Levothyroxine steadily maintains its position as the «gold standard» in the treatment of hypothyroidism. Despite the possibility of step-by-step tableted dose titration of levothyroxine, the results of many studies reliably point to the fact that a significant number of patients do not reach the target level of thyroid hormone. One of the main reasons for the therapy ineffectiveness is the inconvenience of levothyroxine sodium regimen for many patients, associated with the need to observe certain time intervals before meals and other medications. The above-mentioned factors have stimulated a number of studies aimed at developing new dosage forms with significant advantages in the pharmacokinetics and pharmacodynamics of drugs. The review provides the latest data on the new dosage forms of levothyroxine. Further large-scale clinical trials are needed for a more reasonable and widespread use of new dosage forms of levothyroxine in clinical practice.

Given the widespread iodine deficiency, diffuse and diffuse nodular euthyroid goiter is an urgent problem. A large goiter needs to be highlighted both from the perspective of possible complications for the patient, including a decrease in the quality of life and compression syndrome, as well as from the perspective of the complexity of surgical treatment, given the technical complexity of the operation and the high probability of intraoperative and postoperative complications. The article describes a clinical case of a patient admitted to the endocrinology department with a diagnosis of diffuse nodular goiter of the 2nd degree for examination with complaints of a huge deforming formation of the neck contours, difficulty breathing when walking and during sleep. It is known from the anamnesis that the patient has been observed for about 10 years by an endocrinologist with nodular goiter. The patient was repeatedly offered surgical treatment, which he categorically refused. In the Department of endocrinology, the patient underwent a comprehensive examination to assess the condition and function of the thyroid gland, as well as to identify possible complications.

Subacute thyroiditis is an inflammatory disease of the thyroid gland. Clinical manifestations include pain or discomfort in the neck, a painful diffuse goiter, and a transient episode of hyperthyroidism. We describe the case of a 48-year-old woman who had no symptoms characteristic of subacute thyroiditis. The test results were consistent with a clinical diagnosis of secondary hypothyroidism. The patient had a history of asymptomatic COVID-19 episode 6 months ago and neck pain one month ago. This case demonstrates the importance of a detailed history, comprehensive examination, and correct interpretation of laboratory and instrumental findings in making the diagnosis.

ENDO 2022 — the key international event dedicated to endocrine diseases — was held in June 2022. This article provides a brief overview of the event and is focused on the thyroid disease.