.2; 65.2] % specificity (AUC: 0.603 [0.516; 0.688], p = 0.068) as well as some other cardiovascular and meta" bolic abnormalities. Conclusion. Among the patients with subclinical hypothyroidism (SCH), the level of TSH over 5.25 mu/L might be considered a predictive marker for increased risk of SCH associated disorders.
About the Authors
T NekrasovaNizhny Novgorod State Medical Academy
L Strongin
Nizhny Novgorod State Medical Academy
O Ledentsova
Nizhny Novgorod Regional Diagnostic Center
L Kasakova
Volga Region Medical Center
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Review
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, , , The Relationship between TSH Values and Cardiovascular Risk Factors in Patients with Autoimmune Thyroiditis and Subclinical Hypothyroidism. Clinical and experimental thyroidology. 2014;10(2):16-21. (In Russ.) https://doi.org/10.14341/CET201410216-21
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