Thyroid disorders in acute period after radiation therapy on neck region
https://doi.org/10.14341/ket2015251-54
Abstract
Aim. The aim of our study was to analyze thyroid status in adult patients with Hodgkin’s lymphoma in acute period after radiotherapy on neck region. Material and methods. Thyroid function (TSH, free T 4, anti-TPO) and thyroid ultrasound were evaluated in 22 adults (10 women, 12 men, mean age 30.2 yrs) with a history of Hodgkin’s lymphoma (HL) before radiotherapy on neck region, 7-14 days, 6 month, 1 year after treatment. Results. Incidence of subclinical hyperthyroidism was 13.6% in acute period (7-14 days) after radiotherapy on neck region. There was correlation between dose of radiation and incidence of acute thyroiditis ( r = 0.67, p = 0.03). TSH level fall directly after treatment (1.08 vs 1.88 mkMEd/l р = 0.03), but 6 month after this difference disappeared. T 4 free level decreased 1 yr after treatment (1.18 vs 0.99 ng/ml ) in compare with measurement before treatment ( p = 0,01). Thyroid volume decreased (9.8 ml vs 5.7 ml) 6 month after radiotherapy in compare with measurement before treatment ( p = 0.03), and keep on decreasing 1 yr after treatment (5.35 vs 9.7 ml p = 0.003). Conclusions. These data indicate that some patients with HL receiving high dose of radiotherapy on neck region can develop acute thyroiditis, but this abnormalities are transitory and do not reviewed treatment.
About the Authors
E I Bobrova
Sechenov First Moscow State Medical University, Moscow, Russian Federation
V V Fadeev
Sechenov First Moscow State Medical University, Moscow, Russian Federation
V M Sotnikov
Russian Scientific Center of Roentgeno-Radiology, Moscow, Russian Federation
M G Pavlova
Sechenov First Moscow State Medical University, Moscow, Russian Federation
Yu P Sych
Sechenov First Moscow State Medical University, Moscow, Russian Federation
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Review
For citations:
Bobrova E.I., Fadeev V.V., Sotnikov V.M., Pavlova M.G., Sych Yu.P. Thyroid disorders in acute period after radiation therapy on neck region. Clinical and experimental thyroidology. 2015;11(2):51-54. (In Russ.) https://doi.org/10.14341/ket2015251-54
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